Picower Institute for Learning and Memory

Picower Institute reflecting the [[Stata Center The Picower Institute for Learning and Memory is one of the three neuroscience groups at MIT along with the McGovern Institute for Brain Research and the Department of Brain and Cognitive Sciences. The institute focuses on studying various aspects of learning and memory, including diseases such as Alzheimer's and schizophrenia. it has received over US$50 million for research in these areas.

Establishment and Funding

The institute was established in 1994, primarily funded by the Sherman Fairchild Foundation, the RIKEN Brain Science Institute and the National Institute of Mental Health. It was renamed after receiving a $50 million grant by the Picower Foundation in 2002.

Leadership

* Founder and Former Director: Nobel Prize laureate Susumu Tonegawa, who resigned on December 31, 2006, believing that “a new generation of leadership is needed.”

* Current Director: Professor Li-Huei Tsai, who became the director on July 1, 2009 Provided by Wikipedia
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  1. 1
    Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity

    Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity by Haggarty, Stephen J., Tsai, Li-Huei

    Published 2016
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  2. 2
    Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

    Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity by Fass, Daniel M., Reis, Surya A., Ghosh, Balaram, Hennig, Krista M., Joseph, Nadine F., Zhao, Wen-Ning, Nieland, Thomas J.F., Guan, Ji-Song, Groves Kuhnle, Chelsea E., Tang, Weiping, Barker, Douglas D., Mazitschek, Ralph, Schreiber, Stuart L., Tsai, Li-Huei, Haggarty, Stephen J.

    Published 2016
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  3. 3
    Transient enhancement of proliferation of neural progenitors and impairment of their long-term survival in p25 transgenic mice

    Transient enhancement of proliferation of neural progenitors and impairment of their long-term survival in p25 transgenic mice by Zou, Donghua, Zhou, Yijing, Liu, Long, Dong, Fengping, Shu, Tianzhi, Zhou, Ying, Tsai, Li-Huei, Mao, Yingwei

    Published 2016
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  4. 4
    Glutamatergic input from specific sources influences the nucleus accumbens-ventral pallidum information flow

    Glutamatergic input from specific sources influences the nucleus accumbens-ventral pallidum information flow by Papp, Edit, Borhegyi, Zsolt, Tomioka, Ryohei, Mody, István, Freund, Tamás F., Rockland, Kathleen

    Published 2016
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  5. 5
    Fast maximum likelihood estimation using continuous-time neural point process models

    Fast maximum likelihood estimation using continuous-time neural point process models by Lepage, Kyle Q., MacDonald, Christopher J

    Published 2016
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  6. 6
    Bayesian Modelling of Induced Responses and Neuronal Rhythms

    Bayesian Modelling of Induced Responses and Neuronal Rhythms by Friston, Karl J., Pinotsis, Dimitrios, Loonis, Roman Florian, Bastos, Andre M, Miller, Earl K

    Published 2016
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  7. 7
    Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

    Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes by Raja, Waseem K, Mungenast, Alison, Lin, Yuan-Ta, Ko, Tak, Abdurrob, Fatema, Seo, Jinsoo, Tsai, Li-Huei

    Published 2017
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  8. 8
    Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD)

    Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractograp... by Makris, Nikolaos, Rathi, Yogesh, Mouradian, Palig, Bonmassar, Giorgio, Papadimitriou, George, Kubicki, Marek, Fan, Qiuyun, Nummenmaa, Aapo, Ing, Wingkwai I., Yeterian, Edward H., Eskandar, Emad N., Wald, Lawrence L., Dougherty, Darin D., Widge, Alik

    Published 2017
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  9. 9
    Enhanced inhibitory control by neuropeptide Y Y5 receptor blockade in rats

    Enhanced inhibitory control by neuropeptide Y Y5 receptor blockade in rats by Dec, A., Lee, J., Song, D., Dale, E., Peterson, J., Zorn, S., Huang, X., Campbell, B., Lee, A. W., Robbins, T. W., West, A. R., Bari, Andrea

