A framework for extending trial design to facilitate missing data sensitivity analyses by Alexina J. Mason, Richard D. Grieve, Alvin Richards-Belle, Paul R. Mouncey, David A. Harrison, James R. Carpenter

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First-line support for assistance in breathing in children: statistical and health economic analysis plan for the FIRST-ABC trial by Izabella Orzechowska, M. Zia Sadique, Karen Thomas, Peter Davis, Kevin P. Morris, Paul R. Mouncey, Mark J. Peters, Alvin Richards-Belle, Lyvonne N. Tume, Padmanabhan Ramnarayan, David A. Harrison

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Treatment strategies for new onset atrial fibrillation in patients treated on an intensive care unit: a systematic scoping review by Laura Drikite, Jonathan P. Bedford, Liam O’Bryan, Tatjana Petrinic, Kim Rajappan, James Doidge, David A. Harrison, Kathryn M. Rowan, Paul R. Mouncey, Duncan Young, Peter J. Watkinson, Mark Corbett

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Restricted fluid bolus versus current practice in children with septic shock: the FiSh feasibility study and pilot RCT by David Inwald, Ruth R Canter, Kerry Woolfall, Caitlin B O’Hara, Paul R Mouncey, Zohra Zenasni, Nicholas Hudson, Steven Saunders, Anjali Carter, Nicola Jones, Mark D Lyttle, Simon Nadel, Mark J Peters, David A Harrison, Kathryn M Rowan

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A nurse-led, preventive, psychological intervention to reduce PTSD symptom severity in critically ill patients: the POPPI feasibility study and cluster RCT by Paul R Mouncey, Dorothy Wade, Alvin Richards-Belle, Zia Sadique, Jerome Wulff, Richard Grieve, Lydia M Emerson, Chris R Brewin, Sheila Harvey, David Howell, Nicholas Hudson, Imran Khan, Monty Mythen, Deborah Smyth, John Weinman, John Welch, David A Harrison, Kathryn M Rowan

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Protocolised Management In Sepsis (ProMISe): a multicentre randomised controlled trial of the clinical effectiveness and cost-effectiveness of early, goal-directed, protocolised re... by Paul R Mouncey, Tiffany M Osborn, G Sarah Power, David A Harrison, M Zia Sadique, Richard D Grieve, Rahi Jahan, Jermaine CK Tan, Sheila E Harvey, Derek Bell, Julian F Bion, Timothy J Coats, Mervyn Singer, J Duncan Young, Kathryn M Rowan

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Use of selective gut decontamination in critically ill children: PICnIC a pilot RCT and mixed-methods study by Alanna Brown, Paloma Ferrando-Vivas, Mariana Popa, Gema Milla de la Fuente, John Pappachan, Brian H Cuthbertson, Laura Drikite, Richard Feltbower, Theodore Gouliouris, Isobel Sale, Robert Shulman, Lyvonne N Tume, John Myburgh, Kerry Woolfall, David A Harrison, Paul R Mouncey, Kathryn Rowan, Nazima Pathan

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Reduced exposure to vasopressors through permissive hypotension to reduce mortality in critically ill people aged 65 and over: the 65 RCT by Paul R Mouncey, Alvin Richards-Belle, Karen Thomas, David A Harrison, M Zia Sadique, Richard D Grieve, Julie Camsooksai, Robert Darnell, Anthony C Gordon, Doreen Henry, Nicholas Hudson, Alexina J Mason, Michelle Saull, Chris Whitman, J Duncan Young, François Lamontagne, Kathryn M Rowan, the 65 trial investigators

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Different temperature thresholds for antipyretic intervention in critically ill children with fever due to infection: the FEVER feasibility RCT by Mark J Peters, Imran Khan, Kerry Woolfall, Elizabeth Deja, Paul R Mouncey, Jerome Wulff, Alexina Mason, Rachel Agbeko, Elizabeth S Draper, Blaise Fenn, Doug W Gould, Abby Koelewyn, Nigel Klein, Christine Mackerness, Sian Martin, Lauran O’Neill, Padmanabhan Ramnarayan, Shane Tibby, Lyvonne Tume, Jason Watkins, Kent Thorburn, Paul Wellman, David A Harrison, Kathryn M Rowan

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Permissive versus restrictive temperature thresholds in critically ill children with fever and infection: a multicentre randomized clinical pilot trial by Mark J. Peters, Kerry Woolfall, Imran Khan, Elisabeth Deja, Paul R. Mouncey, Jerome Wulff, Alexina Mason, Rachel S. Agbeko, Elizabeth S. Draper, Blaise Fenn, Doug W. Gould, Abby Koelewyn, Nigel Klein, Christine Mackerness, Sian Martin, Lauran O’Neill, Samiran Ray, Padmanabhan Ramnarayan, Shane Tibby, Kentigern Thorburn, Lyvonne Tume, Jason Watkins, Paul Wellman, David A. Harrison, Kathryn M. Rowan, the FEVER Investigators on behalf of the Paediatric Intensive Care Society Study Group (PICS-SG)

