Editorial: Machine learning, epistasis, and protein engineering: From sequence-structure-function relationships to regulation of metabolic pathways by Frederic Cadet, Frederic Cadet, Emma Saavedra, Per-Olof Syren, Per-Olof Syren, Brigitte Gontero

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Mechanism-Guided Discovery of an Esterase Scaffold with Promiscuous Amidase Activity by Charlotte Kürten, Bengt Carlberg, Per-Olof Syrén

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MD Simulations Reveal Complex Water Paths in Squalene–Hopene Cyclase: Tunnel-Obstructing Mutations Increase the Flow of Water in the Active Site by Camilla Gustafsson, Serguei Vassiliev, Charlotte Kürten, Per-Olof Syrén, Tore Brinck

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Pinene-Based Oxidative Synthetic Toolbox for Scalable Polyester Synthesis by Arne Stamm, Johannes Öhlin, Caroline Mosbech, Peter Olsén, Boyang Guo, Elisabeth Söderberg, Antonino Biundo, Linda Fogelström, Shubhankar Bhattacharyya, Uwe T. Bornscheuer, Eva Malmström, Per-Olof Syrén

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Metabolite interactions in the bacterial Calvin cycle and implications for flux regulation by Emil Sporre, Jan Karlsen, Karen Schriever, Johannes Asplund-Samuelsson, Markus Janasch, Linnéa Strandberg, Anna Karlsson, David Kotol, Luise Zeckey, Ilaria Piazza, Per-Olof Syrén, Fredrik Edfors, Elton P. Hudson

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Ancestral lysosomal enzymes with increased activity harbor therapeutic potential for treatment of Hunter syndrome by Natalie M. Hendrikse, Anna Sandegren, Tommy Andersson, Jenny Blomqvist, Åsa Makower, Dominik Possner, Chao Su, Niklas Thalén, Agneta Tjernberg, Ulrica Westermark, Johan Rockberg, Stefan Svensson Gelius, Per-Olof Syrén, Erik Nordling

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Toughening of a Soft Polar Polythiophene through Copolymerization with Hard Urethane Segments by Sepideh Zokaei, Renee Kroon, Johannes Gladisch, Bryan D. Paulsen, Wonil Sohn, Anna I. Hofmann, Gustav Persson, Arne Stamm, Per‐Olof Syrén, Eva Olsson, Jonathan Rivnay, Eleni Stavrinidou, Anja Lund, Christian Müller

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Design, structure and plasma binding of ancestral β-CoV scaffold antigens by David Hueting, Karen Schriever, Rui Sun, Stelios Vlachiotis, Fanglei Zuo, Likun Du, Helena Persson, Camilla Hofström, Mats Ohlin, Karin Walldén, Marcus Buggert, Lennart Hammarström, Harold Marcotte, Qiang Pan-Hammarström, Juni Andréll, Per-Olof Syrén

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