    Published 2017
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  10. 10
    Uncovering representations of sleep-associated hippocampal ensemble spike activity

    Uncovering representations of sleep-associated hippocampal ensemble spike activity by Chen, Zhe, Grosmark, Andres D., Penagos, Hector L., Wilson, Matthew A

    Published 2017
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  11. 11
    Memory engram storage and retrieval

    Memory engram storage and retrieval by Tonegawa, Susumu, Pignatelli di Spinazzola, Michele, Roy, Dheeraj, Ryan, Tomas John

    Published 2017
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  12. 12
    Scalable, Lightweight, Integrated and Quick-to-Assemble (SLIQ) Hyperdrives for Functional Circuit Dissection

    Scalable, Lightweight, Integrated and Quick-to-Assemble (SLIQ) Hyperdrives for Functional Circuit Dissection by Liang, Li, Oline, Stefan N., Kirk, Justin C., Schmitt, Lukas Ian, Remondes, Miguel, Halassa, Michael M., Komorowski, Robert

    Published 2017
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  13. 13
    The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization

    The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization by Hannan, Shabab B., Kern, Jeannine V., Stanchev, Doychin T., Jahn, Thomas R., Rasse, Tobias M., Koc, Baran, Zhang, Yao

    Published 2017
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  14. 14
    β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X

    β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X by Auerbach, Benjamin D., Lefkowitz, Robert J., Stoppel, Laura Jane, Senter, Rebecca K, Preza, Anthony R., Bear, Mark

    Published 2017
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  15. 15
    Arbaclofen in fragile X syndrome: results of phase 3 trials

    Arbaclofen in fragile X syndrome: results of phase 3 trials by Berry-Kravis, Elizabeth, Hagerman, Randi, Visootsak, Jeannie, Budimirovic, Dejan, Kaufmann, Walter E., Cherubini, Maryann, Zarevics, Peter, Walton-Bowen, Karen, Wang, Paul, Bear, Mark, Carpenter, Randall L

    Published 2017
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  16. 16
    Dissecting structure–activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation

    Dissecting structure–activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation by Ghosh, Balaram, Zhao, Wen-Ning, Reis, Surya A., Patnaik, Debasis, Fass, Daniel M., Tsai, Li-Huei, Mazitschek, Ralph, Haggarty, Stephen J.

    Published 2018
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  17. 17
    Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1

    Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1 by Maher, Erin E., Welsh, Christina A., Stevens, Beth, Erisir, Alev, Schecter, Rachel Ward, Bear, Mark

    Published 2018
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  18. 18
    Ca²⁺/Calmodulin-Dependent Protein Kinase II (CaMKII) β-Dependent Phosphorylation of GABAB1 Triggers Lysosomal Degradation of GABAB Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination

    Ca²⁺/Calmodulin-Dependent Protein Kinase II (CaMKII) β-Dependent Phosphorylation of GABAB1 Triggers Lysosomal Degradation of GABAB Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-... by Zemoura, Khaled, Balakrishnan, Karthik, Grampp, Thomas, Benke, Dietmar

    Published 2018
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  19. 19
    Mate-guarding behavior enhances male reproductive success via familiarization with mating partners in medaka fish

    Mate-guarding behavior enhances male reproductive success via familiarization with mating partners in medaka fish by Yokoi, Saori, Ansai, Satoshi, Kinoshita, Masato, Naruse, Kiyoshi, Kamei, Yasuhiro, Young, Larry J., Takeuchi, Hideaki, Okuyama, Teruhiro

    Published 2018
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  20. 20
    The somatic mutations in Interferon-γ signal molecules in human uterine leiomyosarcoma

    The somatic mutations in Interferon-γ signal molecules in human uterine leiomyosarcoma by Hayashi, Takuma, Ichimura, Tomoyuki, Kasai, Mari, Ando, Hirofumi, Ida, Koichi, Kawano, Miki, Shiozawa, Tanri, Tonegawa, Susumu, Kanai, Yae, Aburatani, Hiroyuki, Yaegashi, Nobuo, Konishi, Ikuo

    Published 2018
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