Insulin at 100 years – is rebalancing its action key to fighting obesity-related disease? by Gemma V. Brierley, Robert K. Semple

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Luminescent peptide tagging enables efficient screening for CRISPR-mediated knock-in in human induced pluripotent stem cells [version 3; peer review: 2 approved] by Ralitsa R. Madsen, Robert K. Semple

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Editorial: Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases? by Patrick C. Even, Sam Virtue, Nicholas M. Morton, Gilles Fromentin, Robert K. Semple, Robert K. Semple

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Case report: Allogeneic stem cell transplantation for type B insulin resistance by Thomas Ebert, Gerhard Behre, Gerhard Behre, Lorenz Weidhase, Vladan Vucinic, Cornelia Gewert, Cornelia Gewert, Robert K. Semple, Robert K. Semple, Robert K. Semple, Michael Stumvoll, Anke Tönjes

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Author Correction: Genotype-stratified treatment for monogenic insulin resistance: a systematic review by Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, ADA/EASD PMDI, Rebecca J. Brown

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Genotype-stratified treatment for monogenic insulin resistance: a systematic review by Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, ADA/EASD PMDI, Rebecca J. Brown

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Caenorhabditis elegans DAF-2 as a Model for Human Insulin Receptoropathies by David A. Bulger, Tetsunari Fukushige, Sijung Yun, Robert K. Semple, John A. Hanover, Michael W. Krause

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Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype. by Ralitsa R Madsen, Emily C Erickson, Oscar M Rueda, Xavier Robin, Carlos Caldas, Alex Toker, Robert K Semple, Bart Vanhaesebroeck

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Type B insulin resistance syndrome associated with connective tissue disease and psoriasis by Agnieszka Łebkowska, Anna Krentowska, Agnieszka Adamska, Danuta Lipińska, Beata Piasecka, Otylia Kowal-Bielecka, Maria Górska, Robert K Semple, Irina Kowalska

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Evaluation of human dermal fibroblasts directly reprogrammed to adipocyte-like cells as a metabolic disease model by Jian-Hua Chen, Kim Jee Goh, Nuno Rocha, Matthijs P. Groeneveld, Marina Minic, Timothy G. Barrett, David Savage, Robert K. Semple

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p53 Regulates Mitochondrial Dynamics in Vascular Smooth Muscle Cell Calcification by Kanchan Phadwal, Qi-Yu Tang, Ineke Luijten, Jin-Feng Zhao, Brendan Corcoran, Robert K. Semple, Ian G. Ganley, Vicky E. MacRae

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An expanded clinical spectrum of hypoinsulinaemic hypoketotic hypoglycaemia by Alena Welters, Sarah M Leiter, Nadine Bachmann, Carsten Bergmann, Henrike Hoermann, Eckhard Korsch, Thomas Meissner, Felicity Payne, Rachel Williams, Khalid Hussain, Robert K. Semple, Sebastian Kummer

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A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion by Jake P Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Sam Virtue, Stephen O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage

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Genome‐Wide Association Study of NAFLD Using Electronic Health Records by Cameron J. Fairfield, Thomas M. Drake, Riinu Pius, Andrew D. Bretherick, Archie Campbell, David W. Clark, Jonathan A. Fallowfield, Caroline Hayward, Neil C. Henderson, Peter K. Joshi, Nicholas L. Mills, David J. Porteous, Prakash Ramachandran, Robert K. Semple, Catherine A. Shaw, Cathie L.M. Sudlow, Paul R.H.J. Timmers, James F. Wilson, Stephen J. Wigmore, Ewen M. Harrison, Athina Spiliopoulou

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Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism by Benoit Bilanges, Samira Alliouachene, Wayne Pearce, Daniele Morelli, Gyorgy Szabadkai, Yuen-Li Chung, Gaëtan Chicanne, Colin Valet, Julia M. Hill, Peter J. Voshol, Lucy Collinson, Christopher Peddie, Khaled Ali, Essam Ghazaly, Vinothini Rajeeve, Georgios Trichas, Shankar Srinivas, Claire Chaussade, Rachel S. Salamon, Jonathan M. Backer, Cheryl L. Scudamore, Maria A. Whitehead, Erin P. Keaney, Leon O. Murphy, Robert K. Semple, Bernard Payrastre, Sharon A. Tooze, Bart Vanhaesebroeck

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Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression by Nuno Rocha, David A Bulger, Andrea Frontini, Hannah Titheradge, Sigrid Bjerge Gribsholt, Rachel Knox, Matthew Page, Julie Harris, Felicity Payne, Claire Adams, Alison Sleigh, John Crawford, Anette Prior Gjesing, Jette Bork-Jensen, Oluf Pedersen, Inês Barroso, Torben Hansen, Helen Cox, Mary Reilly, Alex Rossor, Rebecca J Brown, Simeon I Taylor, Duncan McHale, Martin Armstrong, Elif A Oral, Vladimir Saudek, Stephen O’Rahilly, Eamonn R Maher, Bjørn Richelsen, David B Savage, Robert K Semple

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A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. by J Brent Richards, Dawn Waterworth, Stephen O'Rahilly, Marie-France Hivert, Ruth J F Loos, John R B Perry, Toshiko Tanaka, Nicholas John Timpson, Robert K Semple, Nicole Soranzo, Kijoung Song, Nuno Rocha, Elin Grundberg, Josée Dupuis, Jose C Florez, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Robert Sladek, Yurii Aulchenko, David Evans, Gerard Waeber, Jeanette Erdmann, Mary-Susan Burnett, Naveed Sattar, Joseph Devaney, Christina Willenborg, Aroon Hingorani, Jaquelin C M Witteman, Peter Vollenweider, Beate Glaser, Christian Hengstenberg, Luigi Ferrucci, David Melzer, Klaus Stark, John Deanfield, Janina Winogradow, Martina Grassl, Alistair S Hall, Josephine M Egan, John R Thompson, Sally L Ricketts, Inke R König, Wibke Reinhard, Scott Grundy, H-Erich Wichmann, Phil Barter, Robert Mahley, Y Antero Kesaniemi, Daniel J Rader, Muredach P Reilly, Stephen E Epstein, Alexandre F R Stewart, Cornelia M Van Duijn, Heribert Schunkert, Keith Burling, Panos Deloukas, Tomi Pastinen, Nilesh J Samani, Ruth McPherson, George Davey Smith, Timothy M Frayling, Nicholas J Wareham, James B Meigs, Vincent Mooser, Tim D Spector, GIANT Consortium

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