P597: HIGH DOSE IRON IMPAIRS MALIGNANT B-CELL VIABILITY IN CHRONIC LYMPHOCYTIC LEUKEMIA by J. Bordini, C. Lenzi, L. Toscani, P. Ranghetti, E. Perotta, L. Scarfò, P. Ghia, A. Campanella

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PB2362: BEST PRACTICES ON EMPOWERING AND INVOLVING PATIENTS LIVING WITH HEMATOLOGICAL MALIGNANCIES ON THE DEVELOPMENT OF NOVEL PATIENT-REPORTED OUTCOME MEASURES by N. Vrontaras, D. Kyrou, A. Kapetanakis, D. Tsakona, C. Karamanidou, L. Scarfò, P. Ghia, K. Stamatopoulos

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P616: THE LOSS OF IΚBΕ INHIBITOR ACCELERATES DISEASE DEVELOPMENT IN CHRONIC LYMPHOCYTIC LEUKEMIA by C. Lenzi, J. Bordini, A. Pseftogkas, A. Morabito, G. Tsiolas, F. E. Psomopoulos, A. Campanella, M. Frenquelli, P. Ghia

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GENOMIC EVOLUTION AND RESISTANCE TO PIRTOBRUTINIB IN COVALENT BTK-INHIBITOR PRE-TREATED CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS: RESULTS FROM THE PHASE I/II BRUIN STUDY by JR Brown, JA Woyach, K Patel, TA Eyre, Cy Cheah, P Ghia, W Jurczak, P Abada, WG Wierda, GFPN Presenter

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P667: LONG-TERM EFFICACY OF ACALABRUTINIB-BASED REGIMENS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AND HIGHER-RISK GENOMIC FEATURES: POOLED ANALYSIS OF CLINICAL TRIAL DATA by M. Davids, J. Sharman, P. Ghia, J. Woyach, W. Jurczak, T. Siddiqi, P. Miranda, M. Shahkarami, T. Yu, U. Emeribe, J. Byrd

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P662: PATIENT-REPORTED OUTCOMES FROM A PHASE 3 RANDOMIZED STUDY OF ZANUBRUTINIB VERSUS BENDAMUSTINE PLUS RITUXIMAB (BR) IN PATIENTS WITH TREATMENT-NAÏVE (TN) CLL/SLL by P. Ghia, G. Barnes, K. Yang, C. Tam, P. Hillmen, T. Robak, J. Brown, B. Kahl, T. Tian, A. Szeto, J. Paik, M. Shadman

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PB1864: BRUIN CLL-321: A PHASE 3 OPEN-LABEL, RANDOMIZED STUDY OF PIRTOBRUTINIB VS INVESTIGATOR’S CHOICE OF IDELALISIB+RITUXIMAB OR BENDAMUSTINE+RITUXIMAB IN BTKI PRETREATED CLL/SLL... by J. P. Sharman, W. Jurczak, C. C. Coombs, M. Hill, D. Wang, N. C. Ku, A. Guntur, S. Shahda, C. C. Leow, P. Ghia, A. R. Mato

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PB2349: LESSONS LEARNED FROM THE MYPAL DIGITAL HEALTH INTERVENTION: CAPITALIZING ON THE PATIENT REPORTED OUTCOMES (PRO) PARADIGM TOWARDS A PARTICIPATORY HEALTHCARE FOR PATIENTS WIT... by C. Karamanidou, L. Scarfò, M. Doubek, S. Garani-Papadatos, J. Didi, C. Pontikoglou, E. Kazantzaki, J. Ling, C. Pain, H. Papadaki, R. Rosenquist, N. Stavroyianni, S. Payne, P. Ghia, K. Stamatopoulos, P. Natsiavas

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PB1878: CROSS-TRIAL ANALYSIS OF FIXED-DURATION IBRUTINIB (I) PLUS VENETOCLAX (V) VS FLUDARABINE (F), CYCLOPHOSPHAMIDE (C), AND RITUXIMAB (R) AS FIRST-LINE TREATMENT FOR CHRONIC LYM... by J. C. Barrientos, P. M. Barr, A. R. Mato, C. S. Tam, P. Ghia, C. Moreno, N. E. Kay, T. Siddiqi, E. Szafer-Glusman, C. Zhou, L. Neumayr, G. Krigsfeld, W. G. Wierda, T. Shanafelt

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P1463: PHASE I DOSE ESCALATION OF LAVA-051, A NOVEL BISPECIFIC GAMMA-DELTA T-CELL ENGAGER (GAMMABODY™), IN RELAPSED/REFRACTORY HEMATOLOGICAL MALIGNANCIES by A. Broijl, N. van de Donk, F. Bosch, M. V. Mateos, P. Rodriguez-Otero, A. Tucci, P. Ghia, A. Adang, P. Parren, I. Tuinhof, S. Umarale, B. Winograd, H. van der Vliet, A. Kater

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P593: MULTIDIMENSIONAL ANALYSIS OF THE B CELL RECEPTOR OFFERS INSIGHT INTO THE ONTOGENETIC RELATIONSHIP OF MONOCLONAL B-CELL LYMPHOCYTOSIS WITH CHRONIC LYMPHOCYTIC LEUKEMIA by A. Agathangelidis, C. Galigalidou, A. Iatrou, L. Zaragoza-Infante, L. Scarfò, M. C. Maniou, P. Ranghetti, N. Pechlivanis, V. Junet, A. Skaftason, M. Tsagiopoulou, F. Psomopoulos, R. Rosenquist, P. Ghia, A. Chatzidimitriou, K. Stamatopoulos

