Fibroblasts in Orchestrating Colorectal Tumorigenesis and ProgressionSummary by Subinuer Abudukelimu, Noel F.C.C. de Miranda, Lukas J.A.C. Hawinkels

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PENGUIN: A rapid and efficient image preprocessing tool for multiplexed spatial proteomics by A.M. Sequeira, M.E. Ijsselsteijn, M. Rocha, Noel F.C.C. de Miranda

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Linking Immunity with Genomics in Sarcomas: Is Genomic Complexity an Immunogenic Trigger? by Siddh van Oost, Debora M. Meijer, Marieke L. Kuijjer, Judith V. M. G. Bovée, Noel F. C. C. de Miranda

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Mass Cytometric Analysis of Early-Stage Mycosis Fungoides by Nannan Guo, Li Jia, Coby Out-Luiting, Noel F. C. C. de Miranda, Rein Willemze, Frits Koning, Maarten Vermeer, Koen Quint

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Local and systemic immune profiles of human pancreatic ductal adenocarcinoma revealed by single-cell mass cytometry by Zheng Li, Frits Koning, Natasja L de Vries, Tamim Abdelaal, Boudewijn P F Lelieveldt, Noel F C C de Miranda, Hans Morreau, Dina Ruano, Alexander L Vahrmeijer, Bert A Bonsing, Thomas P Brouwer, Ricki T Krog, Arantza Fariña

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Immune subset-committed proliferating cells populate the human foetal intestine throughout the second trimester of gestation by Nannan Guo, Na Li, Li Jia, Qinyue Jiang, Mette Schreurs, Vincent van Unen, Susana M. Chuva de Sousa Lopes, Alexandra A. Vloemans, Jeroen Eggermont, Boudewijn Lelieveldt, Frank J. T. Staal, Noel F. C. C. de Miranda, M. Fernanda Pascutti, Frits Koning

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Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival by Sjoerd H van der Burg, Thomas Höllt, Ziena Abdulrahman, Marieke E Ijsselsteijn, Noel F C C de Miranda, Dana A M Mustafa, Marij J P Welters, Zlatko Trajanoski, Saskia J Santegoets, Pornpimol Charoentong, Gregor Sturm, Antonios Somarakis, Francesca Finotello, Sylvia L van Egmond

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Targeting epigenetic regulation and post-translational modification with 5-Aza-2’ deoxycytidine and SUMO E1 inhibition augments T-cell receptor therapy by Marieke Griffioen, Noel F C C de Miranda, Sumit Kumar, Jessie S Kroonen, Ilona J de Graaf, Alfred C O Vertegaal, Tassilo L A Wachsmann, Anne K Wouters, Dennis F G Remst, Mirjam H M Heemskerk, Jessica P Roelands, Amina F A S Teunisse

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CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden by Sjoerd H van der Burg, Rebekka Duhen, Thomas Duhen, Marieke E Ijsselsteijn, Ruud van der Breggen, Koen C M J Peeters, Noel F C C de Miranda, Els M E Verdegaal, Dina Ruano, Manon van der Ploeg, Jitske van den Bulk, Arantza Fariña-Sarasqueta

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The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer by Giulia Trimaglio, Tamara Sneperger, Benjamin B. A. Raymond, Nelly Gilles, Emmanuelle Näser, Marie Locard-Paulet, Marieke E. Ijsselsteijn, Thomas P. Brouwer, Romain Ecalard, Jessica Roelands, Naoki Matsumoto, André Colom, Myriam Habch, Noel F. C. C. de Miranda, Nathalie Vergnolle, Christel Devaud, Olivier Neyrolles, Yoann Rombouts

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Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy by Sjoerd H van der Burg, Suzanne van Duikeren, Ramon Arens, Thorbald van Hall, Ziena Abdulrahman, Elham Beyranvand Nejad, Jan Willem Kleinovink, Noel F C C de Miranda, Camilla Labrie, Marit J van Elsas, Eva Rademaker, Tetje C van der Sluis, Amina F A.S Teunisse, Aart G Jochemsen, Jan Oosting

