Targeting Hedgehog Signalling through the Ubiquitylation Process: The Multiple Roles of the HECT-E3 Ligase Itch by Paola Infante, Ludovica Lospinoso Severini, Flavia Bernardi, Francesca Bufalieri, Lucia Di Marcotullio

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DUBs Activating the Hedgehog Signaling Pathway: A Promising Therapeutic Target in Cancer by Francesca Bufalieri, Ludovica Lospinoso Severini, Miriam Caimano, Paola Infante, Lucia Di Marcotullio

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Discovery, characterization and potential roles of a novel NF-YAx splice variant in human neuroblastoma by Lucia Cappabianca, Antonietta Rosella Farina, Lucia Di Marcotullio, Paola Infante, Daniele De Simone, Michela Sebastiano, Andrew Reay Mackay

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Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy. by Sonia Coni, Laura Antonucci, Davide D'Amico, Laura Di Magno, Paola Infante, Enrico De Smaele, Giuseppe Giannini, Lucia Di Marcotullio, Isabella Screpanti, Alberto Gulino, Gianluca Canettieri

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Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61 by Andrea Calcaterra, Valentina Iovine, Bruno Botta, Deborah Quaglio, Ilaria D’Acquarica, Alessia Ciogli, Antonia Iazzetti, Romina Alfonsi, Ludovica Lospinoso Severini, Paola Infante, Lucia Di Marcotullio, Mattia Mori, Francesca Ghirga

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The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I by Francesca Bufalieri, Miriam Caimano, Ludovica Lospinoso Severini, Irene Basili, Francesco Paglia, Luigi Sampirisi, Elena Loricchio, Marialaura Petroni, Gianluca Canettieri, Antonio Santoro, Luca D’Angelo, Paola Infante, Lucia Di Marcotullio

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A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth by Ludovica Lospinoso Severini, Deborah Quaglio, Irene Basili, Francesca Ghirga, Francesca Bufalieri, Miriam Caimano, Silvia Balducci, Marta Moretti, Isabella Romeo, Elena Loricchio, Marella Maroder, Bruno Botta, Mattia Mori, Paola Infante, Lucia Di Marcotullio

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Identification and Characterization of KCASH2 and KCASH3, 2 Novel Cullin3 Adaptors Suppressing Histone Deacetylase and Hedgehog Activity in Medulloblastoma by Enrico De Smaele, Lucia Di Marcotullio, Marta Moretti, Marianna Pelloni, Maria Anna Occhione, Paola Infante, Danilo Cucchi, Azzura Greco, Laura Pietrosanti, Jelena Todorovic, Sonia Coni, Gianluca Canettieri, Elisabetta Ferretti, Roberto Bei, Marella Maroder, Isabella Screpanti, Alberto Gulino

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β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells by Evelina Miele, Agnese Po, Federica Begalli, Laura Antonucci, Angela Mastronuzzi, Carlo Efisio Marras, Andrea Carai, Danilo Cucchi, Luana Abballe, Zein Mersini Besharat, Giuseppina Catanzaro, Paola Infante, Lucia Di Marcotullio, Gianluca Canettieri, Enrico De Smaele, Isabella Screpanti, Franco Locatelli, Elisabetta Ferretti

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Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation by Sonia Coni, Silvia Maria Serrao, Zuleyha Nihan Yurtsever, Laura Di Magno, Rosa Bordone, Camilla Bertani, Valerio Licursi, Zaira Ianniello, Paola Infante, Marta Moretti, Marialaura Petroni, Francesca Guerrieri, Alessandro Fatica, Alberto Macone, Enrico De Smaele, Lucia Di Marcotullio, Giuseppe Giannini, Marella Maroder, Enzo Agostinelli, Gianluca Canettieri

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Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma by Valeria Lucarini, Ombretta Melaiu, Silvia D’Amico, Fabio Pastorino, Patrizia Tempora, Marco Scarsella, Marco Pezzullo, Adele De Ninno, Valentina D’Oria, Michele Cilli, Laura Emionite, Paola Infante, Lucia Di Marcotullio, Maria Antonietta De Ioris, Giovanni Barillari, Rita Alaggio, Luca Businaro, Mirco Ponzoni, Franco Locatelli, Doriana Fruci

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1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma by Giuseppina D’Alessandro, Deborah Quaglio, Lucia Monaco, Clotilde Lauro, Francesca Ghirga, Cinzia Ingallina, Michela De Martino, Sergio Fucile, Alessandra Porzia, Maria Amalia Di Castro, Federica Bellato, Francesca Mastrotto, Mattia Mori, Paola Infante, Paola Turano, Stefano Salmaso, Paolo Caliceti, Lucia Di Marcotullio, Bruno Botta, Veronica Ghini, Cristina Limatola

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A Simplified Genomic Profiling Approach Predicts Outcome in Metastatic Colorectal Cancer by Carlo Capalbo, Francesca Belardinilli, Domenico Raimondo, Edoardo Milanetti, Umberto Malapelle, Pasquale Pisapia, Valentina Magri, Alessandra Prete, Silvia Pecorari, Mariarosaria Colella, Anna Coppa, Caterina Bonfiglio, Arianna Nicolussi, Virginia Valentini, Alessandra Tessitore, Beatrice Cardinali, Marialaura Petroni, Paola Infante, Matteo Santoni, Marco Filetti, Valeria Colicchia, Paola Paci, Silvia Mezi, Flavia Longo, Enrico Cortesi, Paolo Marchetti, Giancarlo Troncone, Diana Bellavia, Gianluca Canettieri, Giuseppe Giannini

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SMA-miRs (miR-181a-5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples by Emanuela Abiusi, Paola Infante, Cinzia Cagnoli, Ludovica Lospinoso Severini, Marika Pane, Giorgia Coratti, Maria Carmela Pera, Adele D'Amico, Federica Diano, Agnese Novelli, Serena Spartano, Stefania Fiori, Giovanni Baranello, Isabella Moroni, Marina Mora, Maria Barbara Pasanisi, Krizia Pocino, Loredana Le Pera, Davide D'Amico, Lorena Travaglini, Francesco Ria, Claudio Bruno, Denise Locatelli, Enrico Silvio Bertini, Lucia Ovidia Morandi, Eugenio Mercuri, Lucia Di Marcotullio, Francesco Danilo Tiziano

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