Advances in CAR T cell immunotherapy for paediatric brain tumours by Padmashree Rao, Liam Furst, Liam Furst, Deborah Meyran, Deborah Meyran, Deborah Meyran, Deborah Meyran, Chelsea Mayoh, Chelsea Mayoh, Paul J. Neeson, Paul J. Neeson, Rachael Terry, Rachael Terry, Dong-Anh Khuong-Quang, Dong-Anh Khuong-Quang, Dong-Anh Khuong-Quang, Theo Mantamadiotis, Theo Mantamadiotis, Paul G. Ekert, Paul G. Ekert, Paul G. Ekert, Paul G. Ekert, Paul G. Ekert, Paul G. Ekert

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MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data by Marek Cmero, Breon Schmidt, Ian J. Majewski, Paul G. Ekert, Alicia Oshlack, Nadia M. Davidson

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JAFFAL: detecting fusion genes with long-read transcriptome sequencing by Nadia M. Davidson, Ying Chen, Teresa Sadras, Georgina L. Ryland, Piers Blombery, Paul G. Ekert, Jonathan Göke, Alicia Oshlack

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In vivo loss of tumorigenicity in a patient-derived orthotopic xenograft mouse model of ependymoma by Jacqueline P. Whitehouse, Jacqueline P. Whitehouse, Hilary Hii, Chelsea Mayoh, Chelsea Mayoh, Marie Wong, Marie Wong, Pamela Ajuyah, Paulette Barahona, Louise Cui, Hetal Dholaria, Hetal Dholaria, Hetal Dholaria, Christine L. White, Christine L. White, Christine L. White, Molly K. Buntine, Molly K. Buntine, Jacob Byrne, Keteryne Rodrigues da Silva, Keteryne Rodrigues da Silva, Meegan Howlett, Meegan Howlett, Emily J. Girard, Emily J. Girard, Maria Tsoli, Maria Tsoli, David S. Ziegler, David S. Ziegler, David S. Ziegler, Jason M. Dyke, Jason M. Dyke, Sharon Lee, Paul G. Ekert, Paul G. Ekert, Paul G. Ekert, Paul G. Ekert, Paul G. Ekert, Mark J. Cowley, Mark J. Cowley, Nicholas G. Gottardo, Nicholas G. Gottardo, Nicholas G. Gottardo, Raelene Endersby, Raelene Endersby

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p53-Dependent transcriptional responses to interleukin-3 signaling. by Anissa M Jabbour, Lavinia Gordon, Carmel P Daunt, Benjamin D Green, Chung H Kok, Richard D'Andrea, Paul G Ekert

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Enhancing the Potential of Immunotherapy in Paediatric Sarcomas: Breaking the Immunosuppressive Barrier with Receptor Tyrosine Kinase Inhibitors by Emmy D. G. Fleuren, Rachael L. Terry, Deborah Meyran, Natacha Omer, Joseph A. Trapani, Michelle Haber, Paul J. Neeson, Paul G. Ekert

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Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis by Neevika Manoharan, Pamela Ajuyah, Akanksha Senapati, Marie Wong, Anna Mullins, Michael Rodriguez, Helen Doyle, Geoff McCowage, Loretta M. S. Lau, Paul G. Ekert, David S. Ziegler

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High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression by Nicole L. Wittwer, Gabriela Brumatti, Ceilidh Marchant, Jarrod J. Sandow, Melanie K. Pudney, Mara Dottore, Richard J. D'Andrea, Angel F. Lopez, Paul G. Ekert, Hayley S. Ramshaw

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Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins. by Katharine J Goodall, Megan L Finch-Edmondson, Joanne van Vuuren, George C Yeoh, Ian E Gentle, James E Vince, Paul G Ekert, David L Vaux, Bernard A Callus

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Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors. by Elizabeth M Algar, Andrea Muscat, Vinod Dagar, Christian Rickert, C W Chow, Jaclyn A Biegel, Paul G Ekert, Richard Saffery, Jeff Craig, Ricky W Johnstone, David M Ashley

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Monolysocardiolipins accumulate in Barth syndrome but do not lead to enhanced apoptosis by Fredoen Valianpour, Voula Mitsakos, Dimitri Schlemmer, Jeffrey A. Towbin, Juliet M. Taylor, Paul G. Ekert, David R. Thorburn, Arnold Munnich, Ronald J.A. Wanders, Peter G. Barth, Frédéric M. Vaz

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Novel paediatric case of a spinal high-grade astrocytoma with piloid features in a patient with Noonan Syndrome by Jordan Staunton, Pamela Ajuyah, Angela Harris, Chelsea Mayoh, Marie Wong, Megan Rumford, Patricia J. Sullivan, Paul G. Ekert, Noemi Fuentes-Bolanos, Mark J. Cowley, Loretta M. S. Lau, David S. Ziegler, Paulette Barahona, Neevika Manoharan