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Germline variant affecting p53β isoforms predisposes to familial cancer by Stephanie A. Schubert, Dina Ruano, Sebastien M. Joruiz, Jordy Stroosma, Nikolina Glavak, Anna Montali, Lia M. Pinto, Mar Rodríguez-Girondo, Daniela Q. C. M. Barge-Schaapveld, Maartje Nielsen, Bernadette P. M. van Nesselrooij, Arjen R. Mensenkamp, Monique E. van Leerdam, Thomas H. Sharp, Hans Morreau, Jean-Christophe Bourdon, Noel F. C. C. de Miranda, Tom van Wezel

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Cancer-Associated Fibroblasts Are Key Determinants of Cancer Cell Invasion in the Earliest Stage of Colorectal CancerSummary by Hao Dang, Tom J. Harryvan, Chen-Yi Liao, Erik H.J. Danen, Vienna N.L.N. Spalburg, Szymon M. Kielbasa, Hailiang Mei, Jelle J. Goeman, Eveline S. de Jonge-Muller, Stefanus G.T. Janson, Johan J. van der Reijden, Stijn Crobach, James C.H. Hardwick, Jurjen J. Boonstra, Noel F.C.C. de Miranda, Lukas J.A.C. Hawinkels

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Multimodal profiling of chordoma immunity reveals distinct immune contextures by Marieke E Ijsselsteijn, Ruud van der Breggen, Noel F C C de Miranda, Wilco C Peul, Judith V M G Bovée, Manon van der Ploeg, Siddh van Oost, Debora M Meijer, Jessica P Roelands, Brendy E M W van den Akker, Inge H Briaire-de Bruijn, Pauline M Wijers-Koster, Samuel B Polak, Robert J P van der Wal

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Imaging mass cytometry reveals the prominent role of myeloid cells at the maternal-fetal interface by Juliette Krop, Anita van der Zwan, Marieke E. Ijsselsteijn, Hanneke Kapsenberg, Sietse J. Luk, Sanne H. Hendriks, Carin van der Keur, Lotte J. Verleng, Antonis Somarakis, Lotte van der Meeren, Geert Haasnoot, Manon Bos, Noel F.C.C. de Miranda, Susana M. Chuva de Sousa Lopes, Marie-Louise P. van der Hoorn, Frits Koning, Frans H.J. Claas, Sebastiaan Heidt, Michael Eikmans

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Location matters: spatial dynamics of tumor-infiltrating T cell subsets is prognostic in colon cancer by Hehuan Zhu, Jessica Roelands, Jessica Roelands, Jessica Roelands, Eiman I. Ahmed, Eiman I. Ahmed, Eiman I. Ahmed, Imke Stouten, Rachel Hoorntje, Ronald L. P. van Vlierberghe, Marieke E. Ijsselsteijn, Xin Lei, Noel F. C. C. de Miranda, Rob A. E. M. Tollenaar, Alexander L. Vahrmeijer, Davide Bedognetti, Davide Bedognetti, Wouter R. L. Hendrickx, Wouter R. L. Hendrickx, Peter J. K. Kuppen

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Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer by Christina Plattner, Giorgia Lamberti, Peter Blattmann, Alexander Kirchmair, Dietmar Rieder, Zuzana Loncova, Gregor Sturm, Stefan Scheidl, Marieke Ijsselsteijn, Georgios Fotakis, Asma Noureen, Rebecca Lisandrelli, Nina Böck, Niloofar Nemati, Anne Krogsdam, Sophia Daum, Francesca Finotello, Antonios Somarakis, Alexander Schäfer, Doris Wilflingseder, Miguel Gonzalez Acera, Dietmar Öfner, Lukas A. Huber, Hans Clevers, Christoph Becker, Henner F. Farin, Florian R. Greten, Ruedi Aebersold, Noel F.C.C. de Miranda, Zlatko Trajanoski

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B cell immune profiles in dysbiotic vermiform appendixes of pancreatic cancer patients by Eveline E. Vietsch, Eveline E. Vietsch, Diba Latifi, Maaike Verheij, Elise W.A. van der Oost, Roeland F. de Wilde, Roel Haen, Anne Loes van den Boom, Anne Loes van den Boom, Bas Groot Koerkamp, Pascal G. Doornebosch, Victorien M.T. van Verschuer, Ariadne H.A.G. Ooms, Ariadne H.A.G. Ooms, Farzana Mohammad, Marcella Willemsen, Joachim G.J.V. Aerts, Ricki T. Krog, Noel F.C.C. de Miranda, Thierry P.P. van den Bosch, Yvonne M. Mueller, Peter D. Katsikis, Casper H.J. van Eijck

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