65 PD-L1 by RNA next generation sequencing: comparison with PD-L1 IHC 22C3 and association with survival benefit from pembrolizumab with or without chemotherapy in non-small cell l... by Sarabjot Pabla, Mary Nesline, Paul DePietro, Jeffrey Conroy, Yong Hee Lee, Grace Dy

High CTLA-4 transcriptomic expression correlates with high expression of other checkpoints and with immunotherapy outcome by Nithya Krishnamurthy, Daisuke Nishizaki, Scott M. Lippman, Hirotaka Miyashita, Mary K. Nesline, Sarabjot Pabla, Jeffrey M. Conroy, Paul DePietro, Shumei Kato, Razelle Kurzrock

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166 High CTLA-4 transcriptomic expression correlates with high expression of other checkpoints and with outcome on immune checkpoint inhibitors by Razelle Kurzrock, Sarabjot Pabla, Shumei Kato, Nithya Krishnamurthy, Paul DePietro, Mary K Nesline, Jeffrey M Conroy, Daisuke Nishizaki, Scott M Lippman, Hirotaka Miyashita

High indoleamine 2,3-dioxygenase transcript levels predict better outcome after front-line cancer immunotherapy by Yu Fujiwara, Shumei Kato, Daisuke Nishizaki, Hirotaka Miyashita, Suzanna Lee, Mary K. Nesline, Jeffrey M. Conroy, Paul DePietro, Sarabjot Pabla, Scott M. Lippman, Razelle Kurzrock

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LAG‐3 transcriptomic expression patterns across malignancies: Implications for precision immunotherapeutics by Jacob J. Adashek, Shumei Kato, Daisuke Nishizaki, Hirotaka Miyashita, Pradip De, Suzanna Lee, Sarabjot Pabla, Mary Nesline, Jeffrey M. Conroy, Paul DePietro, Scott Lippman, Razelle Kurzrock

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4‐1BB transcriptomic expression patterns across malignancies: Implications for clinical trials of 4‐1BB agonists by Yuji Uehara, Shumei Kato, Daisuke Nishizaki, Hirotaka Miyashita, Suzanna Lee, Mary K. Nesline, Sarabjot Pabla, Jeffrey M. Conroy, Paul DePietro, Heidi Ko, Jason K. Sicklick, Razelle Kurzrock

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Pan‐cancer analysis of TIM‐3 transcriptomic expression reveals high levels in pancreatic cancer and interpatient heterogeneity by Jungah Lim, Razelle Kurzrock, Daisuke Nishizaki, Hirotaka Miyashita, Jacob J. Adashek, Suzanna Lee, Sarabjot Pabla, Mary Nesline, Jeffrey M. Conroy, Paul DePietro, Scott M. Lippman, Shumei Kato

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77 Prevalence of secondary immunotherapeutic targets in the absence of established immune biomarkers in solid tumors by Sean Glenn, Blake Burgher, Sarabjot Pabla, Vincent Giamo, RJ Seager, Erik Van Roey, Shuang Gao, Mary Nesline, Paul DePietro, Shengle Zhang, Jeffrey Conroy, Yong Hee Lee, Roger Klein

T-cell priming transcriptomic markers: implications of immunome heterogeneity for precision immunotherapy by Hirotaka Miyashita, Razelle Kurzrock, Nicholas J. Bevins, Kartheeswaran Thangathurai, Suzanna Lee, Sarabjot Pabla, Mary Nesline, Sean T. Glenn, Jeffrey M. Conroy, Paul DePietro, Eitan Rubin, Jason K. Sicklick, Shumei Kato

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70 Novel immunotherapeutic targets in cancer of unknown primary (CUP) by Sean Glenn, Blake Burgher, Sarabjot Pabla, Vincent Giamo, RJ Seager, Erik Van Roey, Shuang Gao, Mary Nesline, Paul DePietro, Shengle Zhang, Jeffrey Conroy, Yong Hee Lee, Zachery Bliss, Roger Klein

O09: Potential germline variants are frequently identified when performing comprehensive genomic profiling of solid tumors* by Taylor Jensen, Dagny Noeth, Amy Cronister, Paul DePietro, Roger Klein, Mary Nesline, Sarabjot Pabla, Anjen Chenn, Shengle Zhang, Jonathan Klein, Sarah Howarth, Eric Severson, Shakti Ramkissoon, Marcia Eisenberg, Prasanth Reddy, Jeffrey Conroy

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Integration of tumor inflammation, cell proliferation, and traditional biomarkers improves prediction of immunotherapy resistance and response by Sarabjot Pabla, R. J. Seager, Erik Van Roey, Shuang Gao, Carrie Hoefer, Mary K. Nesline, Paul DePietro, Blake Burgher, Jonathan Andreas, Vincent Giamo, Yirong Wang, Felicia L. Lenzo, Margot Schoenborn, Shengle Zhang, Roger Klein, Sean T. Glenn, Jeffrey M. Conroy

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The Impact of Prior Single-Gene Testing on Comprehensive Genomic Profiling Results for Patients with Non-Small Cell Lung Cancer by Mary K. Nesline, Vivek Subbiah, Rebecca A. Previs, Kyle C. Strickland, Heidi Ko, Paul DePietro, Michael D. Biorn, Maureen Cooper, Nini Wu, Jeffrey Conroy, Sarabjot Pabla, Shengle Zhang, Zachary D. Wallen, Pratheesh Sathyan, Kamal Saini, Marcia Eisenberg, Brian Caveney, Eric A. Severson, Shakti Ramkissoon

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Cancer testis antigen burden (CTAB): a novel biomarker of tumor-associated antigens in lung cancer by R. J. Seager, Maria-Fernanda Senosain, Erik Van Roey, Shuang Gao, Paul DePietro, Mary K. Nesline, Durga Prasad Dash, Shengle Zhang, Heidi Ko, Stephanie B. Hastings, Kyle C. Strickland, Rebecca A. Previs, Taylor J. Jensen, Marcia Eisenberg, Brian J. Caveney, Eric A. Severson, Shakti Ramkissoon, Jeffrey M. Conroy, Sarabjot Pabla

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Treatment recommendations to cancer patients in the context of FDA guidance for next generation sequencing by Grace K. Dy, Mary K. Nesline, Antonios Papanicolau-Sengos, Paul DePietro, Charles M. LeVea, Amy Early, Hongbin Chen, Anne Grand’Maison, Patrick Boland, Marc S. Ernstoff, Stephen Edge, Stacey Akers, Mateusz Opyrchal, Gurkamal Chatta, Kunle Odunsi, Sarabjot Pabla, Jeffrey M. Conroy, Sean T. Glenn, Hanchun T. DeFedericis, Blake Burgher, Jonathan Andreas, Vincent Giamo, Maochun Qin, Yirong Wang, Kazunori Kanehira, Felicia L. Lenzo, Peter Frederick, Shashikant Lele, Lorenzo Galluzzi, Boris Kuvshinoff, Carl Morrison

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