Hyaluronic acid is associated with organ dysfunction in acute respiratory distress syndrome by Anthony J. Esposito, Pavan K. Bhatraju, Renee D. Stapleton, Mark M. Wurfel, Carmen Mikacenic

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Machine learning-based derivation and external validation of a tool to predict death and development of organ failure in hospitalized patients with COVID-19 by Yixi Xu, Anusua Trivedi, Nicholas Becker, Marian Blazes, Juan Lavista Ferres, Aaron Lee, W. Conrad Liles, Pavan K. Bhatraju

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Subphenotypes in acute kidney injury: a narrative review by Suvi T. Vaara, Pavan K. Bhatraju, Natalja L. Stanski, Blaithin A. McMahon, Kathleen Liu, Michael Joannidis, Sean M. Bagshaw

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Assessment of kidney proximal tubular secretion in critical illness by Pavan K. Bhatraju, Xin-Ya Chai, Neha A. Sathe, John Ruzinski, Edward D. Siew, Jonathan Himmelfarb, Andrew N. Hoofnagle, Mark M. Wurfel, Bryan R. Kestenbaum

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Circulating levels of soluble Fas (sCD95) are associated with risk for development of a nonresolving acute kidney injury subphenotype by Pavan K. Bhatraju, Cassianne Robinson-Cohen, Carmen Mikacenic, Susanna Harju-Baker, Victoria Dmyterko, Natalie S. J. Slivinski, W. Conrad Liles, Jonathan Himmelfarb, Susan R. Heckbert, Mark M. Wurfel

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Deep learning models for COVID-19 chest x-ray classification: Preventing shortcut learning using feature disentanglement by Anusua Trivedi, Caleb Robinson, Marian Blazes, Anthony Ortiz, Jocelyn Desbiens, Sunil Gupta, Rahul Dodhia, Pavan K. Bhatraju, W. Conrad Liles, Jayashree Kalpathy-Cramer, Aaron Y. Lee, Juan M. Lavista Ferres

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Deep learning models for COVID-19 chest x-ray classification: Preventing shortcut learning using feature disentanglement. by Anusua Trivedi, Caleb Robinson, Marian Blazes, Anthony Ortiz, Jocelyn Desbiens, Sunil Gupta, Rahul Dodhia, Pavan K Bhatraju, W Conrad Liles, Jayashree Kalpathy-Cramer, Aaron Y Lee, Juan M Lavista Ferres

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Evaluating construct validity of computable acute respiratory distress syndrome definitions in adults hospitalized with COVID-19: an electronic health records based approach by Neha A. Sathe, Su Xian, F. Linzee Mabrey, David R. Crosslin, Sean D. Mooney, Eric D. Morrell, Kevin Lybarger, Meliha Yetisgen, Gail P. Jarvik, Pavan K. Bhatraju, Mark M. Wurfel

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Identification of persistent and resolving subphenotypes of acute hypoxemic respiratory failure in two independent cohorts by Neha A. Sathe, Leila R. Zelnick, Carmen Mikacenic, Eric D. Morrell, Pavan K. Bhatraju, J. Brennan McNeil, Susanna Kosamo, Catherine L. Hough, W. Conrad Liles, Lorraine B. Ware, Mark M. Wurfel

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Clinical presentation, complications, and outcomes of hospitalized COVID‐19 patients in an academic center with a centralized palliative care consult service by Sarah M. Baker, Doug J. Leedy, Jesse Abbott Klafter, Yilin Zhang, Kayla M. Secrest, Tristan R. Osborn, Richard K. Cheng, Seth D. Judson, Susan E. Merel, Carmen Mikacenic, Pavan K. Bhatraju, W. Conrad Liles

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Mitochondrial N-formyl methionine peptides contribute to exaggerated neutrophil activation in patients with COVID-19 by Runa Kuley, Bhargavi Duvvuri, Jeffrey J. Wallin, Nam Bui, Mary Vic Adona, Nicholas G. O’Connor, Sharon K. Sahi, Ian B. Stanaway, Mark M. Wurfel, Eric D. Morrell, W. Conrad Liles, Pavan K. Bhatraju, Christian Lood

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Presence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus-2 on Admission Is Associated With Decreased Mortality in COVID-19 Critical Illness by F. Linzee Mabrey, MD, Leila R. Zelnick, PhD, Eric D. Morrell, MD, Nicholas G. O’Connor, BS, Andrew Hart, BA, Mark M. Wurfel, MD, PhD, W. Conrad Liles, MD, PhD, Pavan K. Bhatraju, MD, MSc

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Inflammation, endothelial injury, and the acute respiratory distress syndrome after out-of-hospital cardiac arrest by Sarah C. Katsandres, Jane Hall, Kyle Danielson, Sana Sakr, Sarah G. Dean, David J. Carlbom, Mark M. Wurfel, Pavan K. Bhatraju, Joseph A. Hippensteel, Eric P. Schmidt, Kaori Oshima, Catherine R. Counts, Michael R. Sayre, Daniel J. Henning, Nicholas J. Johnson

