Immunomodulatory regulator blockade in a viral exacerbation model of severe asthma by Ben Nicholas, Hyun-Hee Lee, Jane Guo, Milenko Cicmil, Cornelia Blume, René De Waal Malefyt, Ratko Djukanović

Get full text

Squamous Metaplasia Is Increased in the Bronchial Epithelium of Smokers with Chronic Obstructive Pulmonary Disease. by Helen M Rigden, Ahmad Alias, Thomas Havelock, Rory O'Donnell, Ratko Djukanovic, Donna E Davies, Susan J Wilson

Get full text

Biomarker-based corticosteroid adjustment in severe asthma: a modified Delphi consensus by Nicola E. Gallagher, Catherine E. Hanratty, Marc Humbert, Elisabeth Bel, Ratko Djukanovic, Valerie Hudson, Nile Amos, Liam G. Heaney

Get full text

EGF-induced bronchial epithelial cells drive neutrophil chemotactic and anti-apoptotic activity in asthma. by Mohib Uddin, Laurie C Lau, Grégory Seumois, Pandurangan Vijayanand, Karl J Staples, Dinesh Bagmane, Victoria Cornelius, Paul Dorinsky, Donna E Davies, Ratko Djukanović

Get full text

Proteomic signatures of eosinophilic and neutrophilic asthma from serum and sputumResearch in context by Khezia Asamoah, Kian Fan Chung, Nazanin Zounemat Kermani, Barbara Bodinier, Sven-Erik Dahlen, Ratko Djukanovic, Pankaj K. Bhavsar, Ian M. Adcock, Dragana Vuckovic, Marc Chadeau-Hyam

Get full text

SHARP: enabling generation of real-world evidence on a pan-European scale to improve the lives of individuals with severe asthma by Job J.M.H. van Bragt, Susanne Hansen, Ratko Djukanovic, Elisabeth H.D. Bel, Anneke ten Brinke, Scott S. Wagers, Anke H. Maitland-van der Zee, Celeste Porsbjerg

Get full text

Doxycycline for the prevention of progression of COVID-19 to severe disease requiring intensive care unit (ICU) admission: A randomized, controlled, open-label, parallel group tria... by Raja Dhar, John Kirkpatrick, Laura Gilbert, Arjun Khanna, Mahavir Madhavdas Modi, Rakesh K Chawla, Sonia Dalal, Venkata Nagarjuna Maturu, Marcel Stern, Oliver T Keppler, Ratko Djukanovic, Stephan D Gadola

Get full text

Viral infection of human lung macrophages increases PDL1 expression via IFNβ. by Karl J Staples, Ben Nicholas, Richard T McKendry, C Mirella Spalluto, Joshua C Wallington, Craig W Bragg, Emily C Robinson, Kirstin Martin, Ratko Djukanović, Tom M A Wilkinson

Get full text

A randomized controlled trial of nebulized surfactant for the treatment of severe COVID-19 in adults (COVSurf trial) by Ahilanandan Dushianthan, Howard W. Clark, David Brealey, Danny Pratt, James B. Fink, Jens Madsen, Helen Moyses, Lewis Matthews, Tracy Hussell, Ratko Djukanovic, Martin Feelisch, Anthony D. Postle, Michael P. W. Grocott

Get full text

Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma by Nazanin Zounemat Kermani, Woo-Jung Song, Yusef Badi, Ali Versi, Yike Guo, Kai Sun, Pank Bhavsar, Peter Howarth, Sven-Erik Dahlen, Peter J. Sterk, Ratko Djukanovic, Ian M. Adcock, Kian Fan Chung, U-BIOPRED Consortium

Get full text

Nebulised surfactant for the treatment of severe COVID-19 in adults (COV-Surf): A structured summary of a study protocol for a randomized controlled trial by Ahilanandan Dushianthan, Howard Clark, Jens Madsen, Robin Mogg, Lewis Matthews, Lee Berry, Jorge Bernardino de la Serna, James Batchelor, David Brealey, Tracy Hussell, Joanna Porter, Ratko Djukanovic, Martin Feelisch, Anthony Postle, Michael P. W. Grocott

Get full text

Correction to: Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma by Nazanin Zounemat Kermani, Woo-Jung Song, Yusef Badi, Ali Versi, Yike Guo, Kai Sun, Pank Bhavsar, Peter Howarth, Sven-Erik Dahlen, Peter J. Sterk, Ratko Djukanovic, Ian M. Adcock, Kian Fan Chung, U-BIOPRED Consortium

