Designing and analyzing clinical trials with composite outcomes: consideration of possible treatment differences between the individual outcomes. by Janice Pogue, P J Devereaux, Lehana Thabane, Salim Yusuf

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Assessment and implication of prognostic imbalance in randomized controlled trials with a binary outcome--a simulation study. by Rong Chu, Stephen D Walter, Gordon Guyatt, P J Devereaux, Michael Walsh, Kristian Thorlund, Lehana Thabane

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Conversion between B-type natriuretic peptide and N-terminal pro B-type natriuretic peptide in perioperative risk assessment: protocol for a prospective cohort study by P J Devereaux, Ben King, Pavel S Roshanov, Jordan Leitch, Joel Parlow, Deborah DuMerton, Taryn Davidson

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Simple compared to covariate-constrained randomization methods in balancing baseline characteristics: a case study of randomly allocating 72 hemodialysis centers in a cluster trial by Ahmed A. Al-Jaishi, Stephanie N. Dixon, Eric McArthur, P. J. Devereaux, Lehana Thabane, Amit X. Garg

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Double-adjustment in propensity score matching analysis: choosing a threshold for considering residual imbalance by Tri-Long Nguyen, Gary S. Collins, Jessica Spence, Jean-Pierre Daurès, P. J. Devereaux, Paul Landais, Yannick Le Manach

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Association between postsurgical pain and heart rate variability: protocol for a scoping review by Michael McGillion, P J Devereaux, Ian Gilron, Gregory Klar, Vincent So, Jordan Leitch, Ramiro Arellano, Joel Parlow

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New‐Onset Perioperative Atrial Fibrillation After Coronary Artery Bypass Grafting and Long‐Term Risk of Adverse Events: An Analysis From the CORONARY Trial by David Conen, Michael K. Wang, P. J. Devereaux, Richard Whitlock, William F. McIntyre, Jeff S. Healey, Fei Yuan, Salim Yusuf, Andre Lamy

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Machine learning algorithms to identify cluster randomized trials from MEDLINE and EMBASE by Ahmed A. Al-Jaishi, Monica Taljaard, Melissa D. Al-Jaishi, Sheikh S. Abdullah, Lehana Thabane, P. J. Devereaux, Stephanie N. Dixon, Amit X. Garg

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The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. by Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gøtzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David Moher

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A pragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solutions in open fractures (Aqueous-PREP): statistical analysis plan by Nathan N. O’Hara, Diane Heels-Ansdell, Sofia Bzovsky, Shannon Dodds, Lehana Thabane, Mohit Bhandari, Gordon Guyatt, P. J. Devereaux, Gerard P. Slobogean, Sheila Sprague, on behalf of the PREP-IT Investigators

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Electronic Versus Traditional Data Collection: A Multicenter Randomized Controlled Perioperative Pain Trial by James S. Khan, Lindsay A. Jibb, Jason W. Busse, Ian Gilron, Stephen Choi, James E. Paul, Michael McGillion, Sean Mackey, D. Norman Buckley, Shun Fu Lee, P. J. Devereaux

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Cost Implications of Left Atrial Appendage Occlusion During Cardiac Surgery: A Cost Analysis of the LAAOS III Trial by Adam Eqbal, Wesley Tong, Andre Lamy, Emilie Belley‐Cote, Domenico Paparella, Alexander Bogachev‐Prokophiev, Alistair G. Royse, Wilko Reents, P. J. Devereaux, Katheryn Brady, Jessica Vincent, Stuart J. Connolly, Richard P. Whitlock

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Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol by Carly C. Barron, Manoj M. Lalu, Duncan J. Stewart, Dean Fergusson, Homer Yang, David Moher, Peter Liu, David Mazer, P. J. Devereaux, Lauralyn McIntyre, On Behalf of the Canadian Perioperative Anesthesia Clinical Trials Group

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Immune biomarkers predictive of respiratory viral infection in elderly nursing home residents. by Jennie Johnstone, Robin Parsons, Fernando Botelho, Jamie Millar, Shelly McNeil, Tamas Fulop, Janet McElhaney, Melissa K Andrew, Stephen D Walter, P J Devereaux, Mehrnoush Malekesmaeili, Ryan R Brinkman, James Mahony, Jonathan Bramson, Mark Loeb