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Plasma Interleukin-6 Predicts Clinical Decline After Completion of Dexamethasone Therapy in Severe COVID-19 by F. Linzee Mabrey, MD, Pavan K. Bhatraju, MD, MSc, Eric D. Morrell, MD, Leila R. Zelnick, PhD, Neha A. Sathe, MD, Nicholas G. O’Connor, BS, Carmen Mikacenic, MD, Thomas R. Martin, MD, W. Conrad Liles, MD, PhD, Mark M. Wurfel, MD, PhD

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Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes by Pavan K. Bhatraju, Max Cohen, Ryan J. Nagao, Eric D. Morrell, Susanna Kosamo, Xin-Ya Chai, Robin Nance, Victoria Dmyterko, Joseph Delaney, Jason D. Christie, Kathleen D. Liu, Carmen Mikacenic, Sina A. Gharib, W. Conrad Liles, Ying Zheng, David C. Christiani, Jonathan Himmelfarb, Mark M. Wurfel

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Biomarker Signatures of Severe Acute Kidney Injury in a Critically Ill Cohort of COVID-19 and Non-COVID-19 Acute Respiratory Illness by Neha A. Sathe, MD, MSc, Ana Mostaghim, MD, Elizabeth Barnes, BS, Nicholas G. O’Connor, BS, Sharon K. Sahi, MS, Sana S. Sakr, PhD, Jana M. Zahlan, BS, Craig H. Smith, MD, Michael Fitzpatrick, BS, Eric D. Morrell, MD, W. Conrad Liles, MD, PhD, Pavan K. Bhatraju, MD, MSc

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Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations by Louisa Helms, Silvia Marchiano, Ian B. Stanaway, Tien-Ying Hsiang, Benjamin A. Juliar, Shally Saini, Yan Ting Zhao, Akshita Khanna, Rajasree Menon, Fadhl Alakwaa, Carmen Mikacenic, Eric D. Morrell, Mark M. Wurfel, Matthias Kretzler, Jennifer L. Harder, Charles E. Murry, Jonathan Himmelfarb, Hannele Ruohola-Baker, Pavan K. Bhatraju, Michael Gale Jr., Benjamin S. Freedman

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Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study by Pavan K. Bhatraju, Eric D. Morrell, Leila Zelnick, Neha A. Sathe, Xin-Ya Chai, Sana S. Sakr, Sharon K. Sahi, Anthony Sader, Dawn M. Lum, Ted Liu, Neall Koetje, Ashley Garay, Elizabeth Barnes, Jonathan Lawson, Gail Cromer, Mary K. Bray, Sudhakar Pipavath, Bryan R. Kestenbaum, W. Conrad Liles, Susan L. Fink, T. Eoin West, Laura Evans, Carmen Mikacenic, Mark M. Wurfel

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Severe Acute Respiratory Infection—Preparedness: Protocol for a Multicenter Prospective Cohort Study of Viral Respiratory Infections by Radu Postelnicu, MD, Avantika Srivastava, MS, Pavan K. Bhatraju, MD, MSc, Mark M. Wurfelc, MD, PhD, George L. Anesi, MD, MSCE, MBE, Martin Gonzalez, MS, Adair Andrews, RN, MATD, Karen Lutrick, PhD, Vishakha K. Kumar, MD, MBA, Timothy M. Uyeki, MD, MPH, Perren J. Cobb, MD, Leopoldo N. Segal, MD, David Brett-Major, MD, MPH, Janice M. Liebler, MD, Christopher J. Kratochvil, MD, Vikramjit Mukherjee, MD, M. Jana Broadhurst, MD, PhD, DTM&H, Richard Lee, MD, David Wyles, MD, Jonathan E. Sevransky, MD, MHS, Laura Evans, MD, MSc, Douglas Landsittel, PhD, the Society of Critical Care Medicine Discovery Network Investigators

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Angiopoietin-Like4 Is a Novel Marker of COVID-19 Severity by Pavan K. Bhatraju, MD, MSc, Eric D. Morrell, MD, Ian B. Stanaway, PhD, Neha A. Sathe, MD, MSc, Avantika Srivastava, MS, Radu Postelnicu, MD, Richard Green, BS, Adair Andrews, BSN, Martin Gonzalez, BS, Christopher J. Kratochvil, MD, Vishakha K. Kumar, BS, Tien-Ying Hsiang, PhD, Michael Gale, Jr, PhD, George L. Anesi, MD, David Wyles, MD, M. Jana Broadhurst, MD, PhD, David Brett-Major, MD, MPH, Vikramjit Mukherjee, MD, Jonathan E. Sevransky, MD, Douglas Landsittel, PhD, Chi Hung, MD, William A. Altemeier, MD, Sina A. Gharib, MD, Timothy M. Uyeki, MD, MPH, J. Perren Cobb, MD, Janice M. Liebler, MD, David R. Crosslin, PhD, Gail P. Jarvik, MD, Leopoldo N. Segal, MD, Laura Evans, MD, Carmen Mikacenic, MD, Mark M. Wurfel, MD, PhD

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