Kinase inhibitor selectivity profiling using differential scanning fluorimetry. by Fedorov, O, Niesen, F, Knapp, S

Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone. by Zimmermann, T, Niesen, F, Pilka, E, Knapp, S, Oppermann, U, Maier, M

Structure of dystrophia myotonica protein kinase. by Elkins, J, Amos, A, Niesen, F, Pike, A, Fedorov, O, Knapp, S

Structure of dystrophia myotonica protein kinase. by Elkins, J, Amos, A, Niesen, F, Pike, A, Fedorov, O, Knapp, S

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. by Rellos, P, Pike, A, Niesen, F, Salah, E, Lee, W, von Delft, F, Knapp, S

Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder by Froese, D, Healy, S, McDonald, M, Kochan, G, Oppermann, U, Niesen, F, Gravel, R

Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder. by Froese, D, Healy, S, McDonald, M, Kochan, G, Oppermann, U, Niesen, F, Gravel, R

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation by Rellos, P, Pike, A, Niesen, F, Salah, E, Lee, W, Von Delft, F, Knapp, S

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites by Pike, A, Rellos, P, Niesen, F, Turnbull, A, Oliver, A, Parker, S, Turk, B, Pearl, L, Knapp, S

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. by Pike, A, Rellos, P, Niesen, F, Turnbull, A, Oliver, A, Parker, SA, Turk, B, Pearl, L, Knapp, S

Structural basis for substrate specificity in human monomeric carbonyl reductases. by Pilka, E, Niesen, F, Lee, W, El-Hawari, Y, Dunford, J, Kochan, G, Wsol, V, Martin, H, Maser, E, Oppermann, U

Structural basis for substrate specificity in human monomeric carbonyl reductases. by Pilka, E, Niesen, F, Lee, W, El-Hawari, Y, Dunford, J, Kochan, G, Wsol, V, Martin, H, Maser, E, Oppermann, U

High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships. by Niesen, F, Schultz, L, Jadhav, A, Bhatia, C, Guo, K, Maloney, D, Pilka, E, Wang, M, Oppermann, U, Heightman, T, Simeonov, A

Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation by Bullock, A, Das, S, Debreczeni, J, Rellos, P, Fedorov, O, Niesen, F, Guo, K, Papagrigoriou, E, Amos, A, Cho, S, Turk, B, Ghosh, G, Knapp, S

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins. by Gileadi, O, Knapp, S, Lee, W, Marsden, B, Müller, S, Niesen, F, Kavanagh, K, Ball, L, von Delft, F, Doyle, D, Oppermann, U, Sundström, M

Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation. by Bullock, A, Das, S, Debreczeni, J, Rellos, P, Fedorov, O, Niesen, F, Guo, K, Papagrigoriou, E, Amos, A, Cho, S, Turk, B, Ghosh, G, Knapp, S

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation. by Lucic, B, Zhang, Y, King, O, Mendoza-Maldonado, R, Berti, M, Niesen, F, Burgess-Brown, N, Pike, A, Cooper, C, Gileadi, O, Vindigni, A

Conformational stability and activity of p73 require a second helix in the tetramerization domain. by Coutandin, D, Löhr, F, Niesen, F, Ikeya, T, Weber, T, Schäfer, B, Zielonka, E, Bullock, A, Yang, A, Güntert, P, Knapp, S, McKeon, F, Ou, H, Dötsch, V

Conformational stability and activity of p73 require a second helix in the tetramerization domain. by Coutandin, D, Löhr, F, Niesen, F, Ikeya, T, Weber, T, Schäfer, B, Zielonka, E, Bullock, A, Yang, A, Güntert, P, Knapp, S, McKeon, F, Ou, H, Dötsch, V

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. by Vedadi, M, Niesen, F, Allali-Hassani, A, Fedorov, O, Finerty, P, Wasney, G, Yeung, R, Arrowsmith, C, Ball, L, Berglund, H, Hui, R, Marsden, B, Nordlund, P, Sundstrom, M, Weigelt, J, Edwards, A