Replication of SNP associations with keratoconus in a Czech cohort. by Petra Liskova, Lubica Dudakova, Anna Krepelova, Jiri Klema, Pirro G Hysi

Get full text

Temporal trends in frequency, type and severity of myopia and associations with key environmental risk factors in the UK: Findings from the UK Biobank Study. by Phillippa M Cumberland, Vasiliki Bountziouka, Christopher J Hammond, Pirro G Hysi, Jugnoo S Rahi, UK Biobank Eye and Vision Consortium

Get full text

Temporal trends in frequency, type and severity of myopia and associations with key environmental risk factors in the UK: Findings from the UK Biobank Study by Phillippa M. Cumberland, Vasiliki Bountziouka, Christopher J. Hammond, Pirro G. Hysi, Jugnoo S. Rahi, on behalf of the UK Biobank Eye and Vision Consortium

Get full text

Education interacts with genetic variants near GJD2, RBFOX1, LAMA2, KCNQ5 and LRRC4C to confer susceptibility to myopia. by Rosie Clark, Alfred Pozarickij, Pirro G Hysi, Kyoko Ohno-Matsui, Cathy Williams, Jeremy A Guggenheim, UK Biobank Eye and Vision Consortium

Get full text

Frequency and Distribution of Refractive Error in Adult Life: Methodology and Findings of the UK Biobank Study. by Phillippa M Cumberland, Yanchun Bao, Pirro G Hysi, Paul J Foster, Christopher J Hammond, Jugnoo S Rahi, UK Biobank Eyes & Vision Consortium

Get full text

Genome-Wide Association Analysis of Over 170,000 Individuals from the UK Biobank Identifies Seven Loci Associated with Dietary Approaches to Stop Hypertension (DASH) Diet by Olatz Mompeo, Maxim B. Freidin, Rachel Gibson, Pirro G. Hysi, Paraskevi Christofidou, Eran Segal, Ana M. Valdes, Tim D. Spector, Cristina Menni, Massimo Mangino

Get full text

Metabolome Genome-Wide Association Study Identifies 74 Novel Genomic Regions Influencing Plasma Metabolites Levels by Pirro G. Hysi, Massimo Mangino, Paraskevi Christofidou, Mario Falchi, Edward D. Karoly, NIHR Bioresource Investigators, Robert P. Mohney, Ana M. Valdes, Tim D. Spector, Cristina Menni

Get full text

Ascorbic acid metabolites are involved in intraocular pressure control in the general population by Pirro G. Hysi, Anthony P. Khawaja, Cristina Menni, Bani Tamraz, Nick Wareham, Kay-Tee Khaw, Paul J. Foster, Leslie Z. Benet, Tim D. Spector, Chris J. Hammond

Get full text

Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility by Sumana R. Chintalapudi, Doaa Maria, Xiang Di Wang, Jessica N. Cooke Bailey, NEIGHBORHOOD consortium, International Glaucoma Genetics consortium, Pirro G. Hysi, Janey L. Wiggs, Robert W. Williams, Monica M. Jablonski

Get full text

APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans. by Andrei V Tkatchenko, Tatiana V Tkatchenko, Jeremy A Guggenheim, Virginie J M Verhoeven, Pirro G Hysi, Robert Wojciechowski, Pawan Kumar Singh, Ashok Kumar, Gopal Thinakaran, Consortium for Refractive Error and Myopia (CREAM), Cathy Williams

Get full text

GWAS on retinal vasculometry phenotypes by Xiaofan Jiang, Pirro G. Hysi, Anthony P. Khawaja, Omar A. Mahroo, Zihe Xu, Christopher J. Hammond, Paul J. Foster, Roshan A. Welikala, Sarah A. Barman, Peter H. Whincup, Alicja R. Rudnicka, Christopher G. Owen, David P. Strachan

Get full text

The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation by Richard J. Acton, Wei Yuan, Fei Gao, Yudong Xia, Emma Bourne, Eva Wozniak, Jordana Bell, Karen Lillycrop, Jun Wang, Elaine Dennison, Nicholas C. Harvey, Charles A. Mein, Tim D. Spector, Pirro G. Hysi, Cyrus Cooper, Christopher G. Bell

Get full text

GWAS on retinal vasculometry phenotypes. by Xiaofan Jiang, Pirro G Hysi, Anthony P Khawaja, Omar A Mahroo, Zihe Xu, Christopher J Hammond, Paul J Foster, Roshan A Welikala, Sarah A Barman, Peter H Whincup, Alicja R Rudnicka, Christopher G Owen, David P Strachan, UK Biobank Eye and Vision Consortium

