Disección aórtica aguda: diagnóstico y manejo inicial by Juan Pablo Umaña, Jaime Camacho

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Beyond checkpoint inhibition: PD-1 cis-targeting of an IL-2Rβγ-biased interleukin-2 variant as a novel approach to build on checkpoint inhibition by Laura Codarri Deak, Masao Hashimoto, Pablo Umaña, Christian Klein

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The tumor-targeted CD40 agonist CEA-CD40 promotes T cell priming via a dual mode of action by increasing antigen delivery to dendritic cells and enhancing their activation by Pedro J Romero, Pablo Umana, Christine Trumpfheller, Eva Sum, Moritz Rapp, Harald Dürr, Alekhya Mazumdar

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Hypothyroidism is a Risk Factor for Atrial Fibrillation after Coronary Artery Bypass Graft by Marisol Carreno Jaimes, Luis Alberto Arciniegas Torrado, Néstor Fernando Sandoval Reyes, Jaime Camacho Mackenzie, Juan Pablo Umana Mallarino

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Cross-linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFNγ/CXCL10-dependent peripheral T cell recruitment in humanized murine model. by Floriana Cremasco, Elena Menietti, Dario Speziale, Johannes Sam, Stefano Sammicheli, Marine Richard, Ahmet Varol, Christian Klein, Pablo Umana, Marina Bacac, Sara Colombetti, Mario Perro

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Heparin-induced DRESS syndrome in a paediatric patient and successful anaesthetic management in cardiovascular bypass surgery: case report by Laura Peña-Blanco, Laura Gutiérrez-Soriano, Félix Ramón Montes, Andrea Barragán-Méndez, Susana Beltrán-Villegas, Juan José López-Reyes, Carlos A. Villa-Hincapié, Juan Pablo Umaña

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CAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulins by Christian Jost, Diana Darowski, John Challier, Vesna Pulko, Lydia J Hanisch, Wei Xu, Ekkehard Mössner, Alexander Bujotzek, Stefan Klostermann, Pablo Umana, Roland E. Kontermann, Christian Klein

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863 Novel radioimmunotherapy for lung cancer: a tumor targeting approach by Pedro Romero, Sara Labiano, Christian Klein, Pablo Umana, Tania Wyss, Christine Trumpfheller, Marie-Catherine Vozenin, Céline Godfroid, Jackeline Romero, Vincent Roh, Laura Codarri Deak, Genrich V Tolstonog

Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of s... by Marion Subklewe, Christian Klein, Sebastian Kobold, Pablo Umana, Stefan Endres, Christian Jost, Mohamed-Reda Benmebarek, Anne Freimoser-Grundschober, Sophia Stock, Anna-Kristina Kluever, Diana Darowski, Kay-Gunnar Stubenrauch, Joerg Benz, Ekkehard Moessner

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Pharmacokinetics and Pharmacodynamics of T-Cell Bispecifics in the Tumour Interstitial Fluid by Miro Julian Eigenmann, Tine Veronica Karlsen, Marek Wagner, Olav Tenstad, Tina Weinzierl, Tanja Fauti, Hans Peter Grimm, Trude Skogstrand, Christian Klein, Johannes Sam, Pablo Umana, Marina Bacac, Helge Wiig, Antje-Christine Walz

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Combination of T-Cell Bispecific Antibodies With PD-L1 Checkpoint Inhibition Elicits Superior Anti-Tumor Activity by Johannes Sam, Sara Colombetti, Tanja Fauti, Andreas Roller, Marlene Biehl, Linda Fahrni, Valeria Nicolini, Mario Perro, Tapan Nayak, Esther Bommer, Anne Schoenle, Maria Karagianni, Marine Le Clech, Nathalie Steinhoff, Christian Klein, Pablo Umaña, Marina Bacac

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JAK and mTOR inhibitors prevent cytokine release while retaining T cell bispecific antibody in vivo efficacy by Christian Klein, Marina Bacac, Pablo Umana, Martin Stern, Gabrielle Leclercq, Hélène Haegel, Anneliese Schneider, Anna Maria Giusti, Vesna Pulko, Johannes Sam, John Challier, Alex Odermatt, Luke Green, Alberto Toso, Tina Zimmermann, Nathalie Steinhoff, Anne Freimoser-Grundschober, Laurent Larivière

