Germline variation in inflammation-related pathways and risk of Barrett’s esophagus and esophageal adenocarcinoma by Buas, M, He, Q, Johnson, L, Palles, C, Love, S, Tomlinson, I

A panoply of errors: polymerase proofreading domain mutations in cancer by Rayner, E, Van Gool, I, Palles, C, Kearsey, S, Bosse, T, Tomlinson, I, Church, D

'Toxgnostics': an unmet need in cancer medicine. by Church, D, Kerr, R, Domingo, E, Rosmarin, D, Palles, C, Maskell, K, Tomlinson, I, Kerr, D

'Toxgnostics': An unmet need in cancer medicine by Church, D, Kerr, R, Domingo, E, Rosmarin, D, Palles, C, Maskell, K, Tomlinson, I, Kerr, D

ToxNav germline genetic testing and PROMinet digital mobile application toxicity monitoring: Results of a prospective single-center clinical utility study-PRECISE study. by Lee, L, Starkey, T, Sivakumar, S, Fotheringham, S, Mozolowski, G, Shearwood, V, Palles, C, Camilleri, P, Church, D, Kerr, R, Kerr, D

Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer by Rodriguez-Broadbent, H, Law, P, Sud, A, Palles, C, Martin, L, Barclay, E, Maughan, T, Kerr, R, Kerr, D, Tomlinson, I

Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus by Su, Z, Gay, L, Strange, A, Palles, C, Palles, C, Band, G, Whiteman, D, Lescai, F, Langford, C, Nanji, M, Edkins, S, Van Der Winkel, A, Levine, D, Sasieni, P, Bellenguez, C, Howarth, K, Freeman, C, Trudgill, N, Tucker, A, Pirinen, M, Peppelenbosch, M, Van Der Laan, L, Kuipers, E, Drenth, J, Peters, W

Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication by Soriano, I, Vazquez, E, De Leon, N, Bertrand, S, Heitzer, E, Toumazou, S, Bo, Z, Palles, C, Pai, C-C, Humphrey, TC, Tomlinson, I, Cotterill, S, Kearsey, SE

DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer. by Church, D, Briggs, SE, Palles, C, Domingo, E, Kearsey, S, Grimes, J, Gorman, M, Martin, L, Howarth, K, Hodgson, S, NSECG Collaborators, Kaur, K, Taylor, J, Tomlinson, I

Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer. by Chubb, D, Broderick, P, Dobbins, SE, Frampton, M, Kinnersley, B, Penegar, S, Price, A, Ma, YP, Sherborne, AL, Palles, C, Timofeeva, MN, Bishop, DT, Dunlop, MG, Tomlinson, I, Houlston, RS

Large scale meta-analysis identifies new genetic risk loci for esophageal adenocarcinoma (EA) and the first EA risk locus independent of Barrett’s esophagus by Palles, C, Tomlinson, I, Chegwidden, L, Gharahkhani, P, MacGregor, S, Vaughan, T, Schumacher, J, Jankowski, J, Fitzgerald, R, Gockel, I, Buas, M, Knapp, M, Noethen, M, Becker, J, Pharaoh, P, Whiteman, D

The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression. by Thomas, R, Trapani, D, Goodyer-Sait, L, Tomkova, M, Fernandez-Rozadilla, C, Sahnane, N, Woolley, C, Davis, H, Chegwidden, L, Kriaucionis, S, Maughan, T, Leedham, S, Palles, C, Furlan, D, Tomlinson, I, Lewis, A

Germline de novo mutations in families with Mendelian cancer syndromes caused by defects in DNA repair by Sherwood, K, Ward, JC, Soriano, I, Martin, L, Campbell, A, Rahbari, R, Kafetzopoulos, I, Sproul, D, Green, A, Sampson, JR, Donaldson, A, Ong, K, Heinimann, K, Nielsen, M, Thomas, H, Latchford, A, Palles, C, Tomlinson, I

Detailed molecular and immune marker profiling of archival prostate cancer samples reveals an inverse association between TMPRSS2:ERG fusion status and immune cell infiltration by Rao, SR, Alham, NK, Upton, E, McIntyre, S, Bryant, RJ, Cerundolo, L, Bowes, E, Jones, S, Browne, M, Mills, I, Lamb, A, Tomlinson, I, Wedge, D, Browning, L, Sirinukunwattana, K, Palles, C, Hamdy, FC, Rittscher, J, Verrill, C

POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer by Klenerman, P, Church, D, Tomlinson, I, van Gool, I, Eggink, F, Freeman-Mills, L, Stelloo, E, Marchi, E, de Bruyn, M, Palles, C, Nout, R, de Kroon, C, Osse, E, Creutzberg, C, Smit, V, Nijman, H, Bosse, T

Re: Role of the oxidative DNA damage repair gene OGG1 in colorectal tumorigenesis. by Kinnersley, B, Buch, S, Castellví-Bel, S, Farrington, S, Forsti, A, Hampe, J, Hemminki, K, Hofstra, R, Northwood, E, Palles, C, Pinheiro, M, Ruiz-Ponte, C, Schafmayer, C, Teixeira, MR, Westers, H, Wezel, T, Bishop, D, Tomlinson, I, Dunlop, MG, Houlston, R

Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy by Findlay, J, Castro-Giner, F, Makino, S, Rayner, E, Kartsonaki, C, Cross, W, Kovac, M, Ulahannan, D, Palles, C, Gillies, R, MacGregor, T, Church, D, Maynard, N, Buffa, F, Cazier, J, Graham, T, Wang, L, Sharma, R, Middleton, M, Tomlinson, I

Deciphering the genetic architecture of low-penetrance susceptibility to colorectal cancer. by Whiffin, N, Dobbins, SE, Hosking, F, Palles, C, Tenesa, A, Wang, Y, Farrington, S, Jones, A, Broderick, P, Campbell, H, Newcomb, P, Casey, G, Conti, D, Schumacher, F, Gallinger, S, Lindor, N, Hopper, J, Jenkins, M, Dunlop, MG, Tomlinson, I, Houlston, R

Pattern recognition receptor polymorphisms as predictors of oxaliplatin benefit in colorectal cancer by Gray, V, Briggs, S, Palles, C, Jaeger, E, Iveson, T, Kerr, R, Saunders, M, Paul, J, Harkin, A, McQueen, J, Summers, M, Johnstone, E, Wang, H, Gatcombe, L, Maughan, T, Kaplan, R, Escott-Price, V, Al-Tassan, N, Meyer, B, Wakil, S, Houlston, R, Cheadle, J, Tomlinson, I, Church, D

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk by Dunlop, MG, Dobbins, SE, Farrington, S, Jones, A, Palles, C, Whiffin, N, Tenesa, A, Spain, S, Broderick, P, Ooi, L, Domingo, E, Smillie, C, Henrion, M, Frampton, M, Martin, L, Grimes, G, Gorman, M, Semple, C, Ma, Y, Barclay, E, Prendergast, J, Cazier, J, Olver, B, Penegar, S, Lubbe, S