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228 Engineered human IL-2/IL-2Rß orthogonal pairs selectively enhance anti-GPC3 CAR T cells in vivo to drive complete responses in solid epithelial tumor models by Martin Oft, Mohammed Ali, Ryan Burgess, Michele Bauer, Deepti Rokkam, Navneet Ratti, Sandro Vivona, Patrick Lupardus, Paul-Joseph Aspuria, Marie Semana, Ivan Cheng, Mahalaksmi Ramadass, Henry Rosas, George Zheng
Published 2023-11-01Article -
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1053 Preclinical pharmacodynamic characterization of STK-026: a novel IL-12 partial agonist for cancer with maintained CD8 T cell activity, reduced NK-mediated toxicity and an impr... by Martin Oft, Michael Totagrande, Luis Zuniga, David B Rosen, Priyanka Balasubrahmanyam, Zhenya Koliesnik, Ryan Burgess, Kim Q Tran, Michele Bauer, Bharghavi Jayaraman, Cindy Buffone, Jan Emmerich, Deepti Chaturvedi, Deepti Rokkam, Rene De Waal Malefyt, Heiko Greb, Navneet Ratti, Sandro Vivona, Robert Kastelein, Patrick Lupardus
Published 2023-11-01Article