Germline RUNX1 variants in paediatric patients in a French specialised centre by Cécile Liu, Paola Ballerini, Guillaume Nguyen, Zoia Mincheva, Bruno Copin, Boutheina Bouslama, Guy Leverger, Arnaud Petit, Rémi Favier, Hélène Lapillonne, Hélène Boutroux

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Efficient elimination of primary B-ALL cells in vitro and in vivo using a novel 4-1BB-based CAR targeting a membrane-distal CD22 epitope by Pablo Menendez, Pablo Engel, Clara Bueno, Matteo Libero Baroni, Talia Velasco-Hernandez, Heleia Roca-Ho, Francisco Gutierrez-Aguera, Paolo Petazzi, Diego Sánchez-Martínez, Oscar Molina, Paola Ballerini, Narcis Fernandez-Fuentes

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Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers by Aleksandra Georgievski, Pierre-Simon Bellaye, Benjamin Tournier, Hélène Choubley, Jean-Paul Pais de Barros, Michaële Herbst, Arnaud Béduneau, Patrick Callier, Bertrand Collin, Frédérique Végran, Paola Ballerini, Carmen Garrido, Ronan Quéré

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TIM3, a human acute myeloid leukemia stem cell marker, does not enrich for leukemia-initiating stem cells in B-cell acute lymphoblastic leukemia by Clara Bueno, Alba Martínez, Paola Alejandra Romecin, Samanta Romina Zanetti, Ricky Tirtakusuma, Eulalia Genesca, Mireia Camós, Manuel Ramírez-Orellana, Eduardo Anguita, Paola Ballerini, Franco Locatelli, José Luis Fuster, Pablo Menéndez

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Homeobox protein TLX3 activates miR-125b expression to promote T-cell acute lymphoblastic leukemia by Laurent Renou, Pierre-Yves Boelle, Caroline Deswarte, Salvatore Spicuglia, Aissa Benyoucef, Julien Calvo, Benjamin Uzan, Mohamed Belhocine, Agata Cieslak, Judith Landman-Parker, Andre Baruchel, Vahid Asnafi, Françoise Pflumio, Paola Ballerini, Irina Naguibneva

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HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias by Rony Mshaik, John Simonet, Aleksandra Georgievski, Layla Jamal, Shaliha Bechoua, Paola Ballerini, Pierre-Simon Bellaye, Zandile Mlamla, Jean-Paul Pais de Barros, Audrey Geissler, Pierre-Jean Francin, François Girodon, Carmen Garrido, Ronan Quéré

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Bone marrow sites differently imprint dormancy and chemoresistance to T-cell acute lymphoblastic leukemia by Xavier Cahu, Julien Calvo, Sandrine Poglio, Nais Prade, Benoit Colsch, Marie-Laure Arcangeli, Thierry Leblanc, Arnaud Petit, Frederic Baleydier, Andre Baruchel, Judith Landman-Parker, Christophe Junot, Jerome Larghero, Paola Ballerini, Eric Delabesse, Benjamin Uzan, Francoise Pflumio

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Impact of genotype on survival of children with T-cell acute lymphoblastic leukemia treated according to the French protocol FRALLE-93: the effect of TLX3/HOX11L2 gene expression o... by Paola Ballerini, Judith Landman-Parker, Jean Michel Cayuela, Vahid Asnafi, Myriam Labopin, Virginie Gandemer, Yves Perel, Gérard Michel, Thierry Leblanc, Claudine Schmitt, Sylvie Fasola, Anne Hagemejier, François Sigaux, Marie Françoise Auclerc, Luc Douay, Guy Leverger, André Baruchel

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Germline RUNX1 Intragenic Deletion: Implications for Accurate Diagnosis of FPD/AML by Nicolas Duployez, Jean-Edouard Martin, Sabine Khalife-Hachem, Ryane Benkhelil, Véronique Saada, Christophe Marzac, Nathalie Auger, Alice Marceau-Renaut, Rémi Favier, Paola Ballerini, Olivier Caron, André Baruchel, Stéphane de Botton, Claude Preudhomme, Jean-Baptiste Micol, Hana Raslova, Iléana Antony-Debré

