Pioglitazone and alogliptin combination therapy in type 2 diabetes: a pathophysiologically sound treatment by Curtis Triplitt, Eugenio Cersosimo, Ralph A DeFronzo

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201 Effects of GLP-1 on Glucose and Islet-Cell Secretory Responses to Protein Ingestion After Gastric Bypass or Sleeve Gastrectomy by Maria S. Rayas, Henri Honka, Ralph A DeFronzo, Amalia Gastaldelli, Marzieh Salehi

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Transcriptomics in type 2 diabetes: Bridging the gap between genotype and phenotype by Christopher P. Jenkinson, Harald H.H. Göring, Rector Arya, John Blangero, Ravindranath Duggirala, Ralph A. DeFronzo

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3069 Characterizing the Neural Signature of Metabolic Syndrome by Eithan Kotkowski, Larry R. Price, Crystal G. Franklin, Maximino Salazar, Ralph A. DeFronzo, David Glahn, John Blangero, Peter T. Fox

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Glycated hemoglobin versus oral glucose tolerance test in the identification of subjects with prediabetes in Qatari population by Saadallah Iskandar, Ayman Migahid, Dalia Kamal, Osama Megahed, Ralph A. DeFronzo, Mahmoud Zirie, Amin Jayyousi, Mahmood Al Jaidah, Muhammad Abdul-Ghani

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Bromocriptine-QR Therapy Reduces Sympathetic Tone and Ameliorates a Pro-Oxidative/Pro-Inflammatory Phenotype in Peripheral Blood Mononuclear Cells and Plasma of Type 2 Diabetes Sub... by Anthony H. Cincotta, Eugenio Cersosimo, Mariam Alatrach, Michael Ezrokhi, Christina Agyin, John Adams, Robert Chilton, Curtis Triplitt, Bindu Chamarthi, Nicholas Cominos, Ralph A. DeFronzo

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The Insulin-Sensitizer Pioglitazone Remodels Adipose Tissue Phospholipids in Humans by Juan P. Palavicini, Juan P. Palavicini, Alberto Chavez-Velazquez, Marcel Fourcaudot, Devjit Tripathy, Meixia Pan, Meixia Pan, Luke Norton, Ralph A. DeFronzo, Christopher E. Shannon

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Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp. by Cynthia L Blanco, Amalia Gastaldelli, Diana G Anzueto, Lauryn A Winter, Steven R Seidner, Donald C McCurnin, Hanyu Liang, Martin A Javors, Ralph A DeFronzo, Nicolas Musi

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Does reduced IGF-1R signaling in Igf1r+/- mice alter aging? by Alex F Bokov, Neha Garg, Yuji Ikeno, Sachin Thakur, Nicolas Musi, Ralph A DeFronzo, Ning Zhang, Rebecca C Erickson, Jon Gelfond, Gene B Hubbard, Martin L Adamo, Arlan Richardson

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Metabolic syndrome predictors of brain gray matter volume in an age-stratified community sample of 776 Mexican- American adults: Results from the genetics of brain structure image... by Eithan Kotkowski, Larry R. Price, Ralph A. DeFronzo, Crystal G. Franklin, Maximino Salazar, Amy S. Garrett, Mary Woolsey, John Blangero, Ravindranath Duggirala, David C. Glahn, David C. Glahn, Peter T. Fox, Peter T. Fox

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Proximal tubular epithelial insulin receptor mediates high-fat diet–induced kidney injury by Hak Joo Lee, Meenalakshmi M. Mariappan, Luke Norton, Terry Bakewell, Denis Feliers, Sae Byeol Oh, Andrew Donati, Cherubina S. Rubannelsonkumar, Manjeri A. Venkatachalam, Stephen E. Harris, Isabelle Rubera, Michel Tauc, Goutam Ghosh Choudhury, C. Ronald Kahn, Kumar Sharma, Ralph A. DeFronzo, Balakuntalam S. Kasinath

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APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor by Jiyoon Ryu, Amanda K. Galan, Xiaoban Xin, Feng Dong, Muhammad A. Abdul-Ghani, Lijun Zhou, Changhua Wang, Cuiling Li, Bekke M. Holmes, Lauren B. Sloane, Steven N. Austad, Shaodong Guo, Nicolas Musi, Ralph A. DeFronzo, Chuxia Deng, Morris F. White, Feng Liu, Lily Q. Dong

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Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American children by Srinivas Mummidi, Vidya S. Farook, Lavanya Reddivari, Joselin Hernandez-Ruiz, Alvaro Diaz-Badillo, Sharon P. Fowler, Roy G. Resendez, Feroz Akhtar, Donna M. Lehman, Christopher P. Jenkinson, Rector Arya, Jane L. Lynch, Jose A. Canas, Ralph A. DeFronzo, Daniel E. Hale, John Blangero, Juan Carlos Lopez-Alvarenga, Ravindranath Duggirala, Jairam K. P. Vanamala

