756 Assessment of the immune checkpoint landscape in head and neck squamous cell carcinoma by single-cell RNA sequencing and multispectral imaging by Lazar Vujanovic, Riyue Bao, Uma Duvvuri, Seungwon Kim, Robert Ferris, Stephan Lang, Aditi Kulkarni, Cornelius Kürten, Patricia Santos, Heath Skinner

Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response by Sean P. Korpela, Trista K. Hinz, Ayman Oweida, Jihye Kim, Jacob Calhoun, Robert Ferris, Raphael A. Nemenoff, Sana D. Karam, Eric T. Clambey, Lynn E. Heasley

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1003 TIM-3+ natural killer cell dysfunction is driven by galectin-9 in head and neck squamous cell carcinoma by Xin Zhang, Lazar Vujanovic, Riyue Bao, Robert Ferris, Tullia Bruno, Jennifer Anderson, Aditi Kulkarni, Hridesh Banerjee, Housaiyin Li, Juncheng Wang, Lidia Arantes, Lawrence P Kane

Reimagining HIV service delivery: the role of differentiated care from prevention to suppression by Anna Grimsrud, Helen Bygrave, Meg Doherty, Peter Ehrenkranz, Tom Ellman, Robert Ferris, Nathan Ford, Bactrin Killingo, Lynette Mabote, Tara Mansell, Annette Reinisch, Isaac Zulu, Linda‐Gail Bekker

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547 Reprogramming of type I interferon-responding tumor-reactive T lymphocytes associates with improved outcomes to neoadjuvant doublet immunotherapy in HNSCC by Lazar Vujanovic, Riyue Bao, Uma Duvvuri, Seungwon Kim, Robert Ferris, Aditi Kulkarni, Patricia Santos, Dan P Zandberg, Simon Chiosea, Housaiyin Li, Brian Isett, Joy Marion, Mark Kubik

536 Divergent cancer etiologies drive distinct B cell signatures and tertiary lymphoid structures in head and neck cancer by Tracy Tabib, Robert Lafyatis, Seungwon Kim, Robert Ferris, Ayana Ruffin, Angen Liu, Sayali Onkar, Sheryl Kunning, Caleb Lampenfeld, Irina Abecassis, Zengbiao Qi, Ryan Soose, Umamaheswar Duvvuri, Steffi Oesterrich

An individualized causal framework for learning intercellular communication networks that define microenvironments of individual tumors. by Xueer Chen, Lujia Chen, Cornelius H L Kürten, Fattaneh Jabbari, Lazar Vujanovic, Ying Ding, Binfeng Lu, Kevin Lu, Aditi Kulkarni, Tracy Tabib, Robert Lafyatis, Gregory F Cooper, Robert Ferris, Xinghua Lu

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Viral Transcript and Tumor Immune Microenvironment-Based Transcriptomic Profiling of HPV-Associated Head and Neck Squamous Cell Carcinoma Identifies Subtypes Associated with Progno... by Anastasiia Nikitina, Daria Kiriy, Andrey Tyshevich, Dmitry Tychinin, Zoya Antysheva, Anastasya Sobol, Vladimir Kushnarev, Nara Shin, Jessica H. Brown, James Lewis, Krystle A. Lang Kuhs, Robert Ferris, Lori Wirth, Nikita Kotlov, Daniel L. Faden

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Definitive local therapy to head and neck squamous cell carcinoma with distant metastasis by Steven Borson, Yongli Shuai, Barton F. Branstetter, Marci Lee Nilsen, Marion A. Hughes, Moon Fenton, Mark Kubik, Shaum Sridharan, David A. Clump, Heath D. Skinner, Jonas T. Johnson, Simion I. Chiosea, James Ohr, Umamaheswar Duvvuri, Seungwon Kim, Katie S. Traylor, Robert Ferris, Dan P. Zandberg

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Perspectives in immunotherapy: meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy) by Paolo A. Ascierto, James Brugarolas, Luigi Buonaguro, Lisa H. Butterfield, David Carbone, Bruno Daniele, Robert Ferris, Bernard A. Fox, Jérôme Galon, Cesare Gridelli, Howard L. Kaufman, Christopher A. Klebanoff, Ignacio Melero, Paul Nathan, Chrystal M. Paulos, Marco Ruella, Ryan Sullivan, Hassane Zarour, Igor Puzanov

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Perspectives in immunotherapy: meeting report from the immunotherapy bridge (December 2nd–3rd, 2020, Italy) by Paolo A. Ascierto, Carlo Bifulco, Fortunato Ciardiello, Sandra Demaria, Leisha A. Emens, Robert Ferris, Silvia C. Formenti, Jerome Galon, Samir N. Khleif, Tomas Kirchhoff, Jennifer McQuade, Kunle Odunsi, Akash Patnaik, Chrystal M. Paulos, Janis M. Taube, John Timmerman, Bernard A. Fox, Patrick Hwu, Igor Puzanov

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Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo by Shane D. Falcinelli, Jackson J. Peterson, Anne-Marie W. Turner, David Irlbeck, Jenna Read, Samuel L.M. Raines, Katherine S. James, Cameron Sutton, Anthony Sanchez, Ann Emery, Gavin Sampey, Robert Ferris, Brigitte Allard, Simon Ghofrani, Jennifer L. Kirchherr, Caroline Baker, JoAnn D. Kuruc, Cynthia L. Gay, Lindsey I. James, Guoxin Wu, Paul Zuck, Inmaculada Rioja, Rebecca C. Furze, Rab K. Prinjha, Bonnie J. Howell, Ronald Swanstrom, Edward P. Browne, Brian D. Strahl, Richard M. Dunham, Nancie M. Archin, David M. Margolis

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Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer by Aida Ferreiro-Iglesias, James D. McKay, Nicole Brenner, Shama Virani, Corina Lesseur, Valerie Gaborieau, Andy R. Ness, Rayjean J. Hung, Geoffrey Liu, Brenda Diergaarde, Andrew F. Olshan, Neil Hayes, Mark C. Weissler, Lea Schroeder, Noemi Bender, Michael Pawlita, Steve Thomas, Miranda Pring, Tom Dudding, Beatriz Kanterewicz, Robert Ferris, Sera Thomas, Yonathan Brhane, Virginia Díez-Obrero, Maja Milojevic, Karl Smith-Byrne, Daniela Mariosa, Mattias J. Johansson, Rolando Herrero, Stefania Boccia, Gabriella Cadoni, Martin Lacko, Ivana Holcátová, Wolfgang Ahrens, Pagona Lagiou, Areti Lagiou, Jerry Polesel, Lorenzo Simonato, Franco Merletti, Claire M. Healy, Bo T. Hansen, Mari Nygård, David I. Conway, Sylvia Wright, Tatiana V. Macfarlane, Max Robinson, Laia Alemany, Antonio Agudo, Ariana Znaor, Christopher I. Amos, Tim Waterboer, Paul Brennan

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