Are large clinical trials in orthopaedic trauma justified? by Sprague, S, Tornetta, P, Slobogean, GP, O'Hara, NN, McKay, P, Petrisor, B, Jeray, KJ, Schemitsch, EH, Sanders, D, Bhandari, M, Guyatt, GH, Walter, S, Anglen, J, Bosse, M, Liew, S, Sancheti, P, Tai, K, Heels-Ansdell, D, Buckingham, L, Duraikannan, A, Tanner, SL, Snider, RG, Altman, D, Gandhi, R, Bischoff, M, Della Rocca, GJ, Ristevski, B, Rajaratnam, K, Williams, D, Denkers, M, Bednar, D, Sadler, J, Kwok, D, Drew, B, Wong, I, Madden, K, Hall, JA, McKee, MD, Ahn, H, Whelan, D, Waddell, J, Daniels, T, Bogoch, E, Nauth, A, Vicente, MR, Hidy, JT, Lawendy, AR, Gurr, K, Carey, T, Bailey, C, MacLeod, M, Bartley, D, Tieszer, C, Coles, C, Leighton, R, Richardson, CG, Biddulph, M, Gross, M, Dunbar, M, Amirault, JD, Alexander, D, Coady, C, Glazebrook, M, Johnston, D, Oxner, W, Trenholm, JA, Reardon, G, Trask, K, MacDonald, S, Papp, S, Gofton, W, Liew, A, Kingwell, S, O'Neill, J, Johnson, G, Wai, E, Foxall, J, Broekhuyse, HM, O'Brien, PJ, Blachut, PA, Lefaivre, KA, Johal, R, Leduc, S, Laflamme, GY, Beaumont, P, Malo, M, Benoit, B, Rouleau, D, Ranger, P, Fournier, J, Tardif, K, Reindl, R