Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial by Sydes Matthew R, Parmar Mahesh KB, Mason Malcolm D, Clarke Noel W, Amos Claire, Anderson John, de Bono Johann, Dearnaley David P, Dwyer John, Green Charlene, Jovic Gordana, Ritchie Alastair WS, Russell J, Sanders Karen, Thalmann George, James Nicholas D

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