The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence. by Jeroen H Nijwening, Ernst-Jan Geutjes, Rene Bernards, Roderick L Beijersbergen

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A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway. by Jasper Mullenders, Armida W M Fabius, Mandy Madiredjo, René Bernards, Roderick L Beijersbergen

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A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathways by Martin F. M. de Rooij, Yvonne J. Thus, Nathalie Swier, Roderick L. Beijersbergen, Steven T. Pals, Marcel Spaargaren

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A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing by Miguel Vizoso, Colin E. J. Pritchard, Lorenzo Bombardelli, Bram van den Broek, Paul Krimpenfort, Roderick L. Beijersbergen, Kees Jalink, Jacco van Rheenen

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Correction to: A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers by Tonći Šuštić, Sake van Wageningen, Evert Bosdriesz, Robert J. D. Reid, John Dittmar, Cor Lieftink, Roderick L. Beijersbergen, Lodewyk F. A. Wessels, Rodney Rothstein, René Bernards

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A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers by Tonći Šuštić, Sake van Wageningen, Evert Bosdriesz, Robert J. D. Reid, John Dittmar, Cor Lieftink, Roderick L. Beijersbergen, Lodewyk F. A. Wessels, Rodney Rothstein, René Bernards

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PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs by Anirudh Prahallad, Guus J.J.E. Heynen, Giovanni Germano, Stefan M. Willems, Bastiaan Evers, Loredana Vecchione, Valentina Gambino, Cor Lieftink, Roderick L. Beijersbergen, Federica Di Nicolantonio, Alberto Bardelli, Rene Bernards

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The Cancer SENESCopedia: A delineation of cancer cell senescence by Fleur Jochems, Bram Thijssen, Giulia De Conti, Robin Jansen, Ziva Pogacar, Kelvin Groot, Liqin Wang, Arnout Schepers, Cun Wang, Haojie Jin, Roderick L. Beijersbergen, Rodrigo Leite de Oliveira, Lodewyk F.A. Wessels, René Bernards

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Sustained activation of EGFR-ERK1/2 signaling limits the response to tigecycline-induced mitochondrial respiratory deficiency in liver cancerResearch in context by Yangyang Zhou, Siying Wang, Wei Wu, Jing Ling, Haoyu Li, Qi Jia, Jiaojiao Zheng, Xingling Zheng, Ruobing Yu, Qiangxin Wu, Yaoping Shi, Cor Lieftink, Roderick L. Beijersbergen, Shengxian Yuan, René Bernards, Haojie Jin, Wenxin Qin

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Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors by Vera E. van der Noord, Wanda van der Stel, Gijs Louwerens, Danielle Verhoeven, Hendrik J. Kuiken, Cor Lieftink, Melanie Grandits, Gerhard F. Ecker, Roderick L. Beijersbergen, Peter Bouwman, Sylvia E. Le Dévédec, Bob van de Water

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Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer by Yuchen Guo, Jun Wang, Bente Benedict, Chen Yang, Frank van Gemert, Xuhui Ma, Dongmei Gao, Hui Wang, Shu Zhang, Cor Lieftink, Roderick L. Beijersbergen, Hein te Riele, Xiaohang Qiao, Qiang Gao, Chong Sun, Wenxin Qin, René Bernards, Cun Wang

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Rational combination of SHP2 and mTOR inhibition for the treatment of hepatocellular carcinoma by Antonio Mulero‐Sánchez, Christel F. A. Ramirez, Aimée duChatinier, Hui Wang, Sofie J. I. Koomen, Ji‐Ying Song, Marnix H. P. deGroot, Cor Lieftink, Astrid Bosma, Artur Burylo, Olaf vanTellingen, Roderick L. Beijersbergen, Cun Wang, Leila Akkari, René Bernards, Sara Mainardi

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Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity. by Ziva Pogacar, Jackie L Johnson, Lenno Krenning, Giulia De Conti, Fleur Jochems, Cor Lieftink, Arno Velds, Leyma Wardak, Kelvin Groot, Arnout Schepers, Liqin Wang, Ji-Ying Song, Marieke van de Ven, Olaf van Tellingen, Rene H Medema, Roderick L Beijersbergen, Rene Bernards, Rodrigo Leite de Oliveira

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Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer by Joyce Y. Buikhuisen, Patricia M. Gomez Barila, Kate Cameron, Saskia J. E. Suijkerbuijk, Cor Lieftink, Simone di Franco, Ana Krotenberg Garcia, Rebeca Uceda Castro, Kristiaan J. Lenos, Lisanne E. Nijman, Arezo Torang, Ciro Longobardi, Joan H. de Jong, Daniëlle Dekker, Giorgio Stassi, Louis Vermeulen, Roderick L. Beijersbergen, Jacco van Rheenen, Stephan Huveneers, Jan Paul Medema

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Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors by Jinhyuk Bhin, Mariana Paes Dias, Ewa Gogola, Frank Rolfs, Sander R. Piersma, Roebi de Bruijn, Julian R. de Ruiter, Bram van den Broek, Alexandra A. Duarte, Wendy Sol, Ingrid van der Heijden, Christina Andronikou, Taina S. Kaiponen, Lara Bakker, Cor Lieftink, Ben Morris, Roderick L. Beijersbergen, Marieke van de Ven, Connie R. Jimenez, Lodewyk F.A. Wessels, Sven Rottenberg, Jos Jonkers

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Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis by Hanke L. Matlung, Liane Babes, Xi Wen Zhao, Michel van Houdt, Louise W. Treffers, Dieke J. van Rees, Katka Franke, Karin Schornagel, Paul Verkuijlen, Hans Janssen, Pasi Halonen, Cor Lieftink, Roderick L. Beijersbergen, Jeanette H.W. Leusen, Jaap J. Boelens, Ingrid Kuhnle, Jutte van der Werff Ten Bosch, Karl Seeger, Sergio Rutella, Daria Pagliara, Takashi Matozaki, Eiji Suzuki, Catharina Willemien Menke-van der Houven van Oordt, Robin van Bruggen, Dirk Roos, Rene A.W. van Lier, Taco W. Kuijpers, Paul Kubes, Timo K. van den Berg

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