Gene knock-outs in human CD34+ hematopoietic stem and progenitor cells and in the human immune system of mice. by Daniel A Kuppers, Jonathan Linton, Sergio Ortiz Espinosa, Kelly M McKenna, Anthony Rongvaux, Patrick J Paddison

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A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency. by Emily Hsieh, Derek H Janssens, Patrick J Paddison, Edward P Browne, Steve Henikoff, Molly OhAinle, Michael Emerman

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Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones by Jay F Sarthy, Michael P Meers, Derek H Janssens, Jorja G Henikoff, Heather Feldman, Patrick J Paddison, Christina M Lockwood, Nicholas A Vitanza, James M Olson, Kami Ahmad, Steven Henikoff

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Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3′ untranslated region mutations by Samantha L. Schuster, Sonali Arora, Cynthia L. Wladyka, Pushpa Itagi, Lukas Corey, Dave Young, Bethany L. Stackhouse, Lori Kollath, Qian V. Wu, Eva Corey, Lawrence D. True, Gavin Ha, Patrick J. Paddison, Andrew C. Hsieh

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Neural G0: a quiescent‐like state found in neuroepithelial‐derived cells and glioma by Samantha A O’Connor, Heather M Feldman, Sonali Arora, Pia Hoellerbauer, Chad M Toledo, Philip Corrin, Lucas Carter, Megan Kufeld, Hamid Bolouri, Ryan Basom, Jeffrey Delrow, José L McFaline‐Figueroa, Cole Trapnell, Steven M Pollard, Anoop Patel, Patrick J Paddison, Christopher L Plaisier

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A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1. by Davide Danovi, Amos Folarin, Sabine Gogolok, Christine Ender, Ahmed M O Elbatsh, Pär G Engström, Stefan H Stricker, Sladjana Gagrica, Ana Georgian, Ding Yu, Kin Pong U, Kevin J Harvey, Patrizia Ferretti, Patrick J Paddison, Jane E Preston, N Joan Abbott, Paul Bertone, Austin Smith, Steven M Pollard

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361 WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma by Christopher Hubert, Kelly Mitchell, Samuel Sprowls, Sajina Shakya, Sonali Arora, Daniel J. Silver, Christopher M. Goins, Lisa Wallace, Gustavo Roversi, Rachel Schafer, Kristen Kay, Tyler E. Miller, Adam Lauko, John Bassett, Anjali Kashyap, J. D’Amato Kass, Erin E. Mulkearns-Hubert, Sadie Johnson, Joseph Alvarado, Jeremy N. Rich, Patrick J. Paddison, Anoop P. Patel, Shaun R. Stauffer, Christopher G. Hubert, Justin D. Lathia

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Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells by Chad M. Toledo, Yu Ding, Pia Hoellerbauer, Ryan J. Davis, Ryan Basom, Emily J. Girard, Eunjee Lee, Philip Corrin, Traver Hart, Hamid Bolouri, Jerry Davison, Qing Zhang, Justin Hardcastle, Bruce J. Aronow, Christopher L. Plaisier, Nitin S. Baliga, Jason Moffat, Qi Lin, Xiao-Nan Li, Do-Hyun Nam, Jeongwu Lee, Steven M. Pollard, Jun Zhu, Jeffery J. Delrow, Bruce E. Clurman, James M. Olson, Patrick J. Paddison

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