Get full text

Viral Inhibition of Bacterial Phagocytosis by Human Macrophages: Redundant Role of CD36. by Grace E Cooper, Zoe C Pounce, Joshua C Wallington, Leidy Y Bastidas-Legarda, Ben Nicholas, Chiamaka Chidomere, Emily C Robinson, Kirstin Martin, Anna S Tocheva, Myron Christodoulides, Ratko Djukanovic, Tom M A Wilkinson, Karl J Staples

Get full text

Blueprint for harmonising unstandardised disease registries to allow federated data analysis: prepare for the future by Johannes A. Kroes, Aruna T. Bansal, Emmanuelle Berret, Nils Christian, Andreas Kremer, Anna Alloni, Matteo Gabetta, Chris Marshall, Scott Wagers, Ratko Djukanovic, Celeste Porsbjerg, Dominique Hamerlijnck, Olivia Fulton, Anneke ten Brinke, Elisabeth H. Bel, Jacob K. Sont

Get full text

Nebulised interferon-β1a (SNG001) in hospitalised COVID-19: SPRINTER phase III study by Phillip D. Monk, Jody L. Brookes, Victoria J. Tear, Toby N. Batten, Marcin Mankowski, Tatjana Adzic-Vukicevic, Michael G. Crooks, Davinder P.S. Dosanjh, Monica Kraft, Christopher E. Brightling, Felicity J. Gabbay, Stephen T. Holgate, Ratko Djukanovic, Tom M.A. Wilkinson

Get full text

Nebulised interferon beta-1a (SNG001) in the treatment of viral exacerbations of COPD by Phillip D. Monk, Jody L. Brookes, Victoria J. Tear, Toby N. Batten, Clare Newall, Marcin Mankowski, Michael G. Crooks, Dave Singh, Rekha Chaudhuri, Brian Leaker, Kerry Lunn, Sophie Reynolds, Sarah Dudley, Felicity J. Gabbay, Stephen T. Holgate, Ratko Djukanovic, Thomas MA Wilkinson

Get full text

What bothers severe asthma patients most? A paired patient–clinician study across seven European countries by Ben Ainsworth, Eleanor Chatburn, Aruna T. Bansal, Olivia Fulton, Dominique Hamerlijnck, Courtney Coleman, Katrien Eger, Michael Hyland, Joshua Holmes, Liam Heaney, Vratislav Sedlák, Sabina Škrgat, Natalija Edelbaher, Anneke ten Brinke, Celeste Porsbjerg, Mina Gaga, Claudia Loureiro, Ratko Djukanovic, Emmanuelle Berret, Namhee Kwon

Get full text

Large scale clinical trials: lessons from the COVID-19 pandemic by Ling-Pei Ho, Liam G Heaney, Ran Wang, Chris Brightling, Joanna Porter, Stefan J Marciniak, Tom Wilkinson, Jane C Davies, Laurence Pearmain, Alex R Horsley, Lorcan P McGarvey, Ratko Djukanović, Nick Schindler, Sean Knight, Miriam Bennett, Rebecca C Robey, Tracy Hussell

Get full text

Endotypes of severe neutrophilic and eosinophilic asthma from multi‐omics integration of U‐BIOPRED sputum samples by Nazanin Zounemat Kermani, Chuan‐Xing Li, Ali Versi, Yusef Badi, Kai Sun, Mahmoud I Abdel‐Aziz, Martina Bonatti, Anke‐Hilse Maitland‐van der Zee, Ratko Djukanovic, Åsa Wheelock, Sven‐Erik Dahlen, Peter Howarth, Yike Guo, Kian Fan Chung, Ian M. Adcock, U‐BIOPRED Project Team

Get full text

A severe asthma phenotype of excessive airway Haemophilus influenzae relative abundance associated with sputum neutrophilia by Ali Versi, Adnan Azim, Fransiskus Xaverius Ivan, Mahmoud I Abdel‐Aziz, Stewart Bates, John Riley, Mohib Uddin, Nazanin Zounemat Kermani, Anke‐H Maitland‐Van Der Zee, Sven‐Eric Dahlen, Ratko Djukanovic, Sanjay H Chotirmall, Peter Howarth, Ian M Adcock, Kian Fan Chung, the U‐BIOPRED study group

Get full text