scMaui: a widely applicable deep learning framework for single-cell multiomics integration in the presence of batch effects and missing data by Yunhee Jeong, Jonathan Ronen, Wolfgang Kopp, Pavlo Lutsik, Altuna Akalin

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EpiCHAOS: a metric to quantify epigenomic heterogeneity in single-cell data by Katherine Kelly, Michael Scherer, Martina Maria Braun, Pavlo Lutsik, Christoph Plass

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MethylBERT enables read-level DNA methylation pattern identification and tumour deconvolution using a Transformer-based model by Yunhee Jeong, Clarissa Gerhäuser, Guido Sauter, Thorsten Schlomm, Karl Rohr, Pavlo Lutsik

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RnBeads 2.0: comprehensive analysis of DNA methylation data by Fabian Müller, Michael Scherer, Yassen Assenov, Pavlo Lutsik, Jörn Walter, Thomas Lengauer, Christoph Bock

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P416: DNA METHYLATION-BASED CHARACTERIZATION OF ACUTE MYELOID LEUKEMIA POINTS TOWARDS KDM3B AS A 5Q HAPLOINSUFFICIENCY CANDIDATE by Katherine Kelly, Etienne Sollier, Anna Riedel, Linda Welte, Ekaterina Jahn, Hartmut Döhner, Konstanze Döhner, Pavlo Lutsik, Christoph Plass

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P440: ENHANCER HIJACKING IN COMPLEX-KARYOTYPE AML by Etienne Sollier, Anna Riedel, Katherine Kelly, Dieter Weichenhan, Ekaterina Jahn, Konstanze Döhner, Hartmut Döhner, Aurélie Ernst, Pavlo Lutsik, Christoph Plass

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Club cells employ regeneration mechanisms during lung tumorigenesis by Yuanyuan Chen, Reka Toth, Sara Chocarro, Dieter Weichenhan, Joschka Hey, Pavlo Lutsik, Stefan Sawall, Georgios T. Stathopoulos, Christoph Plass, Rocio Sotillo

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AmpliconDesign – an interactive web server for the design of high-throughput targeted DNA methylation assays by Maximilian Schönung, Jana Hess, Pascal Bawidamann, Sina Stäble, Joschka Hey, Jens Langstein, Yassen Assenov, Dieter Weichenhan, Pavlo Lutsik, Daniel B. Lipka

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Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease by Joschka Hey, Michelle Paulsen, Reka Toth, Dieter Weichenhan, Simone Butz, Jolanthe Schatterny, Reinhard Liebers, Pavlo Lutsik, Christoph Plass, Marcus A. Mall

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Neuronal ensemble-specific DNA methylation strengthens engram stability by Kubra Gulmez Karaca, Janina Kupke, David V. C. Brito, Benjamin Zeuch, Christian Thome, Dieter Weichenhan, Pavlo Lutsik, Christoph Plass, Ana M. M. Oliveira

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DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis by Nicole Y. Souren, Lisa A. Gerdes, Pavlo Lutsik, Gilles Gasparoni, Eduardo Beltrán, Abdulrahman Salhab, Tania Kümpfel, Dieter Weichenhan, Christoph Plass, Reinhard Hohlfeld, Jörn Walter

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PB1808: EPIGENETIC INHIBITOR SCREEN TO IDENTIFY THERAPEUTIC CANDIDATES FOR MNX1-OVEREXPRESSING AML by Simge Kelekci, Anna Riedel, Dieter Weichenhan, Ashish Goyal, Katherine Kelly, Marion Baehr, Birgitta Michels, Cindy Koerner, Irene Orzella, James Dunford, Pavlo Lutsik, Stefan Wiemann, Udo Oppermann, Christoph Plass

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Guidelines for cell-type heterogeneity quantification based on a comparative analysis of reference-free DNA methylation deconvolution software by Clémentine Decamps, Florian Privé, Raphael Bacher, Daniel Jost, Arthur Waguet, HADACA consortium, Eugene Andres Houseman, Eugene Lurie, Pavlo Lutsik, Aleksandar Milosavljevic, Michael Scherer, Michael G. B. Blum, Magali Richard