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SUPERIOR SVG: no touch saphenous harvesting to improve patency following coronary bypass grafting (a multi-Centre randomized control trial, NCT01047449) by Saswata Deb, Steve K. Singh, Domingos de Souza, Michael W. A. Chu, Richard Whitlock, Steven R. Meyer, Subodh Verma, Anders Jeppsson, Ayman Al-Saleh, Katheryn Brady, Purnima Rao-Melacini, Emilie P. Belley-Cote, Derrick Y. Tam, P. J. Devereaux, Richard J. Novick, Stephen E. Fremes, on behalf of The SUPERIOR SVG Study Investigators

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MyTEMP: Statistical Analysis Plan of a Registry-Based, Cluster-Randomized Clinical Trial by Stephanie N. Dixon, Jessica M. Sontrop, Ahmed Al-Jaishi, Lauren Killin, Christopher W. McIntyre, Sierra Anderson, Amit Bagga, Derek Benjamin, Peter Blake, P. J. Devereaux, Eduard Iliescu, Arsh Jain, Charmaine E. Lok, Gihad Nesrallah, Matthew J. Oliver, Sanjay Pandeya, Manish M. Sood, Paul Tam, Ron Wald, Michael Walsh, Merrick Zwarenstein, Amit X. Garg

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Use of Anticoagulation Therapy in Patients With Perioperative Atrial Fibrillation After Cardiac Surgery: A Systematic Review and Meta-analysis by Michael Ke Wang, MD, Rachel Heo, BHSc, MD, Pascal Meyre, MD, PhD, Louis Park, Steffen Blum, MD, William F. McIntyre, MD, PhD, Emilie Belley-Côté, MD, PhD, Lauren Birchenough, BHSc, Kiven Vuong, Jeff S. Healey, MD, MSc, P.J. Devereaux, MD, PhD, André Lamy, MD, MHSc, David Conen, MD, MPH

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Steroids In caRdiac Surgery (SIRS) trial: acute kidney injury substudy protocol of an international randomised controlled trial by Michael Walsh, Salim Yusuf, Chirag Parikh, Jessica Vincent, P J Devereaux, Francois Lamontagne, Matthew T V Chan, Richard Whitlock, Meaghan Cuerden, Amit X Garg, Andre Lamy, Daniel I Sessler, Kevin Teoh, Ainslie Hildebrand, Yunxia Zuo, Pallav Shah, Seyed Hesameddin Abbasi, Mackenzie Quantz, Jean-Pierre Yared, Nicolas Noiseux, Georgios Tagarakis, Antoine Rochon, Janice Pogue, Abbas Salehiomran

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Prevention of persistent pain with lidocaine infusions in breast cancer surgery (PLAN): study protocol for a multicenter randomized controlled trial by James S. Khan, Ian Gilron, P. J. Devereaux, Hance Clarke, Nour Ayach, George Tomlinson, May Lynn Quan, Karim S. Ladha, Stephen Choi, Allana Munro, Richard Brull, David W. Lim, Sinziana Avramescu, Philippe Richebé, Nicole Hodgson, James Paul, Daniel I. McIsaac, Simone Derzi, Geoff L. Zbitnew, Alexandra M. Easson, Naveed T. Siddiqui, Sarah J. Miles, Keyvan Karkouti, PLAN Trial Investigators

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Association Between Perioperative Atrial Fibrillation and Long-term Risks of Stroke and Death in Noncardiac Surgery: Systematic Review and Meta-analysis by Jessica T. Huynh, MD, Jeff S. Healey, MD, Kevin J. Um, MD, Maria E. Vadakken, Anand S. Rai, BSc, David Conen, MD, Pascal Meyre, MD, Jawad H. Butt, MD, Hooman Kamel, MD, Seleman J. Reza, BSc, Stephanie T. Nguyen, HBSc, Zardasht Oqab, MD, P.J. Devereaux, MD, Kumar Balasubramanian, MSc, Alexander P. Benz, MD, Emilie P. Belley-Cote, MD, William F. McIntyre, MD

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