Wisdom of the CROUD:  Development and validation of a patient-level prediction model for opioid use disorder using population-level claims data. by Jenna Marie Reps, M Soledad Cepeda, Patrick B Ryan

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Inferring disease severity in rheumatoid arthritis using predictive modeling in administrative claims databases. by Urmila Chandran, Jenna Reps, Paul E Stang, Patrick B Ryan

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Characterizing Anchoring Bias in Vaccine Comparator Selection Due to Health Care Utilization With COVID-19 and Influenza: Observational Cohort Study by Anna Ostropolets, Patrick B Ryan, Martijn J Schuemie, George Hripcsak

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Design matters in patient-level prediction: evaluation of a cohort vs. case-control design when developing predictive models in observational healthcare datasets by Jenna M. Reps, Patrick B. Ryan, Peter R. Rijnbeek, Martijn J. Schuemie

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Learning patient-level prediction models across multiple healthcare databases: evaluation of ensembles for increasing model transportability by Jenna Marie Reps, Ross D. Williams, Martijn J. Schuemie, Patrick B. Ryan, Peter R. Rijnbeek

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Development and evaluation of an algorithm to link mothers and infants in two US commercial healthcare claims databases for pharmacoepidemiology research by James Weaver, Jill H. Hardin, Clair Blacketer, Alexis A. Krumme, Melanie H. Jacobson, Patrick B. Ryan

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A standardized framework for risk-based assessment of treatment effect heterogeneity in observational healthcare databases by Alexandros Rekkas, David van Klaveren, Patrick B. Ryan, Ewout W. Steyerberg, David M. Kent, Peter R. Rijnbeek

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Medications for attention‐deficit/hyperactivity disorder in Japan: A retrospective cohort study of label compliance by Daniel Fife, Erica A. Voss, Jill Hardin, Hany Rofael, Ira D. Solomon, Patrick B. Ryan, Paul Stang

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Factors Influencing Background Incidence Rate Calculation: Systematic Empirical Evaluation Across an International Network of Observational Databases by Anna Ostropolets, Xintong Li, Rupa Makadia, Gowtham Rao, Peter R. Rijnbeek, Talita Duarte-Salles, Anthony G. Sena, Anthony G. Sena, Azza Shaoibi, Marc A. Suchard, Marc A. Suchard, Patrick B. Ryan, Patrick B. Ryan, Daniel Prieto-Alhambra, George Hripcsak, George Hripcsak

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Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world compar... by Rohan Khera, Yuan Lu, Harlan M Krumholz, Martijn J Schuemie, Ruijun Chen, George Hripcsak, Marc A Suchard, Patrick B Ryan, Anna Ostropolets

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An efficient and accurate distributed learning algorithm for modeling multi-site zero-inflated count outcomes by Mackenzie J. Edmondson, Chongliang Luo, Rui Duan, Mitchell Maltenfort, Zhaoyi Chen, Kenneth Locke, Justine Shults, Jiang Bian, Patrick B. Ryan, Christopher B. Forrest, Yong Chen

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Feasibility and evaluation of a large-scale external validation approach for patient-level prediction in an international data network: validation of models predicting stroke in fe... by Jenna M. Reps, Ross D. Williams, Seng Chan You, Thomas Falconer, Evan Minty, Alison Callahan, Patrick B. Ryan, Rae Woong Park, Hong-Seok Lim, Peter Rijnbeek

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Comparative safety and effectiveness of alendronate versus raloxifene in women with osteoporosis by Yeesuk Kim, Yuxi Tian, Jianxiao Yang, Vojtech Huser, Peng Jin, Christophe G. Lambert, Hojun Park, Seng Chan You, Rae Woong Park, Peter R. Rijnbeek, Mui Van Zandt, Christian Reich, Rohit Vashisht, Yonghui Wu, Jon Duke, George Hripcsak, David Madigan, Nigam H. Shah, Patrick B. Ryan, Martijn J. Schuemie, Marc A. Suchard

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Development and validation of a prognostic model predicting symptomatic hemorrhagic transformation in acute ischemic stroke at scale in the OHDSI network. by Qiong Wang, Jenna M Reps, Kristin Feeney Kostka, Patrick B Ryan, Yuhui Zou, Erica A Voss, Peter R Rijnbeek, RuiJun Chen, Gowtham A Rao, Henry Morgan Stewart, Andrew E Williams, Ross D Williams, Mui Van Zandt, Thomas Falconer, Margarita Fernandez-Chas, Rohit Vashisht, Stephen R Pfohl, Nigam H Shah, Suranga N Kasthurirathne, Seng Chan You, Qing Jiang, Christian Reich, Yi Zhou