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Efficacy of MEK inhibition in a recurrent malignant peripheral nerve sheath tumor by Sumanth Nagabushan, Loretta M. S. Lau, Paulette Barahona, Marie Wong, Alexandra Sherstyuk, Glenn M. Marshall, Vanessa Tyrrell, Eva A. Wegner, Paul G. Ekert, Mark J. Cowley, Chelsea Mayoh, Toby N. Trahair, Philip Crowe, Antoinette Anazodo, David S. Ziegler

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Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance by Mohamed Fareh, Wei Zhao, Wenxin Hu, Joshua M. L. Casan, Amit Kumar, Jori Symons, Jennifer M. Zerbato, Danielle Fong, Ilia Voskoboinik, Paul G. Ekert, Rajeev Rudraraju, Damian F. J. Purcell, Sharon R. Lewin, Joseph A. Trapani

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Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. by Daniel Thomas, Jason A Powell, Benjamin D Green, Emma F Barry, Yuefang Ma, Joanna Woodcock, Stephen Fitter, Andrew C W Zannettino, Stuart M Pitson, Timothy P Hughes, Angel F Lopez, Peter R Shepherd, Andrew H Wei, Paul G Ekert, Mark A Guthridge

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A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax by Hansen J. Kosasih, Gerry Healey, Margs S. Brennan, Stefan Bjelosevic, Teresa Sadras, Fatimah B. Jalud, Tasnia Ibnat, Ashley P. Ng, Chelsea Mayoh, Jie Mao, Gabor Tax, Louise E. A. Ludlow, Ricky W. Johnstone, Marco J. Herold, Seong L. Khaw, Charles E. deBock, Paul G. Ekert

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Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes by Pamela Ajuyah, Chelsea Mayoh, Loretta M. S. Lau, Paulette Barahona, Marie Wong, Hazel Chambers, Fatima Valdes-Mora, Akanksha Senapati, Andrew J. Gifford, Colleen D’Arcy, Jordan R. Hansford, Neevika Manoharan, Wayne Nicholls, Molly M. Williams, Paul J. Wood, Mark J. Cowley, Vanessa Tyrrell, Michelle Haber, Paul G. Ekert, David S. Ziegler, Dong-Anh Khuong-Quang

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Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer by Maria Tsoli, Carol Wadham, Mark Pinese, Tim Failes, Swapna Joshi, Emily Mould, Julia X. Yin, Velimir Gayevskiy, Amit Kumar, Warren Kaplan, Paul G. Ekert, Federica Saletta, Laura Franshaw, Jie Liu, Andrew Gifford, Martin A. Weber, Michael Rodriguez, Richard J. Cohn, Greg Arndt, Vanessa Tyrrell, Michelle Haber, Toby Trahair, Glenn M. Marshall, Kerrie McDonald, Mark J. Cowley, David S. Ziegler

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A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer by Chelsea Mayoh, Andrew J. Gifford, Rachael Terry, Loretta M. S. Lau, Marie Wong, Padmashree Rao, Tyler Shai-Hee, Federica Saletta, Dong-Anh Khuong-Quang, Vicky Qin, Marion K. Mateos, Deborah Meyran, Katherine E. Miller, Aysen Yuksel, Emily V. A. Mould, Rachel Bowen-James, Dinisha Govender, Akanksha Senapati, Nataliya Zhukova, Natacha Omer, Hetal Dholaria, Frank Alvaro, Heather Tapp, Yonatan Diamond, Luciano Dalla Pozza, Andrew S. Moore, Wayne Nicholls, Nicholas G. Gottardo, Geoffrey McCowage, Jordan R. Hansford, Seong-Lin Khaw, Paul J. Wood, Daniel Catchpoole, Catherine E. Cottrell, Elaine R. Mardis, Glenn M. Marshall, Vanessa Tyrrell, Michelle Haber, David S. Ziegler, Orazio Vittorio, Joseph A. Trapani, Mark J. Cowley, Paul J. Neeson, Paul G. Ekert

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In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer by Loretta M S Lau, Chelsea Mayoh, Jinhan Xie, Paulette Barahona, Karen L MacKenzie, Marie Wong, Alvin Kamili, Maria Tsoli, Tim W Failes, Amit Kumar, Emily V A Mould, Andrew Gifford, Shu‐Oi Chow, Mark Pinese, Jamie I Fletcher, Greg M Arndt, Dong‐Anh Khuong‐Quang, Carol Wadham, Daniel Batey, Georgina Eden, Peter Trebilcock, Swapna Joshi, Stephanie Alfred, Anjana Gopalakrishnan, Aaminah Khan, Dylan Grebert Wade, Patrick A Strong, Elodie Manouvrier, Lisa T Morgan, Miriam Span, Jin Yi Lim, Roxanne Cadiz, Caitlin Ung, David M Thomas, Katherine M Tucker, Meera Warby, Geoffrey B McCowage, Luciano Dalla‐Pozza, Jennifer A Byrne, Federica Saletta, Andrew Fellowes, Stephen B Fox, Murray D Norris, Vanessa Tyrrell, Toby N Trahair, Richard B Lock, Mark J Cowley, Paul G Ekert, Michelle Haber, David S Ziegler, Glenn M Marshall

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