Genetic and molecular basis of myeloid neoplasms at single cell resolution Bằng Rodriguez Meira, A

Single cell analysis of normal and leukemic hematopoiesis Bằng Povinelli, B, Rodriguez-Meira, A, Mead, A

TARGET-Seq: a protocol for high-sensitivity single-cell mutational analysis and parallel RNA sequencing Bằng Rodriguez-Meira, A, O'Sullivan, J, Rahman, H, Mead, AJ

Rapid emergence of chronic lymphocytic leukemia during JAK2 inhibitor therapy in a patient with myelofibrosis Bằng Sousos, N, Buck, G, Rodriguez-Meira, A, Norfo, R, Hamblin, A, Pezzella, F, Davies, J, Hublitz, P, Psaila, B, Mead, AJ

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors Bằng Neo, WH, Meng, Y, Rodriguez-Meira, A, Fadlullah, MZH, Booth, CAG, Azzoni, E, Thongjuea, S, de Bruijn, MFTR, Jacobsen, SEW, Mead, AJ, Lacaud, G

Unravelling intratumoral heterogeneity through high-sensitivity single-cell mutational analysis and parallel RNA sequencing Bằng Rodriguez-Meira, A, Buck, G, Clark, S, Povinelli, B, Alcolea, V, Louka, E, McGowan, S, Hamblin, A, Sousos, N, Barkas, N, Giustacchini, A, Psaila, B, Jacobsen, S, Thongjuea, S, Mead, A

Cell-Intrinsic Depletion of AML1-ETO-Positive Pre-Leukemic HSCs By Kras Activating Mutation Bằng Di Genua, C, Norfo, R, Rodriguez-Meira, A, Drissen, R, Booth, C, Povinelli, B, Repapi, E, Gray, N, Carrelha, J, Kettyle, L, Jamieson, L, Neo, W, Nerlov, C, Mead, A

C/EBPα and GATA-2 mutations induce bilineage acute erythroid leukemia through transformation of a neomorphic neutrophil-erythroid progenitor Bằng Di Genua, C, Valletta, S, Buono, M, Stoilova, B, Sweeney, C, Rodriguez-Meira, A, Grover, A, Meng, Y, Beveridge, R, Aboukhalil, Z, Karamitros, D, Belderbos, ME, Bystykh, L, Thongjuea, S, Vyas, P, Nerlov, C

Molecular and Functional Characterization of Disease-Propagating Stem Cells in Juvenile Myelomonocytic Leukemia Bằng Louka, E, Povinelli, B, Rodriguez-Meira, A, Buck, G, Hamblin, A, Booth, C, Roy, A, Elliott, N, Iskander, D, de La Fuente, J, Fordham, N, Obyrne, S, Inglott, S, Rao, A, Roberts, I, Mead, A

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation. Bằng Di Genua, C, Norfo, R, Rodriguez-Meira, A, Wen, W, Drissen, R, Booth, C, Povinelli, B, Repapi, E, Gray, N, Carrelha, J, Kettyle, L, Jamieson, L, Neo, W, Thongjuea, S, Nerlov, C, Mead, A

Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia Bằng Giustacchini, A, Thongjuea, S, Barkas, N, Woll, P, Povinelli, B, Booth, C, Sopp, P, Norfo, R, Rodriguez-Meira, A, Ashley, N, Jamieson, L, Vyas, P, Anderson, K, Segerstolpe, Å, Qian, H, Olsson-Strömberg, U, Mustjoki, S, Sandberg, R, Jacobsen, S, Mead, A

Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner Bằng Luis, TC, Barkas, N, Carrelha, J, Giustacchini, A, Mazzi, S, Norfo, R, Wu, B, Aliouat, A, Guerrero, JA, Rodriguez-Meira, A, Bouriez-Jones, T, Macaulay, IC, Jasztal, M, Zhu, G, Ni, H, Robson, MJ, Blakely, RD, Mead, AJ, Nerlov, C, Ghevaert, C, Jacobsen, SEW

Single-cell analyses reveal megakaryocyte-biased hematopoiesis in myelofibrosis and identify mutant clone-specific targets Bằng Psaila, B, Wang, G, Rodriguez-Meira, A, Li, R, Heuston, EF, Murphy, L, Yee, D, Hitchcock, IS, Sousos, N, O'Sullivan, J, Anderson, S, Senis, YA, Weinberg, OK, Calicchio, ML, NIH Intramural Sequencing Center, Iskander, D, Royston, D, Milojkovic, D, Roberts, I, Bodine, DM, Thongjuea, S, Mead, AJ

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia Bằng Louka, E, Povinelli, B, Rodriguez-Meira, A, Buck, G, Wen, WX, Wang, G, Sousos, N, Ashley, N, Hamblin, A, Booth, CAG, Roy, A, Elliott, N, Iskander, D, de la Fuente, J, Fordham, N, O’Byrne, S, Inglott, S, Norfo, R, Salio, M, Thongjuea, S, Rao, A, Roberts, I, Mead, AJ

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A Bằng Brierley, CK, Yip, BH, Orlando, G, Goyal, H, Wen, S, Wen, J, Levine, MF, Jakobsdottir, GM, Rodriguez-Meira, A, Adamo, A, Bashton, M, Hamblin, A, Clark, SA, O'Sullivan, J, Murphy, L, Olijnik, AA, Cotton, A, Narina, S, Pruett-Miller, SM, Enshaei, A, Harrison, C, Drummond, M, Knapper, S, Tefferi, A, Antony-Debré, I, Thongjuea, S, Wedge, DC, Constantinescu, S, Papaemmanuil, E, Psaila, B, Crispino, JD, Mead, AJ

Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution Bằng Rodriguez-Meira, A, Norfo, R, Wen, S, Chédeville, AL, Rahman, H, O'Sullivan, J, Wang, G, Louka, E, Kretzschmar, WW, Paterson, A, Brierley, C, Martin, J-E, Demeule, C, Bashton, M, Sousos, N, Moralli, D, Subha Meem, L, Carrelha, J, Wu, B, Hamblin, A, Guermouche, H, Pasquier, F, Marzac, C, Girodon, F, Vainchenker, W, Drummond, M, Harrison, C, Chapman, JR, Plo, I, Jacobsen, SEW, Psaila, B, Thongjuea, S, Antony-Debré, I, Mead, AJ

Tamoxifen for the treatment of myeloproliferative neoplasms: a phase II clinical trial and exploratory analysis Bằng Fang, Z, Corbizi Fattori, G, McKerrell, T, Boucher, RH, Jackson, A, Fletcher, RS, Forte, D, Martin, J-E, Fox, S, Roberts, J, Glover, R, Harris, E, Bridges, HR, Grassi, L, Rodriguez-Meira, A, Mead, AJ, Knapper, S, Ewing, J, Butt, NM, Jain, M, Francis, S, Clark, FJ, Coppell, J, McMullin, MF, Wadelin, F, Narayanan, S, Milojkovic, D, Drummond, MW, Sekhar, M, ElDaly, H, Hirst, J, Paramor, M, Baxter, EJ, Godfrey, AL, Harrison, CN, Méndez-Ferrer, S