Fibroblasts in Orchestrating Colorectal Tumorigenesis and ProgressionSummary 由 Subinuer Abudukelimu, Noel F.C.C. de Miranda, Lukas J.A.C. Hawinkels

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PENGUIN: A rapid and efficient image preprocessing tool for multiplexed spatial proteomics 由 A.M. Sequeira, M.E. Ijsselsteijn, M. Rocha, Noel F.C.C. de Miranda

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Linking Immunity with Genomics in Sarcomas: Is Genomic Complexity an Immunogenic Trigger? 由 Siddh van Oost, Debora M. Meijer, Marieke L. Kuijjer, Judith V. M. G. Bovée, Noel F. C. C. de Miranda

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A 40-Marker Panel for High Dimensional Characterization of Cancer Immune Microenvironments by Imaging Mass Cytometry 由 Marieke E. Ijsselsteijn, Ruud van der Breggen, Arantza Farina Sarasqueta, Frits Koning, Frits Koning, Noel F. C. C. de Miranda

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Mass Cytometric Analysis of Early-Stage Mycosis Fungoides 由 Nannan Guo, Li Jia, Coby Out-Luiting, Noel F. C. C. de Miranda, Rein Willemze, Frits Koning, Maarten Vermeer, Koen Quint

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Unraveling the Complexity of the Cancer Microenvironment With Multidimensional Genomic and Cytometric Technologies 由 Natasja L. de Vries, Natasja L. de Vries, Ahmed Mahfouz, Ahmed Mahfouz, Ahmed Mahfouz, Frits Koning, Noel F. C. C. de Miranda

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PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors 由 Guillaume Beyrend, Esmé van der Gracht, Ayse Yilmaz, Suzanne van Duikeren, Marcel Camps, Thomas Höllt, Anna Vilanova, Vincent van Unen, Frits Koning, Noel F. C. C. de Miranda, Ramon Arens, Ferry Ossendorp

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Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients 由 Boyd Kenkhuis, Antonios Somarakis, Lorraine de Haan, Oleh Dzyubachyk, Marieke E. IJsselsteijn, Noel F. C. C. de Miranda, Boudewijn P. F. Lelieveldt, Jouke Dijkstra, Willeke M. C. van Roon-Mom, Thomas Höllt, Louise van der Weerd

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Local and systemic immune profiles of human pancreatic ductal adenocarcinoma revealed by single-cell mass cytometry 由 Zheng Li, Frits Koning, Natasja L de Vries, Tamim Abdelaal, Boudewijn P F Lelieveldt, Noel F C C de Miranda, Hans Morreau, Dina Ruano, Alexander L Vahrmeijer, Bert A Bonsing, Thomas P Brouwer, Ricki T Krog, Arantza Fariña

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A 34-Marker Panel for Imaging Mass Cytometric Analysis of Human Snap-Frozen Tissue 由 Nannan Guo, Vincent van Unen, Vincent van Unen, Marieke E. Ijsselsteijn, Laura F. Ouboter, Andrea E. van der Meulen, Susana M. Chuva de Sousa Lopes, Noel F. C. C. de Miranda, Frits Koning, Na Li, Na Li

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Immune subset-committed proliferating cells populate the human foetal intestine throughout the second trimester of gestation 由 Nannan Guo, Na Li, Li Jia, Qinyue Jiang, Mette Schreurs, Vincent van Unen, Susana M. Chuva de Sousa Lopes, Alexandra A. Vloemans, Jeroen Eggermont, Boudewijn Lelieveldt, Frank J. T. Staal, Noel F. C. C. de Miranda, M. Fernanda Pascutti, Frits Koning

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Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival 由 Sjoerd H van der Burg, Thomas Höllt, Ziena Abdulrahman, Marieke E Ijsselsteijn, Noel F C C de Miranda, Dana A M Mustafa, Marij J P Welters, Zlatko Trajanoski, Saskia J Santegoets, Pornpimol Charoentong, Gregor Sturm, Antonios Somarakis, Francesca Finotello, Sylvia L van Egmond

