PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers. by Filip Janku, J Jack Lee, Apostolia M Tsimberidou, David S Hong, Aung Naing, Gerald S Falchook, Siqing Fu, Rajyalakshmi Luthra, Ignacio Garrido-Laguna, Razelle Kurzrock

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Characteristics of percutaneous core biopsies adequate for next generation genomic sequencing. by Sharjeel H Sabir, Savitri Krishnamurthy, Sanjay Gupta, Gordon B Mills, Wei Wei, Andrea C Cortes, Kenna R Mills Shaw, Rajyalakshmi Luthra, Michael J Wallace

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Bone marrow pathologic abnormalities in familial platelet disorder with propensity for myeloid malignancy and germline RUNX1 mutation by Rashmi Kanagal-Shamanna, Sanam Loghavi, Courtney D. DiNardo, L. Jeffrey Medeiros, Guillermo Garcia-Manero, Elias Jabbour, Mark J. Routbort, Rajyalakshmi Luthra, Carlos E. Bueso-Ramos, Joseph D. Khoury

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Versatile ion S5XL sequencer for targeted next generation sequencing of solid tumors in a clinical laboratory. by Meenakshi Mehrotra, Dzifa Yawa Duose, Rajesh R Singh, Bedia A Barkoh, Jawad Manekia, Michael A Harmon, Keyur P Patel, Mark J Routbort, L Jeffrey Medeiros, Ignacio I Wistuba, Rajyalakshmi Luthra

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RAS and TP53 can predict survival in adults with T‐cell lymphoblastic leukemia treated with hyper‐CVAD by Ali Sakhdari, Beenu Thakral, Sanam Loghavi, Rashmi Kanagal‐Shamanna, C. Cameron Yin, Zhuang Zuo, Mark J. Routbort, Rajyalakshmi Luthra, L. Jeffrey Medeiros, Sa A. Wang, Keyur P. Patel, Chi Young Ok

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A two-gene signature, SKI and SLAMF1, predicts time-to-treatment in previously untreated patients with chronic lymphocytic leukemia. by Carmen D Schweighofer, Kevin R Coombes, Lynn L Barron, Lixia Diao, Rachel J Newman, Alessandra Ferrajoli, Susan O'Brien, William G Wierda, Rajyalakshmi Luthra, L Jeffrey Medeiros, Michael J Keating, Lynne V Abruzzo

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P729: LANDSCAPE OF GERMLINE PATHOGENIC/ LIKELY PATHOGENIC MUTATIONS INVOLVING DNA REPAIR GENES IN SOLID TUMOR PATIENTS WITH ANTECEDENT OR SUBSEQUENT MYELOID NEOPLASMS by Kimberly Hein, Sinchita Roy Chowdhuri, Courtney Dinardo, Guillermo Garcia-Manero, Keyur Patel, Mark Routbort, Richard Yang, Beenu Thakral, Guillermo Montalban-Bravo, Sanam Loghavi, L. Jeffrey Medeiros, Kelly Chien, Rajyalakshmi Luthra, Rashmi Kanagal-Shamanna

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Concurrent Mutations in <i>SF3B1</i> and <i>PHF6</i> in Myeloid Neoplasms by Zhuang Zuo, L. Jeffrey Medeiros, Sofia Garces, Mark J. Routbort, Chi Young Ok, Sanam Loghavi, Rashmi Kanagal-Shamanna, Fatima Zahra Jelloul, Guillermo Garcia-Manero, Kelly S. Chien, Keyur P. Patel, Rajyalakshmi Luthra, C. Cameron Yin

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Next-generation sequencing-based multigene mutational screening for acute myeloid leukemia using MiSeq: applicability for diagnostics and disease monitoring by Rajyalakshmi Luthra, Keyur P. Patel, Neelima G. Reddy, Varan Haghshenas, Mark J. Routbort, Michael A. Harmon, Bedia A. Barkoh, Rashmi Kanagal-Shamanna, Farhad Ravandi, Jorge E Cortes, Hagop M Kantarjian, L. Jeffrey Medeiros, Rajesh R. Singh

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Assessing PIK3CA and PTEN in Early-Phase Trials with PI3K/AKT/mTOR Inhibitors by Filip Janku, David S. Hong, Siqing Fu, Sarina A. Piha-Paul, Aung Naing, Gerald S. Falchook, Apostolia M. Tsimberidou, Vanda M. Stepanek, Stacy L. Moulder, J. Jack Lee, Rajyalakshmi Luthra, Ralph G. Zinner, Russell R. Broaddus, Jennifer J. Wheler, Razelle Kurzrock

