Phillip Allen Sharp

Sharp with the [[Winthrop-Sears Medal]] in 2007 Phillip Allen Sharp (born June 6, 1944) is an American geneticist and molecular biologist who co-discovered RNA splicing. He shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for "the discovery that genes in eukaryotes are not contiguous strings but contain introns, and that the splicing of messenger RNA to delete those introns can occur in different ways, yielding different proteins from the same DNA sequence". He has been selected to receive the 2015 Othmer Gold Medal.

Sharp's current research focuses on small RNAs and other types of non-coding RNAs. His laboratory works to identify the target mRNAs of microRNAs (miRNAs), and has discovered a class of miRNAs that are produced from sequences adjacent to transcription start sites. His laboratory also studies how miRNA gene regulation functions in angiogenesis and cellular stress. Provided by Wikipedia
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  1. 1
    Single nucleotide polymorphism-based validation of exonic splicing enhancers.

    Single nucleotide polymorphism-based validation of exonic splicing enhancers. by William G Fairbrother, Dirk Holste, Christopher B Burge, Phillip A Sharp

    Published 2004-09-01
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  2. 2
    miRNA profiling of naïve, effector and memory CD8 T cells.

    miRNA profiling of naïve, effector and memory CD8 T cells. by Haoquan Wu, Joel R Neilson, Priti Kumar, Monika Manocha, Premlata Shankar, Phillip A Sharp, N Manjunath

    Published 2007-10-01
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  3. 3
    Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing

    Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing by Kavi Gupta, Chenxi Yang, Kayla McCue, Osbert Bastani, Phillip A. Sharp, Christopher B. Burge, Armando Solar-Lezama

    Published 2024-01-01
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  4. 4
    Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow

    Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow by Patrick A Murphy, Vincent L Butty, Paul L Boutz, Shahinoor Begum, Amy L Kimble, Phillip A Sharp, Christopher B Burge, Richard O Hynes

    Published 2018-01-01
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  5. 5
    A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells.

    A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells. by Grace X Y Zheng, Arvind Ravi, J Mauro Calabrese, Lea A Medeiros, Oktay Kirak, Lucas M Dennis, Rudolf Jaenisch, Christopher B Burge, Phillip A Sharp

    Published 2011-05-01
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  6. 6
    Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements

    Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements by Sara J.C. Gosline, Allan M. Gurtan, Courtney K. JnBaptiste, Andrew Bosson, Pamela Milani, Simona Dalin, Bryan J. Matthews, Yoon S. Yap, Phillip A. Sharp, Ernest Fraenkel

    Published 2016-01-01
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  7. 7
    1517 Mutant-p53 amplifies Cxcl1 expression from distal enhancers blunting immune checkpoint inhibition efficacy in pancreatic cancer

    1517 Mutant-p53 amplifies Cxcl1 expression from distal enhancers blunting immune checkpoint inhibition efficacy in pancreatic cancer by Stefani Spranger, Rakesh K Jain, Kim Nguyen, Arjun Bhutkar, Ivy Chen, Dig Bijay Mahat, Heena Kumra, Emily Metcalf, Sarah Castro, William W Ho, Brandon Sullivan, Leon K Yim, Vikash Chauhan, Hernandez Moura Silva, Phillip A Sharp

    Published 2023-11-01
    Article
  8. 8
    In vitro transcription studies of adenovirus

    In vitro transcription studies of adenovirus by Fire, Andrew Zachary

    Published 2015
    Other Authors: “…Phillip A. Sharp.…”
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    Thesis
  9. 9
    Dicer loss induces an oncogenic epigenetic switch in mesenchymal stem cells

    Dicer loss induces an oncogenic epigenetic switch in mesenchymal stem cells by JnBaptiste, Courtney K. (Courtney Kenneil)

    Published 2016
    Other Authors: “…Phillip A. Sharp.…”
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    Thesis
  10. 10
    The regulation of premature termination at divergent promoters

    The regulation of premature termination at divergent promoters by Chiu, Anthony Chun-yin.

    Published 2018
    Other Authors: “…Phillip A. Sharp.…”
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    Thesis
  11. 11
    Cdk12 regulates DNA repair Genes by suppressing intronic polyadenylation

    Cdk12 regulates DNA repair Genes by suppressing intronic polyadenylation by Dubbury, Sara Jane

    Published 2018
    Other Authors: “…Phillip A. Sharp.…”
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    Thesis
  12. 12
    Old protein, new perspective : the role of Oct-1 during embryonic development and lymphopoiesis

    Old protein, new perspective : the role of Oct-1 during embryonic development and lymphopoiesis by Wang, Victoria Elizabeth, 1973-

    Published 2006
    Other Authors: “…Phillip A. Sharp.…”
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    Thesis
  13. 13
    Specificity and mechanism of microRNAs in the regulation of gene expression

    Specificity and mechanism of microRNAs in the regulation of gene expression by Doench, John Gerard

    Published 2006
    Other Authors: “…Phillip A. Sharp.…”
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    Thesis
  14. 14
    TATA binding protein and associated factors in mammalian transcription : characterization of the B-TFIID activity

    TATA binding protein and associated factors in mammalian transcription : characterization of the B-TFIID activity by Meyers, Rachel Ellen

    Published 2006
    Other Authors: “…Phillip A. Sharp.…”
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    Thesis
  15. 15
    Functional specificity and design of transcription factor : the Oct-1 homeodomain

    Functional specificity and design of transcription factor : the Oct-1 homeodomain by Pomerantz, Joel Leonard

    Published 2006
    Other Authors: “…Phillip A. Sharp.…”
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    Thesis
  16. 16
    Translational regulation by short RNAs in mammalian cells

    Translational regulation by short RNAs in mammalian cells by Petersen, Christian Paul

    Published 2008
    Other Authors: “…Phillip A. Sharp.…”
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    Thesis
  17. 17
    The role of U1 and snRNP in pre-mRNA splicing

    The role of U1 and snRNP in pre-mRNA splicing by Crispino, John D. (John David)

    Published 2007
    Other Authors: “…Phillip A. Sharp.…”
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    Thesis
  18. 18
    Isolation and functional characterization of cofactors of RNA polymerase II transcription

    Isolation and functional characterization of cofactors of RNA polymerase II transcription by Kim, Jaesang

    Published 2008
    Other Authors: “…Phillip A. Sharp.…”
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    Thesis
  19. 19
    Exploring the specificity and mechanisms of siRNA-mediated gene silencing in mammalian cells

    Exploring the specificity and mechanisms of siRNA-mediated gene silencing in mammalian cells by Alemán, Lourdes Maria

    Published 2009
    Other Authors: “…Phillip A. Sharp.…”
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    Thesis
  20. 20
    Discovery of miRNA-regulated processes in mammalian development

    Discovery of miRNA-regulated processes in mammalian development by Young, Amanda Garfinkel

    Published 2010
    Other Authors: “…Phillip A. Sharp.…”
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    Thesis

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