Get full text

Disentangling the genetic overlap and causal relationships between primary open-angle glaucoma, brain morphology and four major neurodegenerative disordersResearch in context by Santiago Diaz-Torres, Weixiong He, Jackson Thorp, Sahba Seddighi, Sean Mullany, Christopher J. Hammond, Pirro G. Hysi, Louis R. Pasquale, Anthony P. Khawaja, Alex W. Hewitt, Jamie E. Craig, David A. Mackey, Janey L. Wiggs, Cornelia van Duijn, Michelle K. Lupton, Jue-Sheng Ong, Stuart MacGregor, Puya Gharahkhani

Get full text

Association analyses of rare variants identify two genes associated with refractive error. by Karina Patasova, Annechien E G Haarman, Anthony M Musolf, Omar A Mahroo, Jugnoo S Rahi, Mario Falchi, Virginie J M Verhoeven, Joan E Bailey-Wilson, Caroline C W Klaver, Priya Duggal, Alison Klein, Jeremy A Guggenheim, Chris J Hammond, Pirro G Hysi, CREAM Consortium; the UK Biobank Eye; Vision Consortium

Get full text

Digital quantification of human eye color highlights genetic association of three new loci. by Fan Liu, Andreas Wollstein, Pirro G Hysi, Georgina A Ankra-Badu, Timothy D Spector, Daniel Park, Gu Zhu, Mats Larsson, David L Duffy, Grant W Montgomery, David A Mackey, Susan Walsh, Oscar Lao, Albert Hofman, Fernando Rivadeneira, Johannes R Vingerling, André G Uitterlinden, Nicholas G Martin, Christopher J Hammond, Manfred Kayser

Get full text

Common genetic variants near the Brittle Cornea Syndrome locus ZNF469 influence the blinding disease risk factor central corneal thickness. by Yi Lu, David P Dimasi, Pirro G Hysi, Alex W Hewitt, Kathryn P Burdon, Tze'Yo Toh, Jonathan B Ruddle, Yi Ju Li, Paul Mitchell, Paul R Healey, Grant W Montgomery, Narelle Hansell, Timothy D Spector, Nicholas G Martin, Terri L Young, Christopher J Hammond, Stuart Macgregor, Jamie E Craig, David A Mackey

Get full text

A multi-ancestry GWAS of Fuchs corneal dystrophy highlights the contributions of laminins, collagen, and endothelial cell regulation by Bryan R. Gorman, Michael Francis, Cari L. Nealon, Christopher W. Halladay, Nalvi Duro, Kyriacos Markianos, Giulio Genovese, Pirro G. Hysi, Hélène Choquet, Natalie A. Afshari, Yi-Ju Li, VA Million Veteran Program, J. Michael Gaziano, Adriana M. Hung, Wen-Chih Wu, Paul B. Greenberg, Saiju Pyarajan, Jonathan H. Lass, Neal S. Peachey, Sudha K. Iyengar

Get full text

Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A. by Carola Marzi, Eva Albrecht, Pirro G Hysi, Vasiliki Lagou, Melanie Waldenberger, Anke Tönjes, Inga Prokopenko, Katharina Heim, Hannah Blackburn, Janina S Ried, Marcus E Kleber, Massimo Mangino, Barbara Thorand, Annette Peters, Christopher J Hammond, Harald Grallert, Bernhard O Boehm, Peter Kovacs, Ludwig Geistlinger, Holger Prokisch, Bernhard R Winkelmann, Tim D Spector, H-Erich Wichmann, Michael Stumvoll, Nicole Soranzo, Winfried März, Wolfgang Koenig, Thomas Illig, Christian Gieger

Get full text

A genome-wide association study identifies five loci influencing facial morphology in Europeans. by Fan Liu, Fedde van der Lijn, Claudia Schurmann, Gu Zhu, M Mallar Chakravarty, Pirro G Hysi, Andreas Wollstein, Oscar Lao, Marleen de Bruijne, M Arfan Ikram, Aad van der Lugt, Fernando Rivadeneira, André G Uitterlinden, Albert Hofman, Wiro J Niessen, Georg Homuth, Greig de Zubicaray, Katie L McMahon, Paul M Thompson, Amro Daboul, Ralf Puls, Katrin Hegenscheid, Liisa Bevan, Zdenka Pausova, Sarah E Medland, Grant W Montgomery, Margaret J Wright, Carol Wicking, Stefan Boehringer, Timothy D Spector, Tomáš Paus, Nicholas G Martin, Reiner Biffar, Manfred Kayser

Get full text