Preface by Enrico Garaci, Patrizia Popoli

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Early access programs for medicines: a reform proposal for the Italian National Health Service by Patrizia Popoli, Giovanni Giuliani, Arturo Cavaliere, Claudio Jommi

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The role of the Istituto Superiore di Sanità as the competent authority for Phase I trials in the translation of advanced therapies by Patrizia Popoli, Maria Francesca Cometa, Fulvia Fabi, Annarita Meneguz

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Role of Adenosine A2A Receptors in Modulating Synaptic Functions and Brain Levels of BDNF: a Possible Key Mechanism in the Pathophysiology of Huntington's Disease by Maria Teresa Tebano, Alberto Martire, Valentina Chiodi, Antonella Ferrante, Patrizia Popoli

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Insight into the Role of the STriatal-Enriched Protein Tyrosine Phosphatase (STEP) in A2A Receptor-Mediated Effects in the Central Nervous System by Maria Rosaria Domenici, Cinzia Mallozzi, Rita Pepponi, Ida Casella, Valentina Chiodi, Antonella Ferrante, Patrizia Popoli

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Functional Interaction between Adenosine A_2A and mGlu₅ Receptors Mediates STEP Phosphatase Activation and Promotes STEP/mGlu₅R Binding in Mouse Hip... by Cinzia Mallozzi, Rita Pepponi, Lucia Gaddini, Ida Casella, Valentina Chiodi, Patrizia Popoli, Maria Rosaria Domenici

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Remodeling of striatal NMDA receptors by chronic A2A receptor blockade in Huntington's disease mice by Alberto Martire, Antonella Ferrante, Rosa Luisa Potenza, Monica Armida, Roberta Ferretti, Antonella Pézzola, Maria Rosaria Domenici, Patrizia Popoli

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The adenosine A2A receptor agonist T1–11 ameliorates neurovisceral symptoms and extends the lifespan of a mouse model of Niemann-Pick type C disease by Antonella Ferrante, Antonella Pezzola, Andrea Matteucci, Antonella Di Biase, Lucilla Attorri, Monica Armida, Alberto Martire, Yijuang Chern, Patrizia Popoli

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Expression, pharmacology and functional activity of adenosine A1 receptors in genetic models of Huntington's disease by Antonella Ferrante, Alberto Martire, Rita Pepponi, Katia Varani, Fabrizio Vincenzi, Luca Ferraro, Sarah Beggiato, Maria Teresa Tebano, Patrizia Popoli

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Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis by Savina Apolloni, Susanna Amadio, Chiara Parisi, Alessandra Matteucci, Rosa L. Potenza, Monica Armida, Patrizia Popoli, Nadia D’Ambrosi, Cinzia Volonté

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Adenosine Receptor Heteromers and their Integrative Role in Striatal Function by Sergi Ferré, Francisco Ciruela, César Quiroz, Rafael Luján, Patrizia Popoli, Rodrigo A. Cunha, Luigi F. Agnati, Kjell Fuxe, Amina S. Woods, Carme Lluis, Rafael Franco

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Towards a European harmonization of health technology assessment recommendations executive paper of European regulatory conference focused on the EU commission proposal to harmoniz... by Lucia Gozzo, Kenneth Paterson, Olivier Wong, Francis Megerlin, Jan Geldmacher, Patrizia Popoli, Claudio Jommi, Frank-Ulrich Fricke, Oriol De Solà-Morales, Isao Kamae, Guido Rasi, Filippo Drago, Filippo Drago, Filippo Drago

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Drugs price and reimbursement regulation: comparators, endpoints and role of the cost-effectiveness by Claudio Jommi, Giovanni Apolone, Giovanna Scroccaro, Valentina Acciai, Antonio Addis, Andrea Ardizzoni, Renato Bernardini, Alberto Bortolami, Alessia Brigido, Giuliano Buzzetti, Pier Luigi Canonico, Francesca Caprari, Stefano Centanni, Chiara Cernetti, Americo Cicchetti, Giorgio Corsico, Francesco Damele, Filippo De Braud, Sara Manurita, Francesco Saverio Mennini, Irene Olivi, Federica Parretta, Lara Pippo, Stefania Pulimeno, Massimo Riccaboni, Giuseppe Rossi, Cecilia Saleri, Alessandra Sinibaldi, Federico Spandonaro, Cristian Stefenoni, Elena Visentin, Pierluigi Viale, Giuseppina Zapparelli, Patrizia Popoli

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