Diagnosis of Myelodysplastic Syndromes: From Immunological Observations to Clinical Applications by Yannick Simoni, Nicolas Chapuis

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From Iron Chelation to Overload as a Therapeutic Strategy to Induce Ferroptosis in Leukemic Cells by Eric Grignano, Eric Grignano, Rudy Birsen, Rudy Birsen, Nicolas Chapuis, Nicolas Chapuis, Didier Bouscary, Didier Bouscary

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Rationale for Targeting Deregulated Metabolic Pathways as a Therapeutic Strategy in Acute Myeloid Leukemia by Nicolas Chapuis, Nicolas Chapuis, Nicolas Chapuis, Nicolas Chapuis, Nicolas Chapuis, Laury Poulain, Laury Poulain, Laury Poulain, Laury Poulain, Rudy Birsen, Rudy Birsen, Rudy Birsen, Rudy Birsen, Jerome Tamburini, Jerome Tamburini, Jerome Tamburini, Jerome Tamburini, Jerome Tamburini, Didier Bouscary, Didier Bouscary, Didier Bouscary, Didier Bouscary, Didier Bouscary

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S169: MODULATION OF THE IMMUNE LANDSCAPE IN LOWER-RISK MYELODYSPLASTIC SYNDROMES WITH IMETELSTAT-INDUCED TRANSFUSION INDEPENDENCY by Nicolas Chapuis, David Rombaut, Yannick Simoni, Fei Huang, Michaela Fontenay

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Artificial intelligence to empower diagnosis of myelodysplastic syndromes by multiparametric flow cytometry by Valentin Clichet, Delphine Lebon, Nicolas Chapuis, Jaja Zhu, Valérie Bardet, Jean-Pierre Marolleau, Loïc Garçon, Alexis Caulier, Thomas Boyer

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Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia by Sophie Park, Nicolas Chapuis, Jérôme Tamburini, Valérie Bardet, Pascale Cornillet-Lefebvre, Lise Willems, Alexa Green, Patrick Mayeux, Catherine Lacombe, Didier Bouscary

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T-cell large granular lymphocyte leukemia transfomation into aggressive T-cell lymphoma: a report of two cases with molecular characterization by Maya Belhadj, Dalila Mansour, Sophie Kaltenbach, Benedicte Deau-Fischer, Patricia Franchi, Jérôme Tamburini, Nicolas Chapuis, Diane Damotte, Olivier Kosmider, Barbara Burroni, Didier Bouscary

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Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody by Nicolas Chapuis, Jérôme Tamburini, Pascale Cornillet-Lefebvre, Lucile Gillot, Valérie Bardet, Lise Willems, Sophie Park, Alexa S Green, Norbert Ifrah, François Dreyfus, Patrick Mayeux, Catherine Lacombe, Didier Bouscary

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Enhanced fetal hematopoiesis in response to symptomatic SARS-CoV-2 infection during pregnancy by Mansour Alkobtawi, Qui Trung Ngô, Nicolas Chapuis, Romain H. Fontaine, Mira El Khoury, Matthieu Tihy, Nawa Hachem, Aude Jary, Vincent Calvez, Michaela Fontenay, Vassilis Tsatsaris, Sélim Aractingi, Bénédicte Oulès

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Diagnosis of acute promyelocytic leukemia based on routine biological parameters using machine learning by Estelle Cheli, Simon Chevalier, Olivier Kosmider, Marion Eveillard, Nicolas Chapuis, Adriana Plesa, Maël Heiblig, Lydie Andre, Jenny Pouget, Pascal Mossuz, Olivier Theisen, Vincent Alcazer, Dan Gugenheim, Nicolas Autexier, Pierre Sujobert

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APR-246 induces early cell death by ferroptosis in acute myeloid leukemia by Rudy Birsen, Clement Larrue, Justine Decroocq, Natacha Johnson, Nathan Guiraud, Mathilde Gotanegre, Lilia Cantero-Aguilar, Eric Grignano, Tony Huynh, Michaela Fontenay, Olivier Kosmider, Patrick Mayeux, Nicolas Chapuis, Jean Emmanuel Sarry, Jerome Tamburini, Didier Bouscary

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Subcutaneous azacitidine maintenance in transplantineligible patients with acute myeloid leukemia: a single-center retrospective study by Natacha Johnson, Marie Templé, Chloe Friedrich, Lise Willems, Rudy Birsen, Marguerite Vignon, Paul Deschamps, Patricia Franchi, Johanna Mondesir, Benedicte Deau-Fischer, Elsa Miekoutima, Ismaël Boussaid, Nicolas Chapuis, Olivier Kosmider, Didier Bouscary, Jerome Tamburini, Justine Decroocq