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Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells by Reinhard Dummer, Marina Bacac, Pablo Umana, Mitchell P Levesque, Christine Trumpfheller, Mi He, Bhavesh Soni, Petra C Schwalie, Tamara Hüsser, Caroline Waltzinger, Duvini De Silva, Ylva Prinz, Laura Krümpelmann, Samuele Calabro, Ines Matos, Maries van den Broek, Stephan Gasser

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ROCKETS – a novel one-for-all toolbox for light sheet microscopy in drug discovery by Joerg P. J. Mueller, Joerg P. J. Mueller, Michael Dobosz, Nils O’Brien, Nassri Abdoush, Anna Maria Giusti, Martin Lechmann, Franz Osl, Ann-Katrin Wolf, Ann-Katrin Wolf, Estibaliz Arellano-Viera, Haroon Shaikh, Markus Sauer, Andreas Rosenwald, Frank Herting, Pablo Umaña, Sara Colombetti, Thomas Pöschinger, Andreas Beilhack

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Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody by Martina Geiger, Kay-Gunnar Stubenrauch, Johannes Sam, Wolfgang F. Richter, Gregor Jordan, Jan Eckmann, Carina Hage, Valeria Nicolini, Anne Freimoser-Grundschober, Mirko Ritter, Matthias E. Lauer, Henning Stahlberg, Philippe Ringler, Jigar Patel, Eric Sullivan, Sandra Grau-Richards, Stefan Endres, Sebastian Kobold, Pablo Umaña, Peter Brünker, Christian Klein

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The physiological interactome of TCR-like antibody therapeutics in human tissues by Estelle Marrer-Berger, Annalisa Nicastri, Angelique Augustin, Vesna Kramar, Hanqing Liao, Lydia Jasmin Hanisch, Alejandro Carpy, Tina Weinzierl, Evelyne Durr, Nathalie Schaub, Ramona Nudischer, Daniela Ortiz-Franyuti, Ekaterina Breous-Nystrom, Janick Stucki, Nina Hobi, Giulia Raggi, Lauriane Cabon, Emmanuelle Lezan, Pablo Umaña, Isaac Woodhouse, Alexander Bujotzek, Christian Klein, Nicola Ternette

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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

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Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune re... by Anna Spreafico, Eva Muñoz Couselo, Anja Irmisch, Juliana Bessa, George Au-Yeung, Oliver Bechter, Inge Marie Svane, Miguel F. Sanmamed, Miguel F. Sanmamed, Valentina Gambardella, Valentina Gambardella, Meredith McKean, Margaret Callahan, Reinhard Dummer, Christian Klein, Pablo Umaña, Nicole Justies, Florian Heil, Linda Fahrni, Eugenia Opolka-Hoffmann, Inja Waldhauer, Conrad Bleul, Roland F. Staack, Vaios Karanikas, Stephen Fowler

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P1211: TUMOR-ACTIVATED LYMPH NODE FIBROBLASTS SUPPRESS T CELL FUNCTION IN DIFFUSE LARGE B CELL LYMPHOMA by Benedetta Apollonio, Filomena Spada, Nedyalko Petrov, Domenico Cozzetto, Peter Jarvis, Despoina Papazoglou, Shichina Kannambath, Manuela Terranova-Barberio, Rose-Marie Amini, Gunilla Enblad, Charlotte Graham, Reuben Benjamin, Elizabeth H. Phillips, Richard Ellis, Rosamond Nuamah, Mansoor Saqi, Dinis Calado, Richard Rosenquist, Lesley Ann Sutton, Jon Salisbury, Georgios Zacharioudakis, Anna Vardi, Patrick Hagner, Anita Gandhi, Marina Bacac, Christina Claus, Pablo Umana, Ruth Jarrett, Christian Klein, Alexander Deutsch, Alan Ramsay

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Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma by Benedetta Apollonio, Filomena Spada, Nedyalko Petrov, Domenico Cozzetto, Despoina Papazoglou, Peter Jarvis, Shichina Kannambath, Manuela Terranova-Barberio, Rose-Marie Amini, Gunilla Enblad, Charlotte Graham, Reuben Benjamin, Elisabeth Phillips, Richard Ellis, Rosamond Nuamah, Mansoor Saqi, Dinis P. Calado, Richard Rosenquist, Lesley A. Sutton, Jon Salisbury, Georgios Zacharioudakis, Anna Vardi, Patrick R. Hagner, Anita K. Gandhi, Marina Bacac, Christina Claus, Pablo Umana, Ruth F. Jarrett, Christian Klein, Alexander Deutsch, Alan G. Ramsay

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