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P668: ACALABRUTINIB VS RITUXIMAB PLUS IDELALISIB OR BENDAMUSTINE IN RELAPSED/REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA: ASCEND RESULTS AT ~4 YEARS OF FOLLOW-UP by P. Ghia, A. Pluta, M. Wach, D. Lysak, M. Simkovic, I. Kriachok, A. Illes, J. de la Serna, S. Dolan, P. Campbell, G. Musuraca, A. Jacob, E. Avery, J. H. Lee, G. Usenko, M. H. Wang, T. Yu, W. Jurczak

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P669: FIXED-DURATION (FD) IBRUTINIB + VENETOCLAX FOR FIRST-LINE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)/SMALL LYMPHOCYTIC LYMPHOMA (SLL): 3-YEAR FOLLOW-UP FROM THE PHASE 2... by C. Moreno, W. G. Wierda, P. M. Barr, T. Siddiqi, J. N. Allan, T. J. Kipps, L. Trentin, R. Jacobs, S. Jackson, A. Tedeschi, S. Opat, R. Bannerji, B. J. Kuss, L. J. Croner, E. Szafer-Glusman, C. Zhou, A. Szoke, J. P. Dean, P. Ghia, C. S. Tam

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P666: ACALABRUTINIB ± OBINUTUZUMAB VS OBINUTUZUMAB + CHLORAMBUCIL IN TREATMENT-NAIVE CHRONIC LYMPHOCYTIC LEUKEMIA: 5-YEAR FOLLOW-UP OF ELEVATE-TN by J. P. Sharman, M. Egyed, W. Jurczak, A. Skarbnik, K. Patel, I. W. Flinn, M. Kamdar, T. Munir, R. Walewska, L. M. Fogliatto, Y. Herishanu, V. Banerji, G. Follows, P. Walker, K. Karlsson, P. Ghia, A. Janssens, F. Cymbalista, E. Ferrant, W. G. Wierda, V. Munugalavadla, T. Yu, M. H. Wang, J. A. Woyach

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S147: PIRTOBRUTINIB, A HIGHLY SELECTIVE, NON-COVALENT (REVERSIBLE) BTK INHIBITOR IN PREVIOUSLY TREATED CLL/SLL: UPDATED RESULTS FROM THE PHASE 1/2 BRUIN STUDY by A. R. Mato, J. M. Pagel, C. C. Coombs, N. N. Shah, N. Lamanna, T. Munir, E. Lech-Maranda, T. A. Eyre, J. A. Woyach, W. G. Wierda, C. Y. Cheah, J. B. Cohen, L. E. Roeker, M. R. Patel, B. Fakhri, M. A. Barve, C. Tam, D. Lewis, J. N. Gerson, A. J. Alencar, C. Ujjani, I. Flinn, S. Sundaram, S. Ma, D. Jagadeesh, J. Rhodes, J. Taylor, O. Abdel-Wahab, P. Ghia, S. J. Schuster, D. Wang, B. Nair, E. Zhu, D. E. Tsai, M. S. Davids, J. R. Brown, W. Jurczak

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P1101: PIRTOBRUTINIB, A HIGHLY SELECTIVE, NON-COVALENT (REVERSIBLE) BTK INHIBITOR IN PREVIOUSLY TREATED MANTLE CELL LYMPHOMA: UPDATED RESULTS FROM THE PHASE 1/2 BRUIN STUDY by T. A. Eyre, M. L. Wang, N. N. Shah, A. J. Alencar, J. N. Gerson, M. R. Patel, B. Fakhri, E. Vandenberghe, W. Jurczak, X. N. Tan, K. L. Lewis, T. Fenske, Y. Wang, C. C. Coombs, I. Flinn, D. Lewis, S. Le Gouill, M. Gandhi, C. Chay, M. L. Palomba, J. A. Woyach, J. M. Pagel, N. Lamanna, J. P. Sharman, D. J. Andorsky, J. B. Cohen, M. A. Barve, P. Ghia, M. Yin, P. L. Zinzani, C. Ujjani, Y. Koh, K. Izutsu, E. Lech-Maranda, J. Kherani, C. Tam, S. Sundaram, B. Nair, D. E. Tsai, M. Balbas, A. R. Mato, C. Y. Cheah

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P1282: DISEASE-SPECIFIC U1 SPLICEOSOMAL RNA MUTATIONS IN MATURE B-CELL NEOPLASMS by F. Nadeu, S. Shuai, G. Clot, L. K. Hilton, A. Diaz-Navarro, S. Martín, R. Royo, T. Baumann, M. Kulis, I. López-Oreja, M. Cossio, J. Lu, V. Ljungström, E. Young, K. Plevova, B. A. Knisbacher, Z. Lin, C. K. Hahn, P. Bousquets, M. Alcoceba, M. González, E. Colado, M. Aymerich, M. J. Terol, A. Rivas-Delgado, A. Enjuanes, S. Ruiz-Gaspà, T. Chatzikonstantinou, D. Hägerstrand, C. Jylhä, A. Skaftason, L. Mansouri, K. Stranska, M. Doubek, E. J. van Gastel-Mol, Z. Davis, R. Walewska, L. Scarfò, L. Trentin, A. Visentin, S. A. Parikh, K. G. Rabe, R. Moia, M. Armand, D. Rossi, F. Davi, G. Gaidano, N. E. Kay, T. Shanafelt, P. Ghia, D. Oscier, A. W. Langerak, S. Beà, A. López-Guillermo, D. Neuberg, C. J. Wu, G. Getz, S. Pospisilova, K. Stamatopoulos, R. Rosenquist, W. Huber, T. Zenz, D. Colomer, J. I. Martín-Subero, J. Delgado, R. D. Morin, L. D. Stein, X. S. Puente, E. Campo

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