Lead Discovery of Type II BRAF V600E Inhibitors Targeting the Structurally Validated DFG-Out Conformation Based upon Selected Fragments by Qingwen Zhang, Xuejin Zhang, Qidong You

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Modulation of protein fate decision by small molecules: targeting molecular chaperone machinery by Lei Wang, Xiaoli Xu, Zhengyu Jiang, Qidong You

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Forward or Backward: Lessons Learned from Small Molecule Drugs Approved by FDA from 2012 to 2022 by Mingxiao Gu, Sudan Sun, Qidong You, Lei Wang

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‘Click Chemistry’ Synthesis of Novel Natural Product-Like Caged Xanthones Bearing a 1,2,3-Triazole Moiety with Improved Druglike Properties as Orally Active Antitumor Agents by Xiang Li, Yue Wu, Yanyan Wang, Qidong You, Xiaojin Zhang

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Development of Novel Nrf2/ARE Inducers Bearing Pyrazino[2,1-a]isoquinolin Scaffold with Potent In Vitro Efficacy and Enhanced Physicochemical Properties by Hongbin Dai, Qiong Jiao, Tian Liu, Qidong You, Zhengyu Jiang

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Design, synthesis, and biological evaluation of arylmethylpiperidines as Kv1.5 potassium channel inhibitors by Lingyue Zhao, Qian Yang, Yiqun Tang, Qidong You, Xiaoke Guo

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A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions by Mengchen Lu, Xian Zhang, Jing Zhao, Qidong You, Zhengyu Jiang

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Methods for the Discovery and Identification of Small Molecules Targeting Oxidative Stress-Related Protein–Protein Interactions: An Update by Xuexuan Wu, Qiuyue Zhang, Yuqi Guo, Hengheng Zhang, Xiaoke Guo, Qidong You, Lei Wang

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Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein–Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis by Xian Zhang, Keni Cui, Xiaolu Wang, Yuanyuan Tong, Chihong Liu, Yuechao Zhu, Qidong You, Zhengyu Jiang, Xiaoke Guo

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Apoptosis-inducing activity of synthetic hydrocarbon-stapled peptides in H358 cancer cells expressing KRASG12C by Cuicui Li, Ni Zhao, Luyan An, Zhen Dai, Xiaoyi Chen, Fan Yang, Qidong You, Bin Di, Chi Hu, Lili Xu

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Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope by Sinan Ma, Jianai Ji, Yuanyuan Tong, Yuxuan Zhu, Junwei Dou, Xian Zhang, Shicheng Xu, Tianbao Zhu, Xiaoli Xu, Qidong You, Zhengyu Jiang

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Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3 by Arduino A. Mangoni, Tiziano Tuccinardi, Simona Collina, Jean Jacques Vanden Eynde, Diego Muñoz-Torrero, Rafik Karaman, Carlo Siciliano, Maria Emília de Sousa, Katalin Prokai-Tatrai, Jarkko Rautio, Catherine Guillou, Michael Gütschow, Stefania Galdiero, Hong Liu, Luigi A. Agrofoglio, Jean-Marc Sabatier, Christopher Hulme, George Kokotos, Qidong You, Paula A. C. Gomes

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