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Acanthosis nigricans as a composite marker of cardiometabolic risk and its complex association with obesity and insulin resistance in Mexican American children. by Juan C Lopez-Alvarenga, Geetha Chittoor, Solomon F D Paul, Sobha Puppala, Vidya S Farook, Sharon P Fowler, Roy G Resendez, Joselin Hernandez-Ruiz, Alvaro Diaz-Badillo, David Salazar, Doreen D Garza, Donna M Lehman, Srinivas Mummidi, Rector Arya, Christopher P Jenkinson, Jane L Lynch, Ralph A DeFronzo, John Blangero, Daniel E Hale, Ravindranath Duggirala

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Transcriptomic identification of ADH1B as a novel candidate gene for obesity and insulin resistance in human adipose tissue in Mexican Americans from the Veterans Administration Ge... by Deidre A Winnier, Marcel Fourcaudot, Luke Norton, Muhammad A Abdul-Ghani, Shirley L Hu, Vidya S Farook, Dawn K Coletta, Satish Kumar, Sobha Puppala, Geetha Chittoor, Thomas D Dyer, Rector Arya, Melanie Carless, Donna M Lehman, Joanne E Curran, Douglas T Cromack, Devjit Tripathy, John Blangero, Ravindranath Duggirala, Harald H H Göring, Ralph A DeFronzo, Christopher P Jenkinson

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Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates. by Subhash Kamath, Alberto O Chavez, Amalia Gastaldelli, Francesca Casiraghi, Glenn A Halff, Gregory A Abrahamian, Alberto M Davalli, Raul A Bastarrachea, Anthony G Comuzzie, Rodolfo Guardado-Mendoza, Lilia M Jimenez-Ceja, Vicki Mattern, Ana Maria Paez, Andrea Ricotti, Mary E Tejero, Paul B Higgins, Iram Pablo Rodriguez-Sanchez, Devjit Tripathy, Ralph A DeFronzo, Edward J Dick, Gary W Cline, Franco Folli

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Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes by Julia K. Goodrich, Moriel Singer-Berk, Rachel Son, Abigail Sveden, Jordan Wood, Eleina England, Joanne B. Cole, Ben Weisburd, Nick Watts, Lizz Caulkins, Peter Dornbos, Ryan Koesterer, Zachary Zappala, Haichen Zhang, Kristin A. Maloney, Andy Dahl, Carlos A. Aguilar-Salinas, Gil Atzmon, Francisco Barajas-Olmos, Nir Barzilai, John Blangero, Eric Boerwinkle, Lori L. Bonnycastle, Erwin Bottinger, Donald W. Bowden, Federico Centeno-Cruz, John C. Chambers, Nathalie Chami, Edmund Chan, Juliana Chan, Ching-Yu Cheng, Yoon Shin Cho, Cecilia Contreras-Cubas, Emilio Córdova, Adolfo Correa, Ralph A. DeFronzo, Ravindranath Duggirala, Josée Dupuis, Ma Eugenia Garay-Sevilla, Humberto García-Ortiz, Christian Gieger, Benjamin Glaser, Clicerio González-Villalpando, Ma Elena Gonzalez, Niels Grarup, Leif Groop, Myron Gross, Christopher Haiman, Sohee Han, Craig L. Hanis, Torben Hansen, Nancy L. Heard-Costa, Brian E. Henderson, Juan Manuel Malacara Hernandez, Mi Yeong Hwang, Sergio Islas-Andrade, Marit E. Jørgensen, Hyun Min Kang, Bong-Jo Kim, Young Jin Kim, Heikki A. Koistinen, Jaspal Singh Kooner, Johanna Kuusisto, Soo-Heon Kwak, Markku Laakso, Leslie Lange, Jong-Young Lee, Juyoung Lee, Donna M. Lehman, Allan Linneberg, Jianjun Liu, Ruth J. F. Loos, Valeriya Lyssenko, Ronald C. W. Ma, Angélica Martínez-Hernández, James B. Meigs, Thomas Meitinger, Elvia Mendoza-Caamal, Karen L. Mohlke, Andrew D. Morris, Alanna C. Morrison, Maggie C. Y. Ng, Peter M. Nilsson, Christopher J. O’Donnell, Lorena Orozco, Colin N. A. Palmer, Kyong Soo Park, Wendy S. Post, Oluf Pedersen, Michael Preuss, Bruce M. Psaty, Alexander P. Reiner, Cristina Revilla-Monsalve, Stephen S. Rich, Jerome I. Rotter, Danish Saleheen, Claudia Schurmann, Xueling Sim, Rob Sladek, Kerrin S. Small, Wing Yee So, Timothy D. Spector, Konstantin Strauch, Tim M. Strom, E. Shyong Tai, Claudia H. T. Tam, Yik Ying Teo, Farook Thameem, Brian Tomlinson, Russell P. Tracy, Tiinamaija Tuomi, Jaakko Tuomilehto, Teresa Tusié-Luna, Rob M. van Dam, Ramachandran S. Vasan, James G. Wilson, Daniel R. Witte, Tien-Yin Wong, AMP-T2D-GENES Consortia, Noël P. Burtt, Noah Zaitlen, Mark I. McCarthy, Michael Boehnke, Toni I. Pollin, Jason Flannick, Josep M. Mercader, Anne O’Donnell-Luria, Samantha Baxter, Jose C. Florez, Daniel G. MacArthur, Miriam S. Udler

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