Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric <i>MLL</i>-Rearranged Acute Lymphoblastic Leukemia by Mark Kerstjens, Patricia Garrido Castro, Sandra S. Pinhanços, Pauline Schneider, Priscilla Wander, Rob Pieters, Ronald W. Stam

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Trametinib inhibits RAS-mutant MLL-rearranged acute lymphoblastic leukemia at specific niche sites and reduces ERK phosphorylation in vivo by Mark Kerstjens, Sandra S. Pinhancos, Patricia Garrido Castro, Pauline Schneider, Priscilla Wander, Rob Pieters, Ronald W. Stam

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D-HPLC analysis of the entire FLT3 gene in MLL rearranged and hyperdiploid acute lymphoblastic leukemia by Ronald W. Stam, Monique L. den Boer, Pauline Schneider, Marrit Meier, H. Berna Beverloo, Rob Pieters

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Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia by Andrica C.H. de Vries, Ronald W. Stam, Christian P. Kratz, Martin Zenker, Charlotte M. Niemeyer, Marry M. van den Heuvel-Eibrink

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Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants by Emma M.C. Driessen, Eddy H.J. van Roon, Jill A.P. Spijkers-Hagelstein, Pauline Schneider, Paola de Lorenzo, Maria Grazia Valsecchi, Rob Pieters, Ronald W. Stam

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Selective inhibition of HDAC class IIA as therapeutic intervention for KMT2A-rearranged acute lymphoblastic leukemia by Tamara C. A. I. Verbeek, Kirsten S. Vrenken, Susan T. C. J. M. Arentsen-Peters, Patricia Garrido Castro, Marieke van de Ven, Olaf van Tellingen, Rob Pieters, Ronald W. Stam

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NUTM1 is a recurrent fusion gene partner in B-cell precursor acute lymphoblastic leukemia associated with increased expression of genes on chromosome band 10p12.31-12.2 by Femke M. Hormann, Alex Q. Hoogkamer, H. Berna Beverloo, Aurélie Boeree, Ilse Dingjan, Moniek M. Wattel, Ronald W. Stam, Gabriele Escherich, Rob Pieters, Monique L. den Boer, Judith M. Boer

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Decitabine mildly attenuates MLL‐rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo‐sensitizer by Pauline Schneider, Patricia Garrido Castro, Sandra M. Pinhanços, Mark Kerstjens, Eddy H. vanRoon, Anke H.W. Essing, M. Emmy M. Dolman, Jan J. Molenaar, Rob Pieters, Ronald W. Stam

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Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemia by Diana Schotte, Ellen A.M. Lange-Turenhout, Dominique J.P.M. Stumpel, Ronald W. Stam, Jessica G.C.A.M. Buijs-Gladdines, Jules P.P. Meijerink, Rob Pieters, Monique L. Den Boer

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Clinical and molecular genetic characterization of wild-type MLL infant acute lymphoblastic leukemia identifies few recurrent abnormalities by Marieke H. van der Linden, Judith M. Boer, Pauline Schneider, Merel Willekes, Lidija Seslija, Paola De Lorenzo, Maria Grazia Valsecchi, Giovanni Cazzaniga, Andrea Biondi, Monique L. den Boer, Rob Pieters, Ronald W. Stam

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Role of mutation independent constitutive activation of FLT3 in juvenile myelomonocytic leukemia by Andrica C.H. de Vries, Ronald W. Stam, Pauline Schneider, Charlotte M. Niemeyer, Elisabeth R. van Wering, Oskar A. Haas, Christian P. Kratz, Monique L. den Boer, Rob Pieters, Marry M. van den Heuvel-Eibrink

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Combining CRISPR-Cas9 and TCR exchange to generate a safe and efficient cord blood-derived T cell product for pediatric relapsed AML by Zsolt Sebestyen, Jürgen Kuball, Maud Plantinga, Anja Krippner-Heidenreich, S Nierkens, Ester Dunnebach, Vania Lo Presti, Olaf T Heidenreich, Angelo Meringa, Alice van Velzen, Aida Valera Moreira, Ronald W Stam, Rishi S Kotecha, Annelisa Cornel, Niek P van Til

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Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia by Pauline Schneider, Nicholas T. Crump, Susan T.C.J.M. Arentsen-Peters, Alastair L. Smith, Rico Hagelaar, Fabienne R.S. Adriaanse, Romy S. Bos, Anja de Jong, Stefan Nierkens, Bianca Koopmans, Thomas A. Milne, Rob Pieters, Ronald W. Stam

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High-Throughput Drug Library Screening in Primary <i>KMT2A</i>-Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling by Priscilla Wander, Susan T. C. J. M. Arentsen-Peters, Kirsten S. Vrenken, Sandra Mimoso Pinhanҫos, Bianca Koopmans, M. Emmy M. Dolman, Luke Jones, Patricia Garrido Castro, Pauline Schneider, Mark Kerstjens, Jan J. Molenaar, Rob Pieters, Christian Michel Zwaan, Ronald W. Stam

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Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis by Antonio Agraz-Doblas, Clara Bueno, Rachael Bashford-Rogers, Anindita Roy, Pauline Schneider, Michela Bardini, Paola Ballerini, Gianni Cazzaniga, Thaidy Moreno, Carlos Revilla, Marta Gut, Maria G. Valsecchi, Irene Roberts, Rob Pieters, Paola De Lorenzo, Ignacio Varela, Pablo Menendez, Ronald W. Stam

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The clinical and biological characteristics of NUP98-KDM5A in pediatric acute myeloid leukemia by Sanne Noort, Priscilla Wander, Todd A. Alonzo, Jenny Smith, Rhonda E. Ries, Robert B. Gerbing, M. Emmy M. Dolman, Franco Locatelli, Dirk Reinhardt, Andre Baruchel, Jan Stary, Jan J. Molenaar, Ronald W. Stam, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan, Soheil Meshinchi

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Integrative single‐cell expression and functional studies unravels a sensitization to cytarabine‐based chemotherapy through HIF pathway inhibition in AML leukemia stem cells by Talia Velasco‐Hernandez, Juan L. Trincado, Meritxell Vinyoles, Adria Closa, Alba Martínez‐Moreno, Francisco Gutiérrez‐Agüera, Oscar Molina, Virginia C. Rodríguez‐Cortez, Pau Ximeno‐Parpal, Narcís Fernández‐Fuentes, Paolo Petazzi, Sergi Beneyto‐Calabuig, Lars Velten, Paola Romecin, Raquel Casquero, Fernando Abollo‐Jiménez, Rafael D. de laGuardia, Patricia Lorden, Alex Bataller, Hélène Lapillonne, Ronald W. Stam, Susana Vives, Montserrat Torrebadell, Jose L. Fuster, Clara Bueno, Jean‐Emmanuel Sarry, Eduardo Eyras, Holger Heyn, Pablo Menéndez

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