Group sequential designs for pragmatic clinical trials with early outcomes: methods and guidance for planning and implementation ‌ Nick R. Parsons, Joydeep Basu, Nigel Stallard

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Comparison of Bayesian and frequentist group-sequential clinical trial designs ‌ Nigel Stallard, Susan Todd, Elizabeth G. Ryan, Simon Gates

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Statistical consideration when adding new arms to ongoing clinical trials: the potentials and the caveats ‌ Kim May Lee, Louise C. Brown, Thomas Jaki, Nigel Stallard, James Wason

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An adaptive two-arm clinical trial using early endpoints to inform decision making: design for a study of sub-acromial spacers for repair of rotator cuff tendon tears ‌ Nick Parsons, Nigel Stallard, Helen Parsons, Philip Wells, Martin Underwood, James Mason, Andrew Metcalfe

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Bayesian group sequential designs for phase III emergency medicine trials: a case study using the PARAMEDIC2 trial ‌ Elizabeth G. Ryan, Nigel Stallard, Ranjit Lall, Chen Ji, Gavin D. Perkins, Simon Gates

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Optimizing Trial Designs for Targeted Therapies. ‌ Thomas Ondra, Sebastian Jobjörnsson, Robert A Beckman, Carl-Fredrik Burman, Franz König, Nigel Stallard, Martin Posch

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Value of information methods to design a clinical trial in a small population to optimise a health economic utility function ‌ Michael Pearce, Siew Wan Hee, Jason Madan, Martin Posch, Simon Day, Frank Miller, Sarah Zohar, Nigel Stallard

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Investigating interventions to increase uptake of HIV testing and linkage into care or prevention for male partners of pregnant women in antenatal clinics in Blantyre, Malawi: stud... ‌ Augustine T. Choko, Katherine Fielding, Nigel Stallard, Hendramoorthy Maheswaran, Aurelia Lepine, Nicola Desmond, Moses K. Kumwenda, Elizabeth L. Corbett

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Using Bayesian adaptive designs to improve phase III trials: a respiratory care example ‌ Elizabeth G. Ryan, Julie Bruce, Andrew J. Metcalfe, Nigel Stallard, Sarah E. Lamb, Kert Viele, Duncan Young, Simon Gates

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Identification of subgroup effect with an individual participant data meta-analysis of randomised controlled trials of three different types of therapist-delivered care in low back... ‌ Siew Wan Hee, Dipesh Mistry, Tim Friede, Sarah E. Lamb, Nigel Stallard, Martin Underwood, Shilpa Patel, On behalf of the Repository Group

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Recommendations for the design of small population clinical trials ‌ Simon Day, Anneliene Hechtelt Jonker, Lilian Pek Lian Lau, Ralf-Dieter Hilgers, Ilan Irony, Kristina Larsson, Kit CB Roes, Nigel Stallard

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HIV self-testing alone or with additional interventions, including financial incentives, and linkage to care or prevention among male partners of antenatal care clinic attendees in... ‌ Augustine T Choko, Elizabeth L Corbett, Nigel Stallard, Hendramoorthy Maheswaran, Aurelia Lepine, Cheryl C Johnson, Doreen Sakala, Thokozani Kalua, Moses Kumwenda, Richard Hayes, Katherine Fielding

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Statistical analysis plan for the motor neuron disease systematic multi-arm adaptive randomised trial (MND-SMART) ‌ Richard A. Parker, Christopher J. Weir, Tra My Pham, Ian R. White, Nigel Stallard, Mahesh K. B. Parmar, Robert J. Swingler, Rachel S. Dakin, Suvankar Pal, Siddharthan Chandran

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Randomised controlled trial evaluating the effectiveness and cost-effectiveness of ‘Families for Health’, a family-based childhood obesity treatment intervention delivered in a com... ‌ Wendy Robertson, Joanna Fleming, Atiya Kamal, Thomas Hamborg, Kamran A Khan, Frances Griffiths, Sarah Stewart-Brown, Nigel Stallard, Stavros Petrou, Douglas Simkiss, Elizabeth Harrison, Sung Wook Kim, Margaret Thorogood

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Group sequential designs in pragmatic trials: feasibility and assessment of utility using data from a number of recent surgical RCTs ‌ Nick R. Parsons, Nigel Stallard, Helen Parsons, Aminul Haque, Martin Underwood, James Mason, Iftekhar Khan, Matthew L. Costa, Damian R. Griffin, James Griffin, David J. Beard, Jonathan A. Cook, Loretta Davies, Jemma Hudson, Andrew Metcalfe

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Protocol for a randomised controlled trial of Subacromial spacer for Tears Affecting Rotator cuff Tendons: a Randomised, Efficient, Adaptive Clinical Trial in Surgery (START:REACTS... ‌ Martin Underwood, Nicholas Parsons, Helen Parsons, Jaclyn Brown, James Mason, Simon Gates, Andrew Metcalfe, Elke Gemperle Mannion, Josephine Fox, Rebecca Kearney, Tom Lawrence, Howard Bush, Kerri McGowan, Iftekhar Khan, Charles Hutchinson, Nigel Stallard, Stephen Drew

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Facet joint injections for people with persistent non-specific low back pain (Facet Injection Study): a feasibility study for a randomised controlled trial ‌ David R Ellard, Martin Underwood, Felix Achana, James HL Antrobus, Shyam Balasubramanian, Sally Brown, Melinda Cairns, James Griffin, Frances Griffiths, Kirstie Haywood, Charles Hutchinson, Ranjit Lall, Stavros Petrou, Nigel Stallard, Colin Tysall, David A Walsh, Harbinder Sandhu

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Identifying back pain subgroups: developing and applying approaches using individual patient data collected within clinical trials ‌ Shilpa Patel, Siew Wan Hee, Dipesh Mistry, Jake Jordan, Sally Brown, Melina Dritsaki, David R Ellard, Tim Friede, Sarah E Lamb, Joanne Lord, Jason Madan, Tom Morris, Nigel Stallard, Colin Tysall, Adrian Willis, Martin Underwood, the Repository Group

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Breast screening atypia and subsequent development of cancer: protocol for an observational analysis of the Sloane database in England (Sloane atypia cohort study) ‌ Abeer M Shaaban, Karoline Freeman, Sian Taylor-Phillips, Nisha Sharma, Olive Kearins, Cliona Kirwan, Karen Clements, Nigel Stallard, Alastair M Thompson, David Jenkinson, Hilary Stobart, Sarah Pinder, Elena Provenzano, Matthew G Wallis, Bridget Hilton, Joanne Dulson-Cox, Samantha McDonnell

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OPTIMA prelim: a randomised feasibility study of personalised care in the treatment of women with early breast cancer ‌ Robert C Stein, Janet A Dunn, John MS Bartlett, Amy F Campbell, Andrea Marshall, Peter Hall, Leila Rooshenas, Adrienne Morgan, Christopher Poole, Sarah E Pinder, David A Cameron, Nigel Stallard, Jenny L Donovan, Christopher McCabe, Luke Hughes-Davies, Andreas Makris, on behalf of the OPTIMA Trial Management Group

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