Nicole Soranzo

Nicole Soranzo is an Italian-British senior group leader in human genetics at the Wellcome Sanger Institute, Professor of Human Genetics at the University of Cambridge. She is an internationally recognised Human Geneticist who has focused on the application of cutting edge genomic technologies to study the spectrum of human genetic variation associated with cardio-metabolic and immune diseases. She has led many large-scale discovery efforts including more than 1,000 novel genetic variants associated with cardio-metabolic diseases and their risk factors as well as establishing the HaemGen consortium, which is a worldwide effort to discover genetic determinants of blood cell formation and also interpretation of the downstream consequences of sequence variation through a host of integrative analyses and functional approaches. Provided by Wikipedia
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  1. 1
    The impact of rare and low-frequency genetic variants in common disease

    The impact of rare and low-frequency genetic variants in common disease by Lorenzo Bomba, Klaudia Walter, Nicole Soranzo

    Published 2017-04-01
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  2. 2
    Personalized and graph genomes reveal missing signal in epigenomic data

    Personalized and graph genomes reveal missing signal in epigenomic data by Cristian Groza, Tony Kwan, Nicole Soranzo, Tomi Pastinen, Guillaume Bourque

    Published 2020-05-01
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  3. 3
    Ancient and recent positive selection transformed opioid cis-regulation in humans.

    Ancient and recent positive selection transformed opioid cis-regulation in humans. by Matthew V Rockman, Matthew W Hahn, Nicole Soranzo, Fritz Zimprich, David B Goldstein, Gregory A Wray

    Published 2005-12-01
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  4. 4
    A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis.

    A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. by Ewa Bielczyk-Maczyńska, Jovana Serbanovic-Canic, Lauren Ferreira, Nicole Soranzo, Derek L Stemple, Willem H Ouwehand, Ana Cvejic

    Published 2014-07-01
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  5. 5
    Genetic Influences on Metabolite Levels: A Comparison across Metabolomic Platforms.

    Genetic Influences on Metabolite Levels: A Comparison across Metabolomic Platforms. by Idil Yet, Cristina Menni, So-Youn Shin, Massimo Mangino, Nicole Soranzo, Jerzy Adamski, Karsten Suhre, Tim D Spector, Gabi Kastenmüller, Jordana T Bell

    Published 2016-01-01
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  6. 6
    No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants

    No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants by Na Cai, Na Cai, Monika Fňašková, Monika Fňašková, Klára Konečná, Klára Konečná, Miloslava Fojtová, Miloslava Fojtová, Jiří Fajkus, Jiří Fajkus, Eve Coomber, Stephen Watt, Nicole Soranzo, Marek Preiss, Ivan Rektor

    Published 2020-03-01
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  7. 7
    Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis

    Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis by Lucy J. Goudswaard, Laura J. Corbin, Kate L. Burley, Andrew Mumford, Parsa Akbari, Nicole Soranzo, Adam S. Butterworth, Nicholas A. Watkins, Dimitri J. Pournaras, Jessica Harris, Nicholas J. Timpson, Ingeborg Hers

    Published 2022-08-01
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  8. 8
    Machine learning optimized polygenic scores for blood cell traits identify sex-specific trajectories and genetic correlations with disease

    Machine learning optimized polygenic scores for blood cell traits identify sex-specific trajectories and genetic correlations with disease by Yu Xu, Dragana Vuckovic, Scott C. Ritchie, Parsa Akbari, Tao Jiang, Jason Grealey, Adam S. Butterworth, Willem H. Ouwehand, David J. Roberts, Emanuele Di Angelantonio, John Danesh, Nicole Soranzo, Michael Inouye

    Published 2022-01-01
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  9. 9
    A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.

    A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. by Fumihiko Takeuchi, Ralph McGinnis, Stephane Bourgeois, Chris Barnes, Niclas Eriksson, Nicole Soranzo, Pamela Whittaker, Venkatesh Ranganath, Vasudev Kumanduri, William McLaren, Lennart Holm, Jonatan Lindh, Anders Rane, Mia Wadelius, Panos Deloukas

    Published 2009-03-01
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  10. 10
    Correction: Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits.

    Correction: Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits. by Dirk S. Paul, James P. Nisbet, Tsun-Po Yang, Stuart Meacham, Augusto Rendon, Katta Hautaviita, Jonna Tallila, Jacqui White, Marloes R. Tijssen, Suthesh Sivapalaratnam, Hanneke Basart, Mieke D. Trip, Berthold Göttgens, Nicole Soranzo, Willem H. Ouwehand, Panos Deloukas

    Published 2011-07-01
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  11. 11
    The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue.

    The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue. by Alexander W Drong, George Nicholson, Asa K Hedman, Eshwar Meduri, Elin Grundberg, Kerrin S Small, So-Youn Shin, Jordana T Bell, Fredrik Karpe, Nicole Soranzo, Tim D Spector, Mark I McCarthy, Panos Deloukas, Mattias Rantalainen, Cecilia M Lindgren, MolPAGE Consortia

    Published 2013-01-01
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  12. 12
    Immune disease variants modulate gene expression in regulatory CD4+ T cells

    Immune disease variants modulate gene expression in regulatory CD4+ T cells by Lara Bossini-Castillo, Dafni A. Glinos, Natalia Kunowska, Gosia Golda, Abigail A. Lamikanra, Michaela Spitzer, Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, Claire Cattermole, Kaur Alasoo, Alice Mann, Kousik Kundu, Anna Lorenc, Nicole Soranzo, Ian Dunham, David J. Roberts, Gosia Trynka

    Published 2022-04-01
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  13. 13
    Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits.

    Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits. by Dirk S Paul, James P Nisbet, Tsun-Po Yang, Stuart Meacham, Augusto Rendon, Katta Hautaviita, Jonna Tallila, Jacqui White, Marloes R Tijssen, Suthesh Sivapalaratnam, Hanneke Basart, Mieke D Trip, Cardiogenics Consortium, MuTHER Consortium, Berthold Göttgens, Nicole Soranzo, Willem H Ouwehand, Panos Deloukas

    Published 2011-06-01
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  14. 14
    FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression

    FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression by Kia Joo Puan, Boris San Luis, Nurhashikin Yusof, Dilip Kumar, Anand Kumar Andiappan, Wendy Lee, Samanta Cajic, Dragana Vuckovic, Jing De Chan, Tobias Döllner, Han Wei Hou, Yunxuan Jiang, Chao Tian, the 23andMe Research Team, Erdmann Rapp, Michael Poidinger, De Yun Wang, Nicole Soranzo, Bernett Lee, Olaf Rötzschke

    Published 2021-07-01
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  15. 15
    The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits.

    The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits. by Josine L Min, Jennifer M Taylor, J Brent Richards, Tim Watts, Fredrik H Pettersson, John Broxholme, Kourosh R Ahmadi, Gabriela L Surdulescu, Ernesto Lowy, Christian Gieger, Chris Newton-Cheh, Markus Perola, Nicole Soranzo, Ida Surakka, Cecilia M Lindgren, Jiannis Ragoussis, Andrew P Morris, Lon R Cardon, Tim D Spector, Krina T Zondervan

    Published 2011-01-01
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  16. 16
    Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming

    Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming by Thomas Moreau, Amanda L. Evans, Louella Vasquez, Marloes R. Tijssen, Ying Yan, Matthew W. Trotter, Daniel Howard, Maria Colzani, Meera Arumugam, Wing Han Wu, Amanda Dalby, Riina Lampela, Guenaelle Bouet, Catherine M. Hobbs, Dean C. Pask, Holly Payne, Tatyana Ponomaryov, Alexander Brill, Nicole Soranzo, Willem H. Ouwehand, Roger A. Pedersen, Cedric Ghevaert

    Published 2016-04-01
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  17. 17
    Correction: Corrigendum: Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming

    Correction: Corrigendum: Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming by Thomas Moreau, Amanda L. Evans, Louella Vasquez, Marloes R. Tijssen, Ying Yan, Matthew W. Trotter, Daniel Howard, Maria Colzani, Meera Arumugam, Wing Han Wu, Amanda Dalby, Riina Lampela, Guenaelle Bouet, Catherine M. Hobbs, Dean C. Pask, Holly Payne, Tatyana Ponomaryov, Alexander Brill, Nicole Soranzo, Willem H. Ouwehand, Roger A. Pedersen, Cedric Ghevaert

    Published 2017-07-01
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  18. 18
    Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations

    Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations by Yali Xue, Massimo Mezzavilla, Marc Haber, Shane McCarthy, Yuan Chen, Vagheesh Narasimhan, Arthur Gilly, Qasim Ayub, Vincenza Colonna, Lorraine Southam, Christopher Finan, Andrea Massaia, Himanshu Chheda, Priit Palta, Graham Ritchie, Jennifer Asimit, George Dedoussis, Paolo Gasparini, Aarno Palotie, Samuli Ripatti, Nicole Soranzo, Daniela Toniolo, James F. Wilson, Richard Durbin, Chris Tyler-Smith, Eleftheria Zeggini

    Published 2017-06-01
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  19. 19
    Correction: Identification of Gene for Hip Bone Size Variation in Females in a Genome-Wide Association Study.

    Correction: Identification of Gene for Hip Bone Size Variation in Females in a Genome-Wide Association Study. by Yao-Zhong Liu, Scott G. Wilson, Liang Wang, Xiao-Gang Liu, Yan-Fang Guo, Jian Li, Han Yan, Panos Deloukas, Nicole Soranzo, Usha Chinappen-Horsley, Alessandra Cervino, Frances M. Williams, Dong-Hai Xiong, Yin-Ping Zhang, Tian-Bo Jin, Shawn Levy, Christopher J. Papasian, Betty M. Drees, James J. Hamilton, Robert R. Recker, Tim D. Spector, Hong-Wen Deng

    Published 2009-01-01
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  20. 20
    Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study.

    Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study. by Yao-Zhong Liu, Scott G Wilson, Liang Wang, Xiao-Gang Liu, Yan-Fang Guo, Jian Li, Han Yan, Panos Deloukas, Nicole Soranzo, Usha Chinappen-Horsley, Alessandra Cervino, Frances M Williams, Dong-Hai Xiong, Yin-Ping Zhang, Tian-Bo Jin, Shawn Levy, Christopher J Papasian, Betty M Drees, James J Hamilton, Robert R Recker, Tim D Spector, Hong-Wen Deng

    Published 2008-09-01
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