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Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials by Cathrine Axfors, Perrine Janiaud, Andreas M. Schmitt, Janneke van’t Hooft, Emily R. Smith, Noah A. Haber, Akin Abayomi, Manal Abduljalil, Abdulkarim Abdulrahman, Yeny Acosta-Ampudia, Manuela Aguilar-Guisado, Farah Al-Beidh, Marissa M. Alejandria, Rachelle N. Alfonso, Mohammad Ali, Manaf AlQahtani, Alaa AlZamrooni, Juan-Manuel Anaya, Mark Angelo C. Ang, Ismael F. Aomar, Luis E. Argumanis, Alexander Averyanov, Vladimir P. Baklaushev, Olga Balionis, Thomas Benfield, Scott Berry, Nadia Birocco, Lynn B. Bonifacio, Asha C. Bowen, Abbie Bown, Carlos Cabello-Gutierrez, Bernardo Camacho, Adrian Camacho-Ortiz, Sally Campbell-Lee, Damon H. Cao, Ana Cardesa, Jose M. Carnate, German Jr. J. Castillo, Rossana Cavallo, Fazle R. Chowdhury, Forhad U. H. Chowdhury, Giovannino Ciccone, Antonella Cingolani, Fresthel Monica M. Climacosa, Veerle Compernolle, Carlo Francisco N. Cortez, Abel Costa Neto, Sergio D’Antico, James Daly, Franca Danielle, Joshua S. Davis, Francesco Giuseppe De Rosa, Justin T. Denholm, Claudia M. Denkinger, Daniel Desmecht, Juan C. Díaz-Coronado, Juan A. Díaz Ponce-Medrano, Anne-Françoise Donneau, Teresita E. Dumagay, Susanna Dunachie, Cecile C. Dungog, Olufemi Erinoso, Ivy Mae S. Escasa, Lise J. Estcourt, Amy Evans, Agnes L. M. Evasan, Christian J. Fareli, Veronica Fernandez-Sanchez, Claudia Galassi, Juan E. Gallo, Patricia J. Garcia, Patricia L. Garcia, Jesus A. Garcia, Mutien Garigliany, Elvira Garza-Gonzalez, Deonne Thaddeus V. Gauiran, Paula A. Gaviria García, Jose-Antonio Giron-Gonzalez, David Gómez-Almaguer, Anthony C. Gordon, André Gothot, Jeser Santiago Grass Guaqueta, Cameron Green, David Grimaldi, Naomi E. Hammond, Heli Harvala, Francisco M. Heralde, Jesica Herrick, Alisa M. Higgins, Thomas E. Hills, Jennifer Hines, Karin Holm, Ashraful Hoque, Eric Hoste, Jose M. Ignacio, Alexander V. Ivanov, Maike Janssen, Jeffrey H. Jennings, Vivekanand Jha, Ruby Anne N. King, Jens Kjeldsen-Kragh, Paul Klenerman, Aditya Kotecha, Fiorella Krapp, Luciana Labanca, Emma Laing, Mona Landin-Olsson, Pierre-François Laterre, Lyn-Li Lim, Jodor Lim, Oskar Ljungquist, Jorge M. Llaca-Díaz, Concepción López-Robles, Salvador López-Cárdenas, Ileana Lopez-Plaza, Josephine Anne C. Lucero, Maria Lundgren, Juan Macías, Sandy C. Maganito, Anna Flor G. Malundo, Rubén D. Manrique, Paola M. Manzini, Miguel Marcos, Ignacio Marquez, Francisco Javier Martínez-Marcos, Ana M. Mata, Colin J. McArthur, Zoe K. McQuilten, Bryan J. McVerry, David K. Menon, Geert Meyfroidt, Ma. Angelina L. Mirasol, Benoît Misset, James S. Molton, Alric V. Mondragon, Diana M. Monsalve, Parastoo Moradi Choghakabodi, Susan C. Morpeth, Paul R. Mouncey, Michel Moutschen, Carsten Müller-Tidow, Erin Murphy, Tome Najdovski, Alistair D. Nichol, Henrik Nielsen, Richard M. Novak, Matthew V. N. O’Sullivan, Julian Olalla, Akin Osibogun, Bodunrin Osikomaiya, Salvador Oyonarte, Juan M. Pardo-Oviedo, Mahesh C. Patel, David L. Paterson, Carlos A. Peña-Perez, Angel A. Perez-Calatayud, Eduardo Pérez-Alba, Anastasia Perkina, Naomi Perry, Mandana Pouladzadeh, Inmaculada Poyato, David J. Price, Anne Kristine H. Quero, Md. M. Rahman, Md. S. Rahman, Mayur Ramesh, Carolina Ramírez-Santana, Magnus Rasmussen, Megan A. Rees, Eduardo Rego, Jason A. Roberts, David J. Roberts, Yhojan Rodríguez, Jesús Rodríguez-Baño, Benjamin A. Rogers, Manuel Rojas, Alberto Romero, Kathryn M. Rowan, Fabio Saccona, Mehdi Safdarian, Maria Clariza M. Santos, Joe Sasadeusz, Gitana Scozzari, Manu Shankar-Hari, Gorav Sharma, Thomas Snelling, Alonso Soto, Pedrito Y. Tagayuna, Amy Tang, Geneva Tatem, Luciana Teofili, Steven Y. C. Tong, Alexis F. Turgeon, Januario D. Veloso, Balasubramanian Venkatesh, Yanet Ventura-Enriquez, Steve A. Webb, Lothar Wiese, Christian Wikén, Erica M. Wood, Gaukhar M. Yusubalieva, Kai Zacharowski, Ryan Zarychanski, Nina Khanna, David Moher, Steven N. Goodman, John P. A. Ioannidis, Lars G. Hemkens

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