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DLMM as a lossless one-shot algorithm for collaborative multi-site distributed linear mixed models by Chongliang Luo, Md. Nazmul Islam, Natalie E. Sheils, John Buresh, Jenna Reps, Martijn J. Schuemie, Patrick B. Ryan, Mackenzie Edmondson, Rui Duan, Jiayi Tong, Arielle Marks-Anglin, Jiang Bian, Zhaoyi Chen, Talita Duarte-Salles, Sergio Fernández-Bertolín, Thomas Falconer, Chungsoo Kim, Rae Woong Park, Stephen R. Pfohl, Nigam H. Shah, Andrew E. Williams, Hua Xu, Yujia Zhou, Ebbing Lautenbach, Jalpa A. Doshi, Rachel M. Werner, David A. Asch, Yong Chen

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An open source knowledge graph ecosystem for the life sciences by Tiffany J. Callahan, Ignacio J. Tripodi, Adrianne L. Stefanski, Luca Cappelletti, Sanya B. Taneja, Jordan M. Wyrwa, Elena Casiraghi, Nicolas A. Matentzoglu, Justin Reese, Jonathan C. Silverstein, Charles Tapley Hoyt, Richard D. Boyce, Scott A. Malec, Deepak R. Unni, Marcin P. Joachimiak, Peter N. Robinson, Christopher J. Mungall, Emanuele Cavalleri, Tommaso Fontana, Giorgio Valentini, Marco Mesiti, Lucas A. Gillenwater, Brook Santangelo, Nicole A. Vasilevsky, Robert Hoehndorf, Tellen D. Bennett, Patrick B. Ryan, George Hripcsak, Michael G. Kahn, Michael Bada, William A. Baumgartner, Lawrence E. Hunter

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Ontologizing health systems data at scale: making translational discovery a reality by Tiffany J. Callahan, Adrianne L. Stefanski, Jordan M. Wyrwa, Chenjie Zeng, Anna Ostropolets, Juan M. Banda, William A. Baumgartner, Richard D. Boyce, Elena Casiraghi, Ben D. Coleman, Janine H. Collins, Sara J. Deakyne Davies, James A. Feinstein, Asiyah Y. Lin, Blake Martin, Nicolas A. Matentzoglu, Daniella Meeker, Justin Reese, Jessica Sinclair, Sanya B. Taneja, Katy E. Trinkley, Nicole A. Vasilevsky, Andrew E. Williams, Xingmin A. Zhang, Joshua C. Denny, Patrick B. Ryan, George Hripcsak, Tellen D. Bennett, Melissa A. Haendel, Peter N. Robinson, Lawrence E. Hunter, Michael G. Kahn

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International cohort study indicates no association between alpha-1 blockers and susceptibility to COVID-19 in benign prostatic hyperplasia patients by Akihiko Nishimura, Junqing Xie, Kristin Kostka, Kristin Kostka, Talita Duarte-Salles, Sergio Fernández Bertolín, María Aragón, Clair Blacketer, Azza Shoaibi, Scott L. DuVall, Scott L. DuVall, Kristine Lynch, Kristine Lynch, Michael E. Matheny, Michael E. Matheny, Thomas Falconer, Daniel R. Morales, Daniel R. Morales, Mitchell M. Conover, Seng Chan You, Nicole Pratt, James Weaver, Anthony G. Sena, Anthony G. Sena, Martijn J. Schuemie, Martijn J. Schuemie, Jenna Reps, Christian Reich, Peter R. Rijnbeek, Patrick B. Ryan, George Hripcsak, Daniel Prieto-Alhambra, Marc A. Suchard, Marc A. Suchard, Marc A. Suchard

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Contextualising adverse events of special interest to characterise the baseline incidence rates in 24 million patients with COVID-19 across 26 databases: a multinational retrospect... by Erica A. Voss, Azza Shoaibi, Lana Yin Hui Lai, Clair Blacketer, Thamir Alshammari, Rupa Makadia, Kevin Haynes, Anthony G. Sena, Gowtham Rao, Sebastiaan van Sandijk, Clement Fraboulet, Laurent Boyer, Tanguy Le Carrour, Scott Horban, Daniel R. Morales, Jordi Martínez Roldán, Juan Manuel Ramírez-Anguita, Miguel A. Mayer, Marcel de Wilde, Luis H. John, Talita Duarte-Salles, Elena Roel, Andrea Pistillo, Raivo Kolde, Filip Maljković, Spiros Denaxas, Vaclav Papez, Michael G. Kahn, Karthik Natarajan, Christian Reich, Alex Secora, Evan P. Minty, Nigam H. Shah, Jose D. Posada, Maria Teresa Garcia Morales, Diego Bosca, Honorio Cadenas Juanino, Antonio Diaz Holgado, Miguel Pedrera Jiménez, Pablo Serrano Balazote, Noelia García Barrio, Selçuk Şen, Ali Yağız Üresin, Baris Erdogan, Luc Belmans, Geert Byttebier, Manu L.N.G. Malbrain, Daniel J. Dedman, Zara Cuccu, Rohit Vashisht, Atul J. Butte, Ayan Patel, Lisa Dahm, Cora Han, Fan Bu, Faaizah Arshad, Anna Ostropolets, Fredrik Nyberg, George Hripcsak, Marc A. Suchard, Dani Prieto-Alhambra, Peter R. Rijnbeek, Martijn J. Schuemie, Patrick B. Ryan

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