Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk by Reshef, YA, Finucane, H, Kelley, DR, Gusev, A, Kotliar, D, Ulirsch, J, Hormozdiari, F, Nasser, J, O’Connor, L, van de Geijn, B, Loh, PR, Grossman, SR, Bhatia, G, Gazal, S, Pinello, L, Palamara, PF, Patterson, N, Adams, RP, Price, AL