1205 Surmounting conventional cell therapy limitations via in situ CAR therapy using oRNA™ lipid nanoparticles by Thomas Lee, Thomas Barnes, Robert Mabry, Ashley Wong, Chris Wright, David Soto, Kevin Kauffman, Amy Becker, Alex Wesselhoeft, Allen Horhata, Akinola Emmanuel, Akshi Thakkar, Ramya Elangovan, Magnolia Chinn, Sharmistha Kundu, Kristen Ott, Trent Stevens, Yessica Wiryawan, Ian Langer, Rahul Vungutur, Corey Ciullo, Nelson Chau, Renee Wright-Michaud, Meghan Richardson, Jui Dutta-Simmons, Rena Schindler, Junghoon Yang, Paisley Haskell