The impact of rare and low-frequency genetic variants in common disease 由 Lorenzo Bomba, Klaudia Walter, Nicole Soranzo

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Personalized and graph genomes reveal missing signal in epigenomic data 由 Cristian Groza, Tony Kwan, Nicole Soranzo, Tomi Pastinen, Guillaume Bourque

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Ancient and recent positive selection transformed opioid cis-regulation in humans. 由 Matthew V Rockman, Matthew W Hahn, Nicole Soranzo, Fritz Zimprich, David B Goldstein, Gregory A Wray

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A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. 由 Ewa Bielczyk-Maczyńska, Jovana Serbanovic-Canic, Lauren Ferreira, Nicole Soranzo, Derek L Stemple, Willem H Ouwehand, Ana Cvejic

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Genetic Influences on Metabolite Levels: A Comparison across Metabolomic Platforms. 由 Idil Yet, Cristina Menni, So-Youn Shin, Massimo Mangino, Nicole Soranzo, Jerzy Adamski, Karsten Suhre, Tim D Spector, Gabi Kastenmüller, Jordana T Bell

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No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants 由 Na Cai, Na Cai, Monika Fňašková, Monika Fňašková, Klára Konečná, Klára Konečná, Miloslava Fojtová, Miloslava Fojtová, Jiří Fajkus, Jiří Fajkus, Eve Coomber, Stephen Watt, Nicole Soranzo, Marek Preiss, Ivan Rektor

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Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis 由 Lucy J. Goudswaard, Laura J. Corbin, Kate L. Burley, Andrew Mumford, Parsa Akbari, Nicole Soranzo, Adam S. Butterworth, Nicholas A. Watkins, Dimitri J. Pournaras, Jessica Harris, Nicholas J. Timpson, Ingeborg Hers

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Machine learning optimized polygenic scores for blood cell traits identify sex-specific trajectories and genetic correlations with disease 由 Yu Xu, Dragana Vuckovic, Scott C. Ritchie, Parsa Akbari, Tao Jiang, Jason Grealey, Adam S. Butterworth, Willem H. Ouwehand, David J. Roberts, Emanuele Di Angelantonio, John Danesh, Nicole Soranzo, Michael Inouye

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A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. 由 Fumihiko Takeuchi, Ralph McGinnis, Stephane Bourgeois, Chris Barnes, Niclas Eriksson, Nicole Soranzo, Pamela Whittaker, Venkatesh Ranganath, Vasudev Kumanduri, William McLaren, Lennart Holm, Jonatan Lindh, Anders Rane, Mia Wadelius, Panos Deloukas

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Correction: Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits. 由 Dirk S. Paul, James P. Nisbet, Tsun-Po Yang, Stuart Meacham, Augusto Rendon, Katta Hautaviita, Jonna Tallila, Jacqui White, Marloes R. Tijssen, Suthesh Sivapalaratnam, Hanneke Basart, Mieke D. Trip, Berthold Göttgens, Nicole Soranzo, Willem H. Ouwehand, Panos Deloukas

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The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue. 由 Alexander W Drong, George Nicholson, Asa K Hedman, Eshwar Meduri, Elin Grundberg, Kerrin S Small, So-Youn Shin, Jordana T Bell, Fredrik Karpe, Nicole Soranzo, Tim D Spector, Mark I McCarthy, Panos Deloukas, Mattias Rantalainen, Cecilia M Lindgren, MolPAGE Consortia

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Immune disease variants modulate gene expression in regulatory CD4+ T cells 由 Lara Bossini-Castillo, Dafni A. Glinos, Natalia Kunowska, Gosia Golda, Abigail A. Lamikanra, Michaela Spitzer, Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, Claire Cattermole, Kaur Alasoo, Alice Mann, Kousik Kundu, Anna Lorenc, Nicole Soranzo, Ian Dunham, David J. Roberts, Gosia Trynka

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Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits. 由 Dirk S Paul, James P Nisbet, Tsun-Po Yang, Stuart Meacham, Augusto Rendon, Katta Hautaviita, Jonna Tallila, Jacqui White, Marloes R Tijssen, Suthesh Sivapalaratnam, Hanneke Basart, Mieke D Trip, Cardiogenics Consortium, MuTHER Consortium, Berthold Göttgens, Nicole Soranzo, Willem H Ouwehand, Panos Deloukas

