Structure-guided alterations of the gp41-directed HIV-1 broadly neutralizing antibody 2F5 reveal new properties regarding its neutralizing function. by Javier Guenaga, Richard T Wyatt

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Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage by Lifei Yang, Shailendra Kumar Sharma, Christopher Cottrell, Javier Guenaga, Karen Tran, Richard Wilson, Anna-Janina Behrens, Max Crispin, Max Crispin, Max Crispin, Natalia de Val, Richard T. Wyatt, Richard T. Wyatt, Richard T. Wyatt

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Antigen-Specific Single B Cell Sorting and Monoclonal Antibody Cloning in Guinea Pigs by Lin Lei, Karen Tran, Yimeng Wang, James J. Steinhardt, Yongli Xiao, Chi-I Chiang, Richard T. Wyatt, Richard T. Wyatt, Yuxing Li, Yuxing Li

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Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response by Shridhar Bale, Lifei Yang, Mehrdad Alirezaei, Richard Wilson, Takayuki Ota, Esmeralda D. Doyle, Christopher A. Cottrell, Javier Guenaga, Karen Tran, Wenjuan Li, Leonidas Stamatatos, Leonidas Stamatatos, David Nemazee, Andrew B. Ward, Andrew B. Ward, Andrew B. Ward, Richard T. Wyatt, Richard T. Wyatt, Richard T. Wyatt

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Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies by Shridhar Bale, Alexandra Martiné, Richard Wilson, Anna-Janina Behrens, Valérie Le Fourn, Natalia de Val, Natalia de Val, Shailendra K. Sharma, Karen Tran, Jonathan L. Torres, Jonathan L. Torres, Jonathan L. Torres, Pierre-Alain Girod, Andrew B. Ward, Andrew B. Ward, Andrew B. Ward, Max Crispin, Max Crispin, Max Crispin, Richard T. Wyatt, Richard T. Wyatt, Richard T. Wyatt

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Calcium Phosphate Nanoparticle-Based Vaccines as a Platform for Improvement of HIV-1 Env Antibody Responses by Intrastructural Help by Dominik Damm, Leonardo Rojas-Sánchez, Hannah Theobald, Viktoriya Sokolova, Richard T. Wyatt, Klaus Überla, Matthias Epple, Vladimir Temchura

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Sudan Ebolavirus VP35-NP Crystal Structure Reveals a Potential Target for Pan-Filovirus Treatment by Sara Landeras-Bueno, Shun-ichiro Oda, Michael J. Norris, Zhe Li Salie, Javier Guenaga, Richard T. Wyatt, Erica Ollmann Saphire

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Cleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine Design by Shailendra Kumar Sharma, Natalia de Val, Shridhar Bale, Javier Guenaga, Karen Tran, Yu Feng, Viktoriya Dubrovskaya, Andrew B. Ward, Richard T. Wyatt

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Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response. by Viktoriya Dubrovskaya, Javier Guenaga, Natalia de Val, Richard Wilson, Yu Feng, Arlette Movsesyan, Gunilla B Karlsson Hedestam, Andrew B Ward, Richard T Wyatt

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Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice by Martina Soldemo, Monika Àdori, Julian M. Stark, Yu Feng, Karen Tran, Richard Wilson, Lifei Yang, Javier Guenaga, Richard T. Wyatt, Gunilla B. Karlsson Hedestam

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The HIV-1 Envelope Glycoprotein C3/V4 Region Defines a Prevalent Neutralization Epitope following Immunization by Lin Lei, Yuhe R. Yang, Karen Tran, Yimeng Wang, Chi-I Chiang, Gabriel Ozorowski, Yongli Xiao, Andrew B. Ward, Richard T. Wyatt, Yuxing Li

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Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies. by Yu Feng, Karen Tran, Shridhar Bale, Shailendra Kumar, Javier Guenaga, Richard Wilson, Natalia de Val, Heather Arendt, Joanne DeStefano, Andrew B Ward, Richard T Wyatt

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HIV-1 receptor binding site-directed antibodies using a VH1-2 gene segment orthologue are activated by Env trimer immunization. by Marjon Navis, Karen Tran, Shridhar Bale, Ganesh E Phad, Javier Guenaga, Richard Wilson, Martina Soldemo, Krisha McKee, Christopher Sundling, John Mascola, Yuxing Li, Richard T Wyatt, Gunilla B Karlsson Hedestam

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Structure-based stabilization of HIV-1 gp120 enhances humoral immune responses to the induced co-receptor binding site. by Barna Dey, Krisha Svehla, Ling Xu, Dianne Wycuff, Tongqing Zhou, Gerald Voss, Adhuna Phogat, Bimal K Chakrabarti, Yuxing Li, George Shaw, Peter D Kwong, Gary J Nabel, John R Mascola, Richard T Wyatt

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B cell recognition of the conserved HIV-1 co-receptor binding site is altered by endogenous primate CD4. by Mattias N E Forsell, Barna Dey, Andreas Mörner, Krisha Svehla, Sijy O'dell, Carl-Magnus Högerkorp, Gerald Voss, Rigmor Thorstensson, George M Shaw, John R Mascola, Gunilla B Karlsson Hedestam, Richard T Wyatt

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Rhesus Macaque B-Cell Responses to an HIV-1 Trimer Vaccine Revealed by Unbiased Longitudinal Repertoire Analysis by Kaifan Dai, Linling He, Salar N. Khan, Sijy O’Dell, Krisha McKee, Karen Tran, Yuxing Li, Christopher Sundling, Charles D. Morris, John R. Mascola, Gunilla B. Karlsson Hedestam, Richard T. Wyatt, Jiang Zhu

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Design and Functional Characterization of HIV-1 Envelope Protein-Coupled T Helper Liposomes by Dominik Damm, Ehsan Suleiman, Hannah Theobald, Jannik T. Wagner, Mirjam Batzoni, Bianca Ahlfeld (née Kohlhauser), Bernd Walkenfort, Jens-Christian Albrecht, Jidnyasa Ingale, Lifei Yang, Mike Hasenberg, Richard T. Wyatt, Karola Vorauer-Uhl, Klaus Überla, Vladimir Temchura

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Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model by James E. Voss, Raiees Andrabi, Laura E. McCoy, Natalia de Val, Roberta P. Fuller, Terrence Messmer, Ching-Yao Su, Devin Sok, Salar N. Khan, Fernando Garces, Laura K. Pritchard, Richard T. Wyatt, Andrew B. Ward, Max Crispin, Ian A. Wilson, Dennis R. Burton

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Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model by James E. Voss, Raiees Andrabi, Laura E. McCoy, Natalia de Val, Roberta P. Fuller, Terrence Messmer, Ching-Yao Su, Devin Sok, Salar N. Khan, Fernando Garces, Laura K. Pritchard, Richard T. Wyatt, Andrew B. Ward, Max Crispin, Ian A. Wilson, Dennis R. Burton

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Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization by K. Rachael Parks, Anna J. MacCamy, Josephine Trichka, Matthew Gray, Connor Weidle, Andrew J. Borst, Arineh Khechaduri, Brittany Takushi, Parul Agrawal, Javier Guenaga, Richard T. Wyatt, Rhea Coler, Michael Seaman, Celia LaBranche, David C. Montefiori, David Veesler, Marie Pancera, Andrew McGuire, Leonidas Stamatatos

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