A population of in silico models to face the variability of human induced pluripotent stem cell-derived cardiomyocytes: the hERG block case study by Paci, M, Passini, E, Severi, S, Hyttinen, J, Rodriguez, B

Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: An in silico approach by Paci, M, Passini, E, Severi, S, Hyttinen, J, Rodriguez, B

Comparison of the simulated response of three in silico human stem cell-derived cardiomyocytes models and in vitro data under 15 drug actions by Paci, M, T Koivumäki, J, Lu, HR, Gallacher, DJ, Passini, E, Rodriguez, B

Drug‐induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias by Passini, E, Trovato, C, Morissette, P, Sannajust, F, Bueno-Orovio, A, Rodriguez, B

All-optical electrophysiology refines populations of in silico human iPSC-CMs for drug evaluation by Paci, M, Passini, E, Klimas, A, Severi, S, Hyttinen, J, Rodriguez, B, Entcheva, E

P511 In silico trials in human ventricular and purkinje cell models predict safety and efficacy of 10 antiarrhythmic drugs by Trovato, C, Passini, E, Tissier, A, Nagy, N, Varro', A, Severi, S, Rodriguez, B

The virtual assay software for human in silico drug trials to augment drug cardiac testing by Passini, E, Zhou, X, Trovato, C, Britton, OJ, Bueno-Orovio, A, Rodriguez, B

Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior by Varró, A, Tomek, J, Nagy, N, Virag, L, Passini, E, Rodriguez, B, Baczkó, I

Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy. by Passini, E, Mincholé, A, Coppini, R, Cerbai, E, Rodriguez, B, Severi, S, Bueno-Orovio, A

Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities by Trovato, C, Passini, E, Nagy, N, Varro, A, Abi-Gerges, N, Severi, S, Rodriguez, B

Blinded in silico drug trial reveals the minimum set of ion channels for torsades de pointes risk assessment by Zhou, X, Qu, Y, Passini, E, Bueno Orovio, A, Liu, Y, Vargas, H, Rodriguez, B

Human in silico drug trials demonstrate higher accuracy than animal models in predicting clinical pro-arrhythmic cardiotoxicity by Passini, E, Britton, O, Lu, H, Rohrbacher, J, Hermans, A, Gallacher, D, Greig, R, Bueno-Orovo, A, Rodriguez, B

Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm. by Muszkiewicz, A, Britton, O, Gemmell, P, Passini, E, Sánchez, C, Zhou, X, Carusi, A, Quinn, T, Burrage, K, Bueno-Orovio, A, Rodriguez, B

Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block by Tomek, J, Bueno-Orovio, A, Passini, E, Zhou, X, Minchole, A, Britton, O, Bartolucci, C, Severi, S, Shrier, A, Virag, L, Varro, A, Rodriguez, B

Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay by Morissette, P, Polak, S, Chain, A, Zhai, J, Imredy, JP, Wildey, MJ, Travis, J, Fitzgerald, K, Fanelli, P, Passini, E, Rodriguez, B, Sannajust, F, Regan, C

Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19 by Delaunois, A, Abernathy, M, Anderson, WD, Beattie, KA, Chaudhary, KW, Coulot, J, Gryshkova, V, Hebeisen, S, Holbrook, M, Kramer, J, Kuryshev, Y, Leishman, D, Lushbough, I, Passini, E, Redfern, WS, Rodriguez, B, Rossman, EI, Trovato, C, Wu, C, Valentin, J

General principles for the validation of proarrhythmia risk prediction models: an extension of the CiPA in silico strategy by Li, Z, Mirams, GR, Yoshinaga, T, Ridder, BJ, Han, X, Chen, JE, Stockbridge, NL, Wisialowski, TA, Damiano, B, Severi, S, Morissette, P, Kowey, PR, Holbrook, M, Smith, G, Rasmusson, RL, Liu, M, Song, Z, Qu, Z, Leishman, DJ, Steidl‐Nichols, J, Rodriguez, B, Bueno‐Orovio, A, Zhou, X, Passini, E, Edwards, AG

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial by Burton, R, Rodriguez, B, Britton, O, Cardone-Noott, L, Lyon, A, Minchole, A, Muszkiewicz, A, Passini, E, Zhou, X, Carusi, A, Abi-Gerges, N, Ariga, R, Bub, G, Carapella, V, Daniels, M, Davies, M, Ghetti, A, Grau, V, Harmer, S, Koplar, I, Lambiase, P, Lu, H, Oster, J, Paci, M, Severi, S, Taggart, P, Tinker, A, Valentin, J, Varro, A, Wallman, M

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop by Burton, R, Rodriguez, B, Carusi, A, Abi-Gerges, N, Britton, O, Ariga, R, Bub, G, Bueno-Orovio, A, Carapella, V, Cardone-Noott, L, Daniels, M, Davies, M, Dutta, S, Ghetti, A, Grau, V, Harmer, S, Ivan, K, Pier, L, Lu, H, Lyon, A, Minchole, A, Muszkiewicz, A, Oster, J, Paci, M, Passini, E, Severi, S, Taggart, P, Tinker, A, valentin, J, Varro, A, Wallman, M, Zhou, X