Acute and durable effect of inhaled hypertonic saline on mucociliary clearance in adult asthma by William D. Bennett, Allison Burbank, Martha Almond, Jihong Wu, Agathe Ceppe, Michelle Hernandez, Richard C. Boucher, David B. Peden

Get full text

The adult cystic fibrosis airway microbiota is stable over time and infection type, and highly resilient to antibiotic treatment of exacerbations. by Anthony A Fodor, Erich R Klem, Deirdre F Gilpin, J Stuart Elborn, Richard C Boucher, Michael M Tunney, Matthew C Wolfgang

Get full text

Measuring airway surface liquid depth in ex vivo mouse airways by x-ray imaging for the assessment of cystic fibrosis airway therapies. by Kaye S Morgan, Martin Donnelley, David M Paganin, Andreas Fouras, Naoto Yagi, Yoshio Suzuki, Akihisa Takeuchi, Kentaro Uesugi, Richard C Boucher, David W Parsons, Karen K W Siu

Get full text

Effect of hypertonic saline on mucociliary clearance and clinical outcomes in chronic bronchitis by William D. Bennett, Ashley G. Henderson, Agathe Ceppe, Kirby L. Zeman, Jihong Wu, Christine Gladman, Fred Fuller, Stephen Gazda, Brian Button, Richard C. Boucher, Scott H. Donaldson

Get full text

Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children. by Marianne S Muhlebach, Bryan T Zorn, Charles R Esther, Joseph E Hatch, Conor P Murray, Lidija Turkovic, Sarath C Ranganathan, Richard C Boucher, Stephen M Stick, Matthew C Wolfgang

Get full text

A biophysical basis for mucus solids concentration as a candidate biomarker for airways disease. by David B Hill, Paula A Vasquez, John Mellnik, Scott A McKinley, Aaron Vose, Frank Mu, Ashley G Henderson, Scott H Donaldson, Neil E Alexis, Richard C Boucher, M Gregory Forest

Get full text

An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy by Gregg A. Duncan, Namho Kim, Yanerys Colon-Cortes, Jason Rodriguez, Marina Mazur, Susan E. Birket, Steven M. Rowe, Natalie E. West, Alessandra Livraghi-Butrico, Richard C. Boucher, Justin Hanes, George Aslanidi, Jung Soo Suk

Get full text

CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium. by Liqun Zhang, Brian Button, Sherif E Gabriel, Susan Burkett, Yu Yan, Mario H Skiadopoulos, Yan Li Dang, Leatrice N Vogel, Tristan McKay, April Mengos, Richard C Boucher, Peter L Collins, Raymond J Pickles

Get full text

Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells by Shunsuke Kamei, Haruka Fujikawa, Hirofumi Nohara, Keiko Ueno-Shuto, Kasumi Maruta, Ryunosuke Nakashima, Taisei Kawakami, Chizuru Matsumoto, Yuki Sakaguchi, Tomomi Ono, Mary Ann Suico, Richard C. Boucher, Dieter C. Gruenert, Toru Takeo, Naomi Nakagata, Jian-Dong Li, Hirofumi Kai, Tsuyoshi Shuto

Get full text

Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease by Aran Singanayagam, Joseph Footitt, Matthias Marczynski, Giorgia Radicioni, Michael T. Cross, Lydia J. Finney, Maria-Belen Trujillo-Torralbo, Maria Calderazzo, Jie Zhu, Julia Aniscenko, Thomas B. Clarke, Philip L. Molyneaux, Nathan W. Bartlett, Miriam F. Moffatt, William O. Cookson, Jadwiga Wedzicha, Christopher M. Evans, Richard C. Boucher, Mehmet Kesimer, Oliver Lieleg, Patrick Mallia, Sebastian L. Johnston

Get full text

SARS-CoV-2 variant of concern fitness and adaptation in primary human airway epithelia by Rita M. Meganck, Caitlin E. Edwards, Michael L. Mallory, Rhianna E. Lee, Hong Dang, Alexis B. Bailey, Jason A. Wykoff, Samuel C. Gallant, Deanna R. Zhu, Boyd L. Yount, Takafumi Kato, Kendall M. Shaffer, Satoko Nakano, Anne Marie Cawley, Vishwaraj Sontake, Jeremy R. Wang, Robert S. Hagan, Melissa B. Miller, Purushothama Rao Tata, Scott H. Randell, Longping V. Tse, Camille Ehre, Kenichi Okuda, Richard C. Boucher, Ralph S. Baric