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Targeting epigenetic regulation and post-translational modification with 5-Aza-2’ deoxycytidine and SUMO E1 inhibition augments T-cell receptor therapy 由 Marieke Griffioen, Noel F C C de Miranda, Sumit Kumar, Jessie S Kroonen, Ilona J de Graaf, Alfred C O Vertegaal, Tassilo L A Wachsmann, Anne K Wouters, Dennis F G Remst, Mirjam H M Heemskerk, Jessica P Roelands, Amina F A S Teunisse

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CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden 由 Sjoerd H van der Burg, Rebekka Duhen, Thomas Duhen, Marieke E Ijsselsteijn, Ruud van der Breggen, Koen C M J Peeters, Noel F C C de Miranda, Els M E Verdegaal, Dina Ruano, Manon van der Ploeg, Jitske van den Bulk, Arantza Fariña-Sarasqueta

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The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer 由 Giulia Trimaglio, Tamara Sneperger, Benjamin B. A. Raymond, Nelly Gilles, Emmanuelle Näser, Marie Locard-Paulet, Marieke E. Ijsselsteijn, Thomas P. Brouwer, Romain Ecalard, Jessica Roelands, Naoki Matsumoto, André Colom, Myriam Habch, Noel F. C. C. de Miranda, Nathalie Vergnolle, Christel Devaud, Olivier Neyrolles, Yoann Rombouts

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Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy 由 Sjoerd H van der Burg, Suzanne van Duikeren, Ramon Arens, Thorbald van Hall, Ziena Abdulrahman, Elham Beyranvand Nejad, Jan Willem Kleinovink, Noel F C C de Miranda, Camilla Labrie, Marit J van Elsas, Eva Rademaker, Tetje C van der Sluis, Amina F A.S Teunisse, Aart G Jochemsen, Jan Oosting

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Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4 由 Jitske van den Bulk, Els M. E. Verdegaal, Dina Ruano, Marieke E. Ijsselsteijn, Marten Visser, Ruud van der Breggen, Thomas Duhen, Manon van der Ploeg, Natasja L. de Vries, Jan Oosting, Koen C. M. J. Peeters, Andrew D. Weinberg, Arantza Farina-Sarasqueta, Sjoerd H. van der Burg, Noel F. C. C. de Miranda

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Immune-based biomarker accurately predicts response to imiquimod immunotherapy in cervical high-grade squamous intraepithelial lesions 由 Natasja Hendriks, Sjoerd H van der Burg, Ziena Abdulrahman, Noel F C C de Miranda, Edith M G van Esch, Peggy J de Vos van Steenwijk, Antonios Somarakis, Arnold J Kruse, Anna J M van de Sande, Heleen J van Beekhuizen, Jurgen M J Piek, Loes F S Kooreman, Brigitte F M Slangen

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Tumor-Infiltrating T Cells Can Be Expanded Successfully from Primary Uveal Melanoma after Separation from Their Tumor Environment 由 Gülçin Gezgin, MD, Marten Visser, MSc, Dina Ruano, PhD, Saskia J. Santegoets, PhD, Noel F.C.C. de Miranda, PhD, Pieter A. van der Velden, PhD, Gregorius P.M. Luyten, MD, PhD, Sjoerd H. van der Burg, PhD, Els M. Verdegaal, PhD, Martine J. Jager, MD, PhD

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Germline variant affecting p53β isoforms predisposes to familial cancer 由 Stephanie A. Schubert, Dina Ruano, Sebastien M. Joruiz, Jordy Stroosma, Nikolina Glavak, Anna Montali, Lia M. Pinto, Mar Rodríguez-Girondo, Daniela Q. C. M. Barge-Schaapveld, Maartje Nielsen, Bernadette P. M. van Nesselrooij, Arjen R. Mensenkamp, Monique E. van Leerdam, Thomas H. Sharp, Hans Morreau, Jean-Christophe Bourdon, Noel F. C. C. de Miranda, Tom van Wezel

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