Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis. by Marie-Jo Halaby, Anne Hakem, Li Li, Samah El Ghamrasni, Shriram Venkatesan, Prakash M Hande, Otto Sanchez, Razqallah Hakem

Get full text

LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction by Jiong Li, Xiaohong Chen, Xiangming Ding, Yingduan Cheng, Bin Zhao, Zhi-chun Lai, Khalid Al Hezaimi, Razqallah Hakem, Kun-liang Guan, Cun-Yu Wang

Get full text

SARS-CoV-2 targets ribosomal RNA biogenesis by V. Talya Yerlici, Audrey Astori, Nevraj S. Kejiou, Chris A. Jordan, Negin Khosraviani, Janet N.Y. Chan, Razqallah Hakem, Brian Raught, Alexander F. Palazzo, Karim Mekhail

Get full text

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. by Toshiyuki Bohgaki, Miyuki Bohgaki, Renato Cardoso, Stephanie Panier, Dimphy Zeegers, Li Li, Grant S Stewart, Otto Sanchez, M Prakash Hande, Daniel Durocher, Anne Hakem, Razqallah Hakem

Get full text

A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity by Erin Sellars, Margarita Savguira, Jie Wu, Sabrina Cancelliere, Mark Jen, Rehna Krishnan, Anne Hakem, Dalia Barsyte-Lovejoy, Razqallah Hakem, Steven A. Narod, Joanne Kotsopoulos, Leonardo Salmena

Get full text

Nucleolar Pol II interactome reveals TBPL1, PAF1, and Pol I at intergenic rDNA drive rRNA biogenesis by Negin Khosraviani, V. Talya Yerlici, Jonathan St-Germain, Yi Yang Hou, Shi Bo Cao, Carla Ghali, Michael Bokros, Rehna Krishnan, Razqallah Hakem, Stephen Lee, Brian Raught, Karim Mekhail

Get full text

Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer. by Samah El Ghamrasni, Ashwin Pamidi, Marie Jo Halaby, Miyuki Bohgaki, Renato Cardoso, Li Li, Shriram Venkatesan, Swaminathan Sethu, Atsushi Hirao, Tak W Mak, Manoor Prakash Hande, Anne Hakem, Razqallah Hakem

Get full text

Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity. by Maryla Krajewska, Zerong You, Juan Rong, Christina Kress, Xianshu Huang, Jinsheng Yang, Tiffany Kyoda, Ricardo Leyva, Steven Banares, Yue Hu, Chia-Hung Sze, Michael J Whalen, Leonardo Salmena, Razqallah Hakem, Brian P Head, John C Reed, Stan Krajewski

Get full text

Systemic ceramide accumulation leads to severe and varied pathological consequences by Abdulfatah M. Alayoubi, James C. M. Wang, Bryan C. Y. Au, Stéphane Carpentier, Virginie Garcia, Shaalee Dworski, Samah El‐Ghamrasni, Kevin N. Kirouac, Mathilde J. Exertier, Zi Jian Xiong, Gilbert G. Privé, Calogera M. Simonaro, Josefina Casas, Gemma Fabrias, Edward H. Schuchman, Patricia V. Turner, Razqallah Hakem, Thierry Levade, Jeffrey A. Medin

Get full text

Role of Pirh2 in mediating the regulation of p53 and c-Myc. by Anne Hakem, Miyuki Bohgaki, Bénédicte Lemmers, Elisabeth Tai, Leonardo Salmena, Elzbieta Matysiak-Zablocki, Yong-Sam Jung, Jana Karaskova, Lilia Kaustov, Shili Duan, Jason Madore, Paul Boutros, Yi Sheng, Marta Chesi, P Leif Bergsagel, Bayardo Perez-Ordonez, Anne-Marie Mes-Masson, Linda Penn, Jeremy Squire, Xinbin Chen, Igor Jurisica, Cheryl Arrowsmith, Otto Sanchez, Samuel Benchimol, Razqallah Hakem

Get full text

Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages by Hyeyeon Kim, Kazeera Aliar, Pirashaanthy Tharmapalan, Curtis W. McCloskey, Abhijith Kuttanamkuzhi, Barbara T. Grünwald, Luis Palomero, Mathepan J. Mahendralingam, Matthew Waas, Arvind S. Mer, Mitchell J. Elliott, Bowen Zhang, Khalid N. Al-Zahrani, Ellen R. Langille, Michael Parsons, Swami Narala, Stefan Hofer, Paul D. Waterhouse, Razqallah Hakem, Benjamin Haibe-Kains, Thomas Kislinger, Daniel Schramek, David W. Cescon, Miquel A. Pujana, Hal K. Berman, Rama Khokha

Get full text

Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages by Hyeyeon Kim, Kazeera Aliar, Pirashaanthy Tharmapalan, Curtis W. McCloskey, Abhijith Kuttanamkuzhi, Barbara T. Grünwald, Luis Palomero, Mathepan J. Mahendralingam, Matthew Waas, Arvind S. Mer, Mitchell J. Elliott, Bowen Zhang, Khalid N. Al-Zahrani, Ellen R. Langille, Michael Parsons, Swami Narala, Stefan Hofer, Paul D. Waterhouse, Razqallah Hakem, Benjamin Haibe-Kains, Thomas Kislinger, Daniel Schramek, David W. Cescon, Miquel A. Pujana, Hal K. Berman, Rama Khokha

Get full text