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Multicentric study underlining the interest of adding CD5, CD7 and CD56 expression assessment to the flow cytometric Ogata score in myelodysplastic syndromes and myelodysplastic/my... by Valérie Bardet, Orianne Wagner-Ballon, Julien Guy, Céline Morvan, Camille Debord, Franck Trimoreau, Emmanuel Benayoun, Nicolas Chapuis, Nicolas Freynet, Cédric Rossi, Stéphanie Mathis, Marie-Pierre Gourin, Andréa Toma, Marie C. Béné, Jean Feuillard, Estelle Guérin

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Flow cytometric analysis of erythroid precursors and mutational signatures of lower risk myelodysplastic syndromes identify responders to erythroid stimulating agents by Marco G. Raddi, Sara Bencini, Benedetta Peruzzi, Giorgio Mattiuz, Sven De Pourcq, Michele Tanturli, Nicolas Chapuis, Angela Consagra, Luca Rigodanza, Cristina Amato, Alessandro Sanna, Elena Tofacchi, Enrico Attardi, Sophie Park, Olivier Kosmider, Francesco Annunziato, Michaela Fontenay, Valeria Santini

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High levels of CD34+CD38low/−CD123+ blasts are predictive of an adverse outcome in acute myeloid leukemia: a Groupe Ouest-Est des Leucémies Aiguës et Maladies du Sang (GOELAMS) stu... by François Vergez, Alexa S. Green, Jerome Tamburini, Jean-Emmanuel Sarry, Baptiste Gaillard, Pascale Cornillet-Lefebvre, Melanie Pannetier, Aymeric Neyret, Nicolas Chapuis, Norbert Ifrah, François Dreyfus, Stéphane Manenti, Cecile Demur, Eric Delabesse, Catherine Lacombe, Patrick Mayeux, Didier Bouscary, Christian Recher, Valerie Bardet

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A miR-150/TET3 pathway regulates the generation of mouse and human non-classical monocyte subset by Dorothée Selimoglu-Buet, Julie Rivière, Hussein Ghamlouch, Laura Bencheikh, Catherine Lacout, Margot Morabito, M’boyba Diop, Guillaume Meurice, Marie Breckler, Aurélie Chauveau, Camille Debord, Franck Debeurme, Raphael Itzykson, Nicolas Chapuis, Christophe Willekens, Orianne Wagner-Ballon, Olivier A. Bernard, Nathalie Droin, Eric Solary

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ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data by James W Opzoomer, Jessica A Timms, Kevin Blighe, Thanos P Mourikis, Nicolas Chapuis, Richard Bekoe, Sedigeh Kareemaghay, Paola Nocerino, Benedetta Apollonio, Alan G Ramsay, Mahvash Tavassoli, Claire Harrison, Francesca Ciccarelli, Peter Parker, Michaela Fontenay, Paul R Barber, James N Arnold, Shahram Kordasti

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Venetoclax combination therapy induces deep AML remission with eradication of leukemic stem cells and remodeling of clonal haematopoiesis by Romain Vazquez, Claire Breal, Loria Zalmai, Chloe Friedrich, Carole Almire, Adrien Contejean, Sylvain Barreau, Eric Grignano, Lise Willems, Benedicte Deau-Fischer, Patricia Franchi, Marguerite Vignon, Justine Decroocq, Rudy Birsen, Lauriane Goldwirt, Sophie Kaltenbach, Lucile Couronne, Michaela Fontenay, Olivier Kosmider, Didier Bouscary, Nicolas Chapuis

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S162: LOSS OF HEMATOPOIETIC PROGENITORS HETEROGENEITY IS AN ADVERSE PROGNOSTIC FACTOR IN MYELODYSPLASTIC SYNDROMES by Charles Dussiau, Thibault Comont, Camille Knosp, Ines Vergnolle, Clotilde Bravetti, Alban Canali, Amandine Houvert, Laetitia Largeaud, Christian Daveaux, Laila Zaroili, Chloe Friedrich, Ismael Boussaid, Loria Zalmai, Carole Almire, Odile Beyne-Rauzy, Lise Willems, Didier Bouscary, Olivier Gandrillon, Michaela Fontenay, Oliver Kosmider, Francois Vergez, Nicolas Chapuis

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Optical genome mapping refines cytogenetic diagnostics, prognostic stratification and provides new molecular insights in adult MDS/AML patients by Estelle Balducci, Sophie Kaltenbach, Patrick Villarese, Eugénie Duroyon, Loria Zalmai, Chloé Friedrich, Felipe Suarez, Ambroise Marcais, Didier Bouscary, Justine Decroocq, Rudy Birsen, Michaëla Fontenay, Marie Templé, Chantal Brouzes, Aurore Touzart, Thomas Steimlé, Agata Cieslak, Ludovic Lhermitte, Carole Almire, Nicolas Chapuis, Olivier Hermine, Vahid Asnafi, Olivier Kosmider, Lucile Couronné

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