Target-based vs. phenotypic screenings in Leishmania drug discovery: A marriage of convenience or a dialogue of the deaf? by Rosa M. Reguera, Estefanía Calvo-Álvarez, Raquel Álvarez-Velilla, Rafael Balaña-Fouce

Get full text

Deletion study of DNA topoisomerase IB from Leishmania donovani: searching for a minimal functional heterodimer. by Rosario Díaz González, Yolanda Pérez Pertejo, David Ordóñez, Rafael Balaña-Fouce, Rosa M Reguera

Get full text

Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery by Rafael Balaña-Fouce, Raquel Álvarez-Velilla, Christopher Fernández-Prada, Carlos García-Estrada, Rosa M. Reguera

Get full text

Miltefosine and Nifuratel Combination: A Promising Therapy for the Treatment of <i>Leishmania donovani</i> Visceral Leishmaniasis by Estela Melcon-Fernandez, Giulio Galli, Carlos García-Estrada, Rafael Balaña-Fouce, Rosa M. Reguera, Yolanda Pérez-Pertejo

Get full text

Synthesis of Marine α-Methoxylated Fatty Acid Analogs that Effectively Inhibit the Topoisomerase IB from Leishmania donovani with a Mechanism Different from that of Camptothecin by Rosa M. Reguera, Christopher F. Prada, Raquel Alvarez-Velilla, Nashbly Montano, Néstor M. Carballeira, Rafael Balaña-Fouce

Get full text

Polyamine Metabolism for Drug Intervention in Trypanosomatids by Yolanda Pérez-Pertejo, Carlos García-Estrada, María Martínez-Valladares, Sankaranarayanan Murugesan, Rosa M. Reguera, Rafael Balaña-Fouce

Get full text

Identification and characterization of the regions involved in the nuclear translocation of the heterodimeric leishmanial DNA topoisomerase IB. by Christopher F Prada, Raquel Álvarez-Velilla, Rosario Díaz-Gozález, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M Reguera

Get full text

First evidence of intraclonal genetic exchange in trypanosomatids using two Leishmania infantum fluorescent transgenic clones. by Estefanía Calvo-Álvarez, Raquel Álvarez-Velilla, Maribel Jiménez, Ricardo Molina, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M Reguera

Get full text

Correction: First Evidence of Intraclonal Genetic Exchange in Trypanosomatids Using Two Leishmania infantum Fluorescent Transgenic Clones. by Estefanía Calvo-Álvarez, Raquel Álvarez-Velilla, Maribel Jiménez, Ricardo Molina, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Rosa M Reguera

Get full text

Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum by Camino Gutiérrez-Corbo, Raquel Álvarez-Velilla, Rosa M. Reguera, Carlos García-Estrada, Mark Cushman, Rafael Balaña-Fouce, Yolanda Pérez-Pertejo

Get full text

Antiparasitic effect of synthetic aromathecins on Leishmania infantum by Rosa M. Reguera, Raquel Álvarez-Velilla, Bárbara Domínguez-Asenjo, Camino Gutiérrez-Corbo, Rafael Balaña-Fouce, Mark Cushman, Yolanda Pérez-Pertejo

Get full text

Reproduction in Trypanosomatids: Past and Present by Camino Gutiérrez-Corbo, Bárbara Domínguez-Asenjo, María Martínez-Valladares, Yolanda Pérez-Pertejo, Carlos García-Estrada, Rafael Balaña-Fouce, Rosa M. Reguera

Get full text

Axenic interspecies and intraclonal hybrid formation in Leishmania: Successful crossings between visceral and cutaneous strains by Camino Gutiérrez-Corbo, Bárbara Domínguez-Asenjo, Yolanda Pérez-Pertejo, Carlos García-Estrada, Felio J Bello, Rafael Balaña-Fouce, Rosa M. Reguera

Get full text

Further Investigations of Nitroheterocyclic Compounds as Potential Antikinetoplastid Drug Candidates by Carlos García-Estrada, Yolanda Pérez-Pertejo, Bárbara Domínguez-Asenjo, Vanderlan Nogueira Holanda, Sankaranarayanan Murugesan, María Martínez-Valladares, Rafael Balaña-Fouce, Rosa M. Reguera

Get full text

In Vitro and Ex Vivo Synergistic Effect of Pyrvinium Pamoate Combined with Miltefosine and Paromomycin against <i>Leishmania</i> by Estela Melcón-Fernández, Giulio Galli, Rafael Balaña-Fouce, Nerea García-Fernández, María Martínez-Valladares, Rosa M. Reguera, Carlos García-Estrada, Yolanda Pérez-Pertejo

Get full text

Characterization of the Gene Encoding S-adenosyl-L-methionine (AdoMet) Synthetase in <i>Penicillium chrysogenum</i>; Role in Secondary Metabolism and Penicillin Production by Rebeca Domínguez-Santos, Katarina Kosalková, Isabel-Clara Sánchez-Orejas, Carlos Barreiro, Yolanda Pérez-Pertejo, Rosa M. Reguera, Rafael Balaña-Fouce, Carlos García-Estrada

Get full text

Hybrid Quinolinyl Phosphonates as Heterocyclic Carboxylate Isosteres: Synthesis and Biological Evaluation against Topoisomerase 1B (TOP1B) by Asier Selas, María Fuertes, Estela Melcón-Fernández, Yolanda Pérez-Pertejo, Rosa M. Reguera, Rafael Balaña-Fouce, Birgitta R. Knudsen, Francisco Palacios, Concepcion Alonso

Get full text

Antileishmanial Effect of 1,5- and 1,8-Substituted Fused Naphthyridines by Estela Melcón-Fernandez, Endika Martín-Encinas, Francisco Palacios, Gulio Galli, Rosa M. Reguera, María Martínez-Valladares, Rafael Balaña-Fouce, Concepción Alonso, Yolanda Pérez-Pertejo

Get full text

Infrared fluorescent imaging as a potent tool for in vitro, ex vivo and in vivo models of visceral leishmaniasis. by Estefanía Calvo-Álvarez, Kostantinos Stamatakis, Carmen Punzón, Raquel Álvarez-Velilla, Ana Tejería, José Miguel Escudero-Martínez, Yolanda Pérez-Pertejo, Manuel Fresno, Rafael Balaña-Fouce, Rosa M Reguera

Get full text

Resistance to Experimental Visceral Leishmaniasis in Mice Infected With Leishmania infantum Requires Batf3 by Manuel Soto, Laura Ramírez, José Carlos Solana, Emma C. L. Cook, Elena Hernández-García, Sara Charro-Zanca, Ana Redondo-Urzainqui, Rosa M. Reguera, Rafael Balaña-Fouce, Salvador Iborra

Get full text