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Bisulfite-free epigenomics and genomics of single cells through methylation-sensitive restriction by Christoph Niemöller, Julius Wehrle, Julian Riba, Rainer Claus, Nathalie Renz, Janika Rhein, Sabine Bleul, Juliane M. Stosch, Justus Duyster, Christoph Plass, Pavlo Lutsik, Daniel B. Lipka, Michael Lübbert, Heiko Becker

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Aberrant MNX1 expression associated with t(7;12)(q36;p13) pediatric acute myeloid leukemia induces the disease through altering histone methylation by Ahmed Waraky, Anders Östlund, Tina Nilsson, Dieter Weichenhan, Pavlo Lutsik, Marion Bähr, Joschka Hey, Gürcan Tunali, Jenni Adamsson, Susanna Jacobsson, Mohammad Hamdy Abdelrazak Morsy, Susann Li, Linda Fogelstrand, Christoph Plass, Lars Palmqvist

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DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex by Gilles Gasparoni, Sebastian Bultmann, Pavlo Lutsik, Theo F. J. Kraus, Sabrina Sordon, Julia Vlcek, Vanessa Dietinger, Martina Steinmaurer, Melanie Haider, Christopher B. Mulholland, Thomas Arzberger, Sigrun Roeber, Matthias Riemenschneider, Hans A. Kretzschmar, Armin Giese, Heinrich Leonhardt, Jörn Walter

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TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3’ neo-enhancer by Charlotte Smith, Ashish Goyal, Dieter Weichenhan, Eric Allemand, Anand Mayakonda, Umut Toprak, Anna Riedel, Estelle Balducci, Manisha Manojkumar, Anastasija Pejkovska, Oliver Mücke, Etienne Sollier, Ali Bakr, Kersten Breuer, Pavlo Lutsik, Olivier Hermine, Salvatore Spicuglia, Vahid Asnafi, Christoph Plass, Aurore Touzart

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SRSF2 safeguards efficient transcription of DNA damage and repair genes by Rebecca E. Wagner, Leonie Arnetzl, Thiago Britto-Borges, Anke Heit-Mondrzyk, Ali Bakr, Etienne Sollier, Nikoletta A. Gkatza, Jasper Panten, Sylvain Delaunay, Daniela Sohn, Peter Schmezer, Duncan T. Odom, Karin Müller-Decker, Christoph Plass, Christoph Dieterich, Pavlo Lutsik, Susanne Bornelöv, Michaela Frye

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P417: GENOMIC LANDSCAPE AND PROGNOSIS IN OLDER ACUTE MYELOID LEUKEMIA PATIENTS NOT ELIGIBLE FOR INTENSIVE CHEMOTHERAPY by Ekaterina Jahn, Maral Saadati, Pierre Fenaux, Marco Gobbi, Gail Roboz, Lars Bullinger, Pavlo Lutsik, Anna Riedel, Christoph Plass, Nikolaus Jahn, Claudia Walter, Karlheinz Holzmann, Yong Hao, Sue Naim, Nicholas Schreck, Julia Krzykalla, Axel Benner, Harold Keer, Mohammad Azab, Konstanze Döhner, Hartmut Döhner

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Discovery of non-genomic drivers of YAP signaling modulating the cell plasticity in CRC tumor lines by Nobuhiko Ogasawara, Yoshihito Kano, Yosuke Yoneyama, Sakurako Kobayashi, Satoshi Watanabe, Sakura Kirino, Fausto D. Velez-Bravo, Yourae Hong, Aleksandra Ostapiuk, Pavlo Lutsik, Iichiroh Onishi, Shinichi Yamauchi, Yui Hiraguri, Go Ito, Yusuke Kinugasa, Kenichi Ohashi, Mamoru Watanabe, Ryuichi Okamoto, Sabine Tejpar, Shiro Yui

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