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FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression 由 Kia Joo Puan, Boris San Luis, Nurhashikin Yusof, Dilip Kumar, Anand Kumar Andiappan, Wendy Lee, Samanta Cajic, Dragana Vuckovic, Jing De Chan, Tobias Döllner, Han Wei Hou, Yunxuan Jiang, Chao Tian, the 23andMe Research Team, Erdmann Rapp, Michael Poidinger, De Yun Wang, Nicole Soranzo, Bernett Lee, Olaf Rötzschke

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The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits. 由 Josine L Min, Jennifer M Taylor, J Brent Richards, Tim Watts, Fredrik H Pettersson, John Broxholme, Kourosh R Ahmadi, Gabriela L Surdulescu, Ernesto Lowy, Christian Gieger, Chris Newton-Cheh, Markus Perola, Nicole Soranzo, Ida Surakka, Cecilia M Lindgren, Jiannis Ragoussis, Andrew P Morris, Lon R Cardon, Tim D Spector, Krina T Zondervan

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Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming 由 Thomas Moreau, Amanda L. Evans, Louella Vasquez, Marloes R. Tijssen, Ying Yan, Matthew W. Trotter, Daniel Howard, Maria Colzani, Meera Arumugam, Wing Han Wu, Amanda Dalby, Riina Lampela, Guenaelle Bouet, Catherine M. Hobbs, Dean C. Pask, Holly Payne, Tatyana Ponomaryov, Alexander Brill, Nicole Soranzo, Willem H. Ouwehand, Roger A. Pedersen, Cedric Ghevaert

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Correction: Corrigendum: Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming 由 Thomas Moreau, Amanda L. Evans, Louella Vasquez, Marloes R. Tijssen, Ying Yan, Matthew W. Trotter, Daniel Howard, Maria Colzani, Meera Arumugam, Wing Han Wu, Amanda Dalby, Riina Lampela, Guenaelle Bouet, Catherine M. Hobbs, Dean C. Pask, Holly Payne, Tatyana Ponomaryov, Alexander Brill, Nicole Soranzo, Willem H. Ouwehand, Roger A. Pedersen, Cedric Ghevaert

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Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations 由 Yali Xue, Massimo Mezzavilla, Marc Haber, Shane McCarthy, Yuan Chen, Vagheesh Narasimhan, Arthur Gilly, Qasim Ayub, Vincenza Colonna, Lorraine Southam, Christopher Finan, Andrea Massaia, Himanshu Chheda, Priit Palta, Graham Ritchie, Jennifer Asimit, George Dedoussis, Paolo Gasparini, Aarno Palotie, Samuli Ripatti, Nicole Soranzo, Daniela Toniolo, James F. Wilson, Richard Durbin, Chris Tyler-Smith, Eleftheria Zeggini

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Correction: Identification of Gene for Hip Bone Size Variation in Females in a Genome-Wide Association Study. 由 Yao-Zhong Liu, Scott G. Wilson, Liang Wang, Xiao-Gang Liu, Yan-Fang Guo, Jian Li, Han Yan, Panos Deloukas, Nicole Soranzo, Usha Chinappen-Horsley, Alessandra Cervino, Frances M. Williams, Dong-Hai Xiong, Yin-Ping Zhang, Tian-Bo Jin, Shawn Levy, Christopher J. Papasian, Betty M. Drees, James J. Hamilton, Robert R. Recker, Tim D. Spector, Hong-Wen Deng

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Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study. 由 Yao-Zhong Liu, Scott G Wilson, Liang Wang, Xiao-Gang Liu, Yan-Fang Guo, Jian Li, Han Yan, Panos Deloukas, Nicole Soranzo, Usha Chinappen-Horsley, Alessandra Cervino, Frances M Williams, Dong-Hai Xiong, Yin-Ping Zhang, Tian-Bo Jin, Shawn Levy, Christopher J Papasian, Betty M Drees, James J Hamilton, Robert R Recker, Tim D Spector, Hong-Wen Deng

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