Editorial: Pathophysiological Interrelationship Between Obesity, Metabolic Diseases, and Cancer by Manuel D. Gahete, Manuel D. Gahete, Manuel D. Gahete, Manuel D. Gahete, Riccarda Granata, Raúl M. Luque, Raúl M. Luque, Raúl M. Luque, Raúl M. Luque

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A novel human tumoroid 3D model of sustained ACTH-secreting cell cultures to study critically needed therapies for Cushing's disease by Antonio C. Fuentes-Fayos, Raúl M. Luque

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Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes. by Raul M Luque, Qing Lin, José Córdoba-Chacón, Papasani V Subbaiah, Thorsten Buch, Ari Waisman, Hugo Vankelecom, Rhonda D Kineman

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The somatostatin analogue octreotide inhibits growth of small intestine neuroendocrine tumour cells. by Su-Chen Li, Cécile Martijn, Tao Cui, Ahmed Essaghir, Raúl M Luque, Jean-Baptiste Demoulin, Justo P Castaño, Kjell Öberg, Valeria Giandomenico

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Calcitriol-Mediated Hypercalcemia, Somatostatin Receptors Expression and 25-Hydroxyvitamin D3-1α- Hydroxylase in GIST Tumors by Yiraldine Herrera-Martínez, Yiraldine Herrera-Martínez, María José Contreras González, María José Contreras González, Sergio Pedraza-Arévalo, Sergio Pedraza-Arévalo, Maria del Carmen Guerrero Martínez, Maria del Carmen Guerrero Martínez, Ángela Rodrigo Martínez, Ángela Rodrigo Martínez, Alberto González Menchen, Alberto González Menchen, Maria Angeles Blanco Molina, Maria Angeles Blanco Molina, Maria Angeles Gálvez-Moreno, Maria Angeles Gálvez-Moreno, Alberto L. Moreno-Vega, Alberto L. Moreno-Vega, Raúl M. Luque, Raúl M. Luque, Raúl M. Luque, Aura D. Herrera-Martínez, Aura D. Herrera-Martínez

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A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance. by Manuel D Gahete, José Córdoba-Chacón, Marta Hergueta-Redondo, Antonio J Martínez-Fuentes, Rhonda D Kineman, Gema Moreno-Bueno, Raúl M Luque, Justo P Castaño

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Role of endogenous cortistatin in the regulation of ghrelin system expression at pancreatic level under normal and obese conditions. by Belén Chanclón, Raúl M Luque, José Córdoba-Chacón, Manuel D Gahete, Ana I Pozo-Salas, Justo P Castaño, Francisco Gracia-Navarro, Antonio J Martínez-Fuentes

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Growth hormone-releasing hormone-secreting pulmonary neuroendocrine tumor associated with pituitary hyperplasia and somatotropinoma by Elisa B. Lamback, Daniel G. Henriques, Mari C. Vazquez-Borrego, Carlos H. de Azeredo Lima, Leandro Kasuki, Raul M. Luque, Leila Chimelli, Mônica R. Gadelha

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Splicing alterations in pancreatic ductal adenocarcinoma: a new molecular landscape with translational potential by Emilia Alors-Pérez, Sergio Pedraza-Arevalo, Ricardo Blázquez-Encinas, María Trinidad Moreno-Montilla, Víctor García-Vioque, Inmaculada Berbel, Raúl M. Luque, Bruno Sainz, Alejandro Ibáñez-Costa, Justo P. Castaño

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Obesity alters gene expression for GH/IGF-I axis in mouse mammary fat pads: differential role of cortistatin and somatostatin. by Alicia Villa-Osaba, Manuel D Gahete, José Córdoba-Chacón, Luis de Lecea, Ana I Pozo-Salas, Francisco Javier Delgado-Lista, Marina Álvarez-Benito, José López-Miranda, Raúl M Luque, Justo P Castaño

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Bariatric surgery and calcifediol treatment, Gordian knot of severe-obesity-related comorbidities treatment by Aura D. Herrera-Martínez, Aura D. Herrera-Martínez, Laura L. S. Castillo-Peinado, Laura L. S. Castillo-Peinado, Laura L. S. Castillo-Peinado, Laura L. S. Castillo-Peinado, María J. Molina-Puerta, María J. Molina-Puerta, Alfonso Calañas-Continente, Alfonso Calañas-Continente, Antonio Membrives, Antonio Membrives, Juan Castilla, Juan Castilla, Marta Camacho Cardenosa, Antonio Casado-Díaz, Antonio Casado-Díaz, María A. Gálvez-Moreno, María A. Gálvez-Moreno, Manuel D. Gahete, Manuel D. Gahete, Manuel D. Gahete, José Manuel Quesada Gómez, José Manuel Quesada Gómez, José Manuel Quesada Gómez, Roger Bouillon, Feliciano Priego-Capote, Feliciano Priego-Capote, Feliciano Priego-Capote, Feliciano Priego-Capote, Raúl M. Luque, Raúl M. Luque, Raúl M. Luque