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Simplified molecular classification of lung adenocarcinomas based on EGFR, KRAS, and TP53 mutations by Roberto Ruiz-Cordero, Junsheng Ma, Abha Khanna, Genevieve Lyons, Waree Rinsurongkawong, Roland Bassett, Ming Guo, Mark J. Routbort, Jianjun Zhang, Ferdinandos Skoulidis, John Heymach, Emily B. Roarty, Zhenya Tang, L. Jeffrey Medeiros, Keyur P. Patel, Rajyalakshmi Luthra, Sinchita Roy-Chowdhuri

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Persistent IDH1/2 mutations in remission can predict relapse in patients with acute myeloid leukemia by Chi Young Ok, Sanam Loghavi, Dawen Sui, Peng Wei, Rashmi Kanagal-Shamanna, C. Cameron Yin, Zhuang Zuo, Mark J. Routbort, Guilin Tang, Zhenya Tang, Jeffrey L. Jorgensen, Rajyalakshmi Luthra, Farhad Ravandi, Hagop M. Kantarjian, Courtney D. DiNardo, L. Jeffrey Medeiros, Sa A. Wang, Keyur P. Patel

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P583: PROGNOSTIC IMPLICATIONS OF WT1 MUTATIONS IN PATIENTS WITH DE NOVO AND RELAPSED ACUTE MYELOID LEUKEMIA IN THE ERA OF NOVEL TARGETED THERAPIES by Himachandana Atluri, Keyur Patel, Mark Routbort, Betul Oran, Ghayas Issa, Nicholas Short, Naval Daver, Tapan Kadia, Farhad Ravandi, Richard E. Champlin, Elizabeth J. Shpall, Sherry Pierce, Rashmi Kanagal-Shamanna, Chi Young Ok, Guilin Tang, Sa Wang, Rajyalakshmi Luthra, Audrey Lasrey, Bettina Nadorp, Antonia Chroni, Ann-Kathrin Eisfeld, Ioannis Aifantis, L. Jeffrey Medeiros, Courtney Dinardo, Sanam Loghavi

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Evolutionary action score identifies a subset of TP53 mutated myelodysplastic syndrome with favorable prognosis by Rashmi Kanagal-Shamanna, Guillermo Montalban-Bravo, Panagiotis Katsonis, Koji Sasaki, Caleb A. Class, Elias Jabbour, David Sallman, Anthony Michael Hunter, Christopher Benton, Kelly S. Chien, Rajyalakshmi Luthra, Carlos E. Bueso-Ramos, Tapan Kadia, Michael Andreeff, Rami S. Komrokji, Najla H Al Ali, Nicholas Short, Naval Daver, Mark J. Routbort, Joseph D. Khoury, Keyur Patel, Irene Ganan-Gomez, Yue Wei, Gautam Borthakur, Farhad Ravandi, Kim-Anh Do, Kelly A. Soltysiak, Olivier Lichtarge, L. Jeffrey Medeiros, Hagop Kantarjian, Guillermo Garcia-Manero

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590 Clinical outcomes and translational analysis of DART S1609: the thyroid cancer cohort; PD-1+ PD-L1+ TIL correlated with favorable survival by Jianhua Zhang, Hong Chen, Cara Haymaker, Elad Sharon, Razelle Kurzrock, Young Kwang Chae, Jiexin Zhang, Jack Lee, Jianjun Zhang, Ignacio Wistuba, Megan Othus, Sarah Fenton, Cristina Rodriguez, Adedayo Onitilo, Ahmad Mattour, Igor Rybkin, Christine McLeod, Helen Chen, Christopher Ryan, Melissa Plets, Charles Blanke, Gheath Al-Atrash, Rajyalakshmi Luthra, Hye Sung Kim, Dzifa Y Duose, Liam Il-Young Chung, Sandip P Patel, Yichen Lu, Edwin Roger Parra, Lorena Isabel Gomez Bolanos, Caddie Laberiano Fernandez, Luisa Solis Soto, Ganiraju Manyam, Gabby Lopez

Evolutionary Action Score of TP53 Analysis in Pathologically High-Risk Human Papillomavirus-Negative Head and Neck Cancer From a Phase 2 Clinical Trial: NRG Oncology Radiation Ther... by Chieko Michikawa, DDS, PhD, Pedro A. Torres-Saavedra, PhD, Natalie L. Silver, MD, MS, Paul M. Harari, MD, Merrill S. Kies, MD, David I. Rosenthal, MD, Quynh-Thu Le, MD, Richard C. Jordan, DDS, PhD, Dzifa Y. Duose, PhD, Saradhi Mallampati, DVM, PhD, Sanchit Trivedi, MS, Rajyalakshmi Luthra, PhD, Ignacio I. Wistuba, MD, Abdullah A. Osman, PhD, Olivier Lichtarge, MD, PhD, Robert L. Foote, MD, Upendra Parvathaneni, MBBS, D. Neil Hayes, MD, MPH, Curtis R. Pickering, PhD, Jeffrey N. Myers, MD, PhD

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