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Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis by Antonio Agraz-Doblas, Clara Bueno, Rachael Bashford-Rogers, Anindita Roy, Pauline Schneider, Michela Bardini, Paola Ballerini, Gianni Cazzaniga, Thaidy Moreno, Carlos Revilla, Marta Gut, Maria G. Valsecchi, Irene Roberts, Rob Pieters, Paola De Lorenzo, Ignacio Varela, Pablo Menendez, Ronald W. Stam

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Interleukin‐18 produced by bone marrow‐derived stromal cells supports T‐cell acute leukaemia progression by Benjamin Uzan, Sandrine Poglio, Bastien Gerby, Ching‐Lien Wu, Julia Gross, Florence Armstrong, Julien Calvo, Xavier Cahu, Caroline Deswarte, Florent Dumont, Diana Passaro, Corinne Besnard‐Guérin, Thierry Leblanc, André Baruchel, Judith Landman‐Parker, Paola Ballerini, Véronique Baud, Jacques Ghysdael, Frédéric Baleydier, Francoise Porteu, Francoise Pflumio

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Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture by Simon Stritt, Paquita Nurden, Remi Favier, Marie Favier, Silvia Ferioli, Sanjeev K. Gotru, Judith M M. van Eeuwijk, Harald Schulze, Alan T. Nurden, Michele P. Lambert, Ernest Turro, Stephanie Burger-Stritt, Masayuki Matsushita, Lorenz Mittermeier, Paola Ballerini, Susanna Zierler, Michael A. Laffan, Vladimir Chubanov, Thomas Gudermann, Bernhard Nieswandt, Attila Braun

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Increased RhoA pathway activation downstream of αIIbβ3/SRC contributes to heterozygous Bernard Soulier syndrome by Larissa Lordier, Christian A. Di Buduo, Alexandre Kauskot, Nathalie Balayn, Cécile Lavenu-Bombled, Francesco Baschieri, Valérie Proulle, Cecilia P. Marin Oyarzun, Francesca Careddu, Ida Biunno, Tudor Manoliu, Philippe Rameau, Isabelle Plo, Nicolas Papadopoulos, Stefan Constantinescu, William Vainchenker, Guillaume Nam Nguyen, Paola Ballerini, Remi Favier, Alessandra Balduini, Hana Raslova

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Developmental interplay between transcriptional alterations and a targetable cytokine signaling dependency in pediatric ETO2::GLIS2 leukemia by Verónica Alonso-Pérez, Klaudia Galant, Fabien Boudia, Elie Robert, Zakia Aid, Laurent Renou, Vilma Barroca, Saryiami Devanand, Loélia Babin, Virginie Rouiller-Fabre, Delphine Moison, Didier Busso, Guillaume Piton, Christophe Metereau, Nassera Abermil, Paola Ballerini, Pierre Hirsch, Rima Haddad, Jelena Martinovic, Arnaud Petit, Hélène Lapillonne, Erika Brunet, Thomas Mercher, Françoise Pflumio

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Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high‐hyperdiploid B‐cell acute lymphoblastic leukemia by Mireia Ramos‐Muntada, Juan L. Trincado, Joan Blanco, Clara Bueno, Virginia C. Rodríguez‐Cortez, Alex Bataller, Belén López‐Millán, Claire Schwab, Margarita Ortega, Pablo Velasco, Maria L. Blanco, Josep Nomdedeu, Manuel Ramírez‐Orellana, Alfredo Minguela, Jose L. Fuster, Esther Cuatrecasas, Mireia Camós, Paola Ballerini, Gabriele Escherich, Judith Boer, Monique DenBoer, Jesús M. Hernández‐Rivas, Maria J. Calasanz, Giovanni Cazzaniga, Christine J. Harrison, Pablo Menéndez, Oscar Molina

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