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The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype by Patrick B. Thomas, Penny Jeffery, Manuel D. Gahete, Eliza Whiteside, Carina Walpole, Michelle Maugham, Lidija Jovanovic, Jennifer Gunter, Elizabeth Williams, Colleen Nelson, Adrian Herington, Raul M. Luque, Rakesh Veedu, Lisa K. Chopin, Inge Seim

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Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV StudyResearch in context by Manuel D. Gahete, Mercedes del Rio-Moreno, Antonio Camargo, Juan F. Alcala-Diaz, Emilia Alors-Perez, Javier Delgado-Lista, Oscar Reyes, Sebastian Ventura, Pablo Perez-Martínez, Justo P. Castaño, José Lopez-Miranda, Raul M. Luque

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Decompressive Hemicraniectomy without Evacuation of Acute Intraparenchymal Hemorrhage by Cristóbal Blanco-Acevedo, Eduardo Aguera-Morales, Antonio C. Fuentes-Fayos, Nazareth Pelaez-Viña, Rosa Diaz-Pernalete, Nazaret Infante-Santos, Ana Muñoz-Jurado, Manuel F. Porras-Pantojo, Alejandro Ibáñez-Costa, Raúl M. Luque, Juan Solivera-Vela

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Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells by Antonio J. León-González, Prudencio Sáez-Martínez, Juan M. Jiménez-Vacas, Vicente Herrero-Aguayo, Antonio J. Montero-Hidalgo, Enrique Gómez-Gómez, Andrés Madrona, Justo P. Castaño, José L. Espartero, Manuel D. Gahete, Raúl M. Luque

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Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity by Julia Castillo-González, José Luis Ruiz, Ignacio Serrano-Martínez, Irene Forte-Lago, Ana Ubago-Rodriguez, Marta Caro, Jesús Miguel Pérez-Gómez, Alejandro Benítez-Troncoso, Eduardo Andrés-León, Macarena Sánchez-Navarro, Raúl M. Luque, Elena González-Rey

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Influence of dietary intervention on microvascular endothelial function in coronary patients and atherothrombotic risk of recurrence by Marta Millan-Orge, Jose D. Torres-Peña, Antonio Arenas-Larriva, Gracia M. Quintana-Navarro, Patricia Peña-Orihuela, Juan F. Alcala-Diaz, Raul M. Luque, Fernando Rodriguez-Cantalejo, Niki Katsiki, Jose Lopez-Miranda, Pablo Perez-Martinez, Javier Delgado-Lista

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Modulation of circulating levels of advanced glycation end products and its impact on intima-media thickness of both common carotid arteries: CORDIOPREV randomised controlled trial by Francisco M. Gutierrez-Mariscal, Alejandro Lopez-Moreno, Jose D. Torres-Peña, Purificacion Gomez-Luna, Antonio P. Arenas-de Larriva, Juan Luis Romero-Cabrera, Raul M. Luque, Jaime Uribarri, Pablo Perez-Martinez, Javier Delgado-Lista, Elena M. Yubero-Serrano, Jose Lopez-Miranda

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Age-dependent effect of metabolic phenotypes on carotid atherosclerotic disease in coronary heart disease patients (CORDIOPREV study) by Francisco M. Gutierrez-Mariscal, Antonio García-Ríos, Purificación Gómez-Luna, Carolina Fernández-Gandara, Magdalena P. Cardelo, Silvia de la Cruz-Ares, Fernando Rodriguez-Cantalejo, Raul M. Luque, Ana León-Acuña, Javier Delgado-Lista, Pablo Perez-Martinez, Elena M. Yubero-Serrano, Jose Lopez-Miranda

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Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing by Juan L. López‐Cánovas, Natalia Hermán‐Sánchez, Maria Trinidad Moreno‐Montilla, Mercedes del Rio‐Moreno, Emilia Alors‐Perez, Marina E. Sánchez‐Frias, Víctor Amado, Rubén Ciria, Javier Briceño, Manuel de laMata, Justo P. Castaño, Manuel Rodriguez‐Perálvarez, Raúl M. Luque, Manuel D. Gahete

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