Get full text

Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implications by Oisin F. McElvaney, Takanori Asakura, Suzanne L. Meinig, Jose L. Torres-Castillo, Robert S. Hagan, Claudie Gabillard, Mark P. Murphy, Leigh B. Thorne, Alain Borczuk, Emer P. Reeves, Ross E. Zumwalt, Yu Mikami, Tomas P. Carroll, Kenichi Okuda, Grace Hogan, Oliver J. McElvaney, Jennifer Clarke, Natalie L. McEvoy, Patrick W. Mallon, Cormac McCarthy, Ger Curley, Matthew C. Wolfgang, Richard C. Boucher, Noel G. McElvaney

Get full text

A Multitrait Locus Regulates Sarbecovirus Pathogenesis by Alexandra Schäfer, Sarah R. Leist, Lisa E. Gralinski, David R. Martinez, Emma S. Winkler, Kenichi Okuda, Padraig E. Hawkins, Kendra L. Gully, Rachel L. Graham, D. Trevor Scobey, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Jennifer F. Loome, Emily A. Madden, Elizabeth Anderson, Victoria K. Baxter, Sharon A. Taft-Benz, Mark R. Zweigart, Samantha R. May, Stephanie Dong, Matthew Clark, Darla R. Miller, Rachel M. Lynch, Mark T. Heise, Roland Tisch, Richard C. Boucher, Fernando Pardo Manuel de Villena, Stephanie A. Montgomery, Michael S. Diamond, Martin T. Ferris, Ralph S. Baric

Get full text

Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene by Jie Xu, Alessandra Livraghi-Butrico, Xia Hou, Carthic Rajagopalan, Jifeng Zhang, Jun Song, Hong Jiang, Hong-Guang Wei, Hui Wang, Mohamad Bouhamdan, Jinxue Ruan, Dongshan Yang, Yining Qiu, Youming Xie, Ronald Barrett, Sharon McClellan, Hongmei Mou, Qingtian Wu, Xuequn Chen, Troy D. Rogers, Kristen J. Wilkinson, Rodney C. Gilmore, Charles R. Esther Jr., Khalequz Zaman, Xiubin Liang, Michael Sobolic, Linda Hazlett, Kezhong Zhang, Raymond A. Frizzell, Martina Gentzsch, Wanda K. O’Neal, Barbara R. Grubb, Y. Eugene Chen, Richard C. Boucher, Fei Sun

Get full text

A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD by Katarina M. DiLillo, Katy C. Norman, Christine M. Freeman, Stephanie A. Christenson, Neil E. Alexis, Wayne H. Anderson, Igor Z. Barjaktarevic, R. Graham Barr, Alejandro P. Comellas, Eugene R. Bleecker, Richard C. Boucher, David J. Couper, Gerard J. Criner, Claire M. Doerschuk, J. Michael Wells, MeiLan K. Han, Eric A. Hoffman, Nadia N. Hansel, Annette T. Hastie, Robert J. Kaner, Jerry A. Krishnan, Wassim W. Labaki, Fernando J. Martinez, Deborah A. Meyers, Wanda K. O’Neal, Victor E. Ortega, Robert Paine, Stephen P. Peters, Prescott G. Woodruff, Christopher B. Cooper, Russell P. Bowler, Jeffrey L. Curtis, Kelly B. Arnold, SPIROMICS investigators

Get full text

Immunogenetics associated with severe coccidioidomycosis by Amy P. Hsu, Agnieszka Korzeniowska, Cynthia C. Aguilar, Jingwen Gu, Eric Karlins, Andrew J. Oler, Gang Chen, Glennys V. Reynoso, Joie Davis, Alexandria Chaput, Tao Peng, Ling Sun, Justin B. Lack, Derek J. Bays, Ethan R. Stewart, Sarah E. Waldman, Daniel A. Powell, Fariba M. Donovan, Jigar V. Desai, Nima Pouladi, Debra A. Long Priel, Daisuke Yamanaka, Sergio D. Rosenzweig, Julie E. Niemela, Jennifer Stoddard, Alexandra F. Freeman, Christa S. Zerbe, Douglas B. Kuhns, Yves A. Lussier, Kenneth N. Olivier, Richard C. Boucher, Heather D. Hickman, Jeffrey Frelinger, Joshua Fierer, Lisa F. Shubitz, Thomas L. Leto, George R. Thompson III, John N. Galgiani, Michail S. Lionakis, Steven M. Holland

Get full text