Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations by Bull, K, Rimmer, A, Siggs, O, Miosge, L, Roots, C, Enders, A, Bertram, E, Crockford, T, Whittle, B, Potter, P, Simon, M, Mallon, A, Brown, S, Beutler, B, Goodnow, C, Lunter, G, Cornall, R

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A. by Bergmann, H, Yabas, M, Short, A, Miosge, L, Barthel, N, Teh, C, Roots, C, Bull, K, Jeelall, Y, Horikawa, K, Whittle, B, Balakishnan, B, Sjollema, G, Bertram, E, Mackay, F, Rimmer, A, Cornall, R, Field, M, Andrews, T, Goodnow, C, Enders, A

MUTATIONS IN THE INTRAMEMBRANE ENDOPEPTIDASE SPPL2A AFFECT HUMORAL IMMUNITY AND B-CELL SURVIVAL BY REDUCING SURFACE BCR AND BAFF-R EXPRESSION AND AFFECTING CD74 METABOLISM by Bergmann, H, Yabas, M, Short, A, Miosge, L, Barthel, N, Teh, C, Roots, C, Bull, K, Jeelall, Y, Horikawa, K, Whittle, B, Balakishnan, B, Sjollema, G, Bertram, E, Mackay, F, Rimmer, A, Cornall, R, Field, M, Andrews, D, Goodnow, C, Enders, A