406 Reprogramming the glioma immunosuppressive tumor microenvironment with engineered myeloid cells that release IL-2 to delay malignant progression by Matthew Nazzaro, Alessandro Canella, Claire Schmitt, Abigail Haffey, Giovanni Nigita, Gregory K Behbehani, Prajwal Rajappa

Primary murine high-grade glioma cells derived from RCAS/tv-a diffuse glioma model reprogram naive T cells into immunosuppressive regulatory T lymphocytes by Alessandro Canella, Mykyta Artomov, Aleksandr Ukhatov, Sakthi Rajendran, Phillip Perez, Uksha Saini, Jack Hedberg, Kevin Cassady, Prajwal Rajappa

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Pediatric versus adult high grade glioma: Immunotherapeutic and genomic considerations by Payal Aggarwal, Wen Luo, Wen Luo, Katherine C. Pehlivan, Hai Hoang, Prajwal Rajappa, Timothy P. Cripe, Kevin A. Cassady, Dean A. Lee, Mitchell S. Cairo, Mitchell S. Cairo, Mitchell S. Cairo, Mitchell S. Cairo

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Genetically modified IL2 bone-marrow-derived myeloid cells reprogram the glioma immunosuppressive tumor microenvironment by Alessandro Canella, Matthew Nazzaro, Sakthi Rajendran, Claire Schmitt, Abigail Haffey, Giovanni Nigita, Diana Thomas, Justin M. Lyberger, Gregory K. Behbehani, Nduka M. Amankulor, Elaine R. Mardis, Timothy P. Cripe, Prajwal Rajappa

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BRAF V600E in a preclinical model of pleomorphic Xanthoastrocytoma: Analysis of the tumor microenvironment and immune cell infiltration dynamics in vivo by Alessandro Canella, Matthew Nazzaro, Mykyta Artomov, Lakshmi Prakruthi Rao Venkata, Diana Thomas, Justin Lyberger, Aleksandr Ukhatov, Yao Lulu Xing, Katherine Miller, Gregory Behbehani, Nduka M. Amankulor, Claudia Katharina Petritsch, Prajwal Rajappa

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Trabectedin promotes oncolytic virus antitumor efficacy, viral gene expression, and immune effector function in models of bone sarcoma by Emily M. Ringwalt, Mark A. Currier, Andrea M. Glaspell, Chun-Yu Chen, Matthew V. Cannon, Maren Cam, Amy C. Gross, Matthew Gust, Pin-Yi Wang, Louis Boon, Laura E. Biederman, Emily Schwarz, Prajwal Rajappa, Dean A. Lee, Elaine R. Mardis, William E. Carson, 3rd, Ryan D. Roberts, Timothy P. Cripe

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Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma by Sakthi Rajendran, Yang Hu, Alessandro Canella, Clayton Peterson, Amy Gross, Maren Cam, Matthew Nazzaro, Abigail Haffey, Akdes Serin-Harmanci, Rosario Distefano, Giovanni Nigita, Wesley Wang, Daniel Kreatsoulas, Zihai Li, Jesse A. Sepeda, Andrew Sas, Mark E. Hester, Katherine E. Miller, Olivier Elemento, Ryan D. Roberts, Eric C. Holland, Ganesh Rao, Elaine R. Mardis, Prajwal Rajappa

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Safety and Feasibility of Stereotactic Radiosurgery for Patients with 15 or more Brain Metastases by Rituraj Upadhyay, MD, Joshua D. Palmer, MD, Brett G. Klamer, PhD, Haley K. Perlow, MD, Jonathan E. Schoenhals, MD, Jayeeta Ghose, PhD, Prajwal Rajappa, MD, Dukagjin M. Blakaj, MD, PhD, Sasha Beyer, MD, PhD, John C. Grecula, MD, Austin J. Sim, MD, JD, Lanchun Lu, PhD, Wesley Zoller, CMD, James B. Elder, MD, Arnab Chakravarti, MD, Evan Thomas, MD, PhD, Raju R. Raval, MD, DPhil

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The MIF promoter SNP rs755622 is associated with immune activation in glioblastoma by Tyler J. Alban, Matthew M. Grabowski, Balint Otvos, Defne Bayik, Wesley Wang, Ajay Zalavadia, Vlad Makarov, Katie Troike, Mary McGraw, Anja Rabljenovic, Adam Lauko, Chase Neumann, Gustavo Roversi, Kristin A. Waite, Gino Cioffi, Nirav Patil, Thuy T. Tran, Kathleen McCortney, Alicia Steffens, C. Marcela Diaz, J. Mark Brown, Kathleen M. Egan, Craig M. Horbinski, Jill S. Barnholtz-Sloan, Prajwal Rajappa, Michael A. Vogelbaum, Richard Bucala, Timothy A. Chan, Manmeet S. Ahluwalia, Justin D. Lathia

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