Epigenetic regulators and their impact on therapy in acute myeloid leukemia by Friederike Pastore, Ross L. Levine

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Next-generation sequencing in the diagnosis and minimal residual disease assessment of acute myeloid leukemia by Ross L. Levine, Peter J.M. Valk

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Development of a customizable mouse backbone spectral flow cytometry panel to delineate immune cell populations in normal and tumor tissues by Ana Leda F. Longhini, Inés Fernández-Maestre, Inés Fernández-Maestre, Margaret C. Kennedy, Margaret C. Kennedy, Matthew G. Wereski, Shoron Mowla, Wenbin Xiao, Wenbin Xiao, Wenbin Xiao, Scott W. Lowe, Scott W. Lowe, Ross L. Levine, Ross L. Levine, Ross L. Levine, Rui Gardner

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ETV6-ABL1-positive “chronic myeloid leukemia”: clinical and molecular response to tyrosine kinase inhibition by Fabiana Perna, Omar Abdel-Wahab, Ross L. Levine, Suresh C. Jhanwar, Kazunori Imada, Stephen D. Nimer

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Inhibition of the mutated c-KIT kinase in AML1-ETO–positive leukemia cells restores sensitivity to PARP inhibitor by Margaret Nieborowska-Skorska, Elisabeth M. Paietta, Ross L. Levine, Hugo F. Fernandez, Martin S. Tallman, Mark R. Litzow, Tomasz Skorski

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Genetic analysis of five children with essential thrombocytosis identified mutations in cancer-associated genes with roles in transcriptional regulation by Nicole Kucine, Aaron D. Viny, Raajit Rampal, Michael Berger, Nicholas Socci, Agnes Viale, James B. Bussel, Ross L. Levine, Franck Rapaport

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Comparative Mutational Profiling of Hematopoietic Progenitor Cells and Circulating Endothelial Cells (CECs) in Patients with Primary Myelofibrosis by Mirko Farina, Simona Bernardi, Nicola Polverelli, Mariella D’Adda, Michele Malagola, Katia Bosio, Federica Re, Camillo Almici, Andrew Dunbar, Ross L. Levine, Domenico Russo

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Challenges and approaches to implementing master/basket trials in oncology by Amy Burd, Richard L. Schilsky, John C. Byrd, Ross L. Levine, Vassiliki A. Papadimitrakopoulou, Roy S. Herbst, Mary W. Redman, Brian J. Druker, David R. Gandara

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Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis. by Serena De Vita, Rebekka K Schneider, Michael Garcia, Jenna Wood, Mathilde Gavillet, Benjamin L Ebert, Alexander Gerbaulet, Axel Roers, Ross L Levine, Ann Mullally, David A Williams

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Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia by Alan H. Shih, Stephen S. Chung, Emily K. Dolezal, Su-Jiang Zhang, Omar I. Abdel-Wahab, Christopher Y. Park, Stephen D. Nimer, Ross L. Levine, Virginia M. Klimek

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Mathematical modeling reveals alternative JAK inhibitor treatment in myeloproliferative neoplasms by Kaitlyn Shank, Andrew Dunbar, Priya Koppikar, Maria Kleppe, Julie Teruya-Feldstein, Isabelle Csete, Neha Bhagwat, Matthew Keller, Outi Kilpivaara, Franziska Michor, Ross L. Levine, Laura de Vargas Roditi

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LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone by Jonas S. Jutzi, Maria Kleppe, Jennifer Dias, Hans Felix Staehle, Kaitlyn Shank, Julie Teruya-Feldstein, Sudheer Madan Mohan Gambheer, Christine Dierks, Hugh Y. Rienhoff, Jr, Ross L. Levine, Heike L. Pahl

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The Polycomb Group Protein L3MBTL1 Represses a SMAD5-Mediated Hematopoietic Transcriptional Program in Human Pluripotent Stem Cells by Fabiana Perna, Ly P. Vu, Maria Themeli, Sonja Kriks, Ruben Hoya-Arias, Raya Khanin, Todd Hricik, Jorge Mansilla-Soto, Eirini P. Papapetrou, Ross L. Levine, Lorenz Studer, Michel Sadelain, Stephen D. Nimer

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S125: NON-GENETIC RESISTANCE TO MENIN INHIBITION IN AML IS REVERSIBLE BY PERTURBATION OF KAT6A by Florian Perner, Homa Rahnamoun, Daniela V. Wenge, Yijun Xiong, Athina Apazidis, Disha Anand, Charlie Hatton, Yanhe Wen, Shengqing Gu, X Shirley Liu, Wenbin Xiao, Sheng F. Cai, Ross L. Levine, Gerard M. Mcgeehan, Scott A. Armstrong

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Extramedullary acute myeloid leukemia presenting in young adults demonstrates sensitivity to high-dose anthracycline: a subset analysis from ECOG-ACRIN 1900 by Hugo F. Fernandez, Zhuoxin Sun, Mark R. Litzow, Selina M. Luger, Elisabeth Paietta, Janis Racevskis, Ross L. Levine, Jay P. Patel, Omar Abdel-Wahab, Rhett P. Ketterling, Gordon W. Dewald, John M. Bennett, Jacob M. Rowe, Hillard M. Lazarus, Martin S. Tallman

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Hsp90 inhibition disrupts JAK-STAT signaling and leads to reductions in splenomegaly in patients with myeloproliferative neoplasms by Gabriela S. Hobbs, Amritha Varshini Hanasoge Somasundara, Maria Kleppe, Rivka Litvin, Maria Arcila, Jihae Ahn, Anna Sophia McKenney, Kristina Knapp, Ryan Ptashkin, Howard Weinstein, Murk-Hein Heinemann, Jasmine Francis, Suzanne Chanel, Ellin Berman, Michael Mauro, Martin S. Tallman, Mark L. Heaney, Ross L. Levine, Raajit K. Rampal

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Developing a membrane-proximal CD33-targeting CAR T cell by Jaap Jan Boelens, Renier J Brentjens, Young Park, Ruby Freeman, Sanam Shahid, Abdul G Khan, Serena C Mathew, Sydney Souness, Erin R Burns, Jasmine S Um, Kento Tanaka, Winson Cai, Sarah Yoo, Andrew Dunbar, Devin McAvoy, Kinga K Hosszu, Ross L Levine, Ivo C Lorenz, Anthony F Daniyan

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Mutational correlates of response to hypomethylating agent therapy in acute myeloid leukemia by Catherine C. Coombs, David A. Sallman, Sean M. Devlin, Shweta Dixit, Abhinita Mohanty, Kristina Knapp, Najla H. Al Ali, Jeffrey E. Lancet, Alan F. List, Rami S. Komrokji, Eric Padron, Maria E. Arcila, Virginia M. Klimek, Marcel R. M. van den Brink, Martin S. Tallman, Ross L. Levine, Raajit K. Rampal, Franck Rapaport

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Therapy-related acute lymphoblastic leukemia is a distinct entity with adverse genetic features and clinical outcomes by Caner Saygin, Ashwin Kishtagari, Ryan D. Cassaday, Natalie Reizine, Ilana Yurkiewicz, Michaela Liedtke, Wendy Stock, Richard A. Larson, Ross L. Levine, Martin S. Tallman, Jae H. Park, Cassandra Kerr, Bartlomiej Przychodzen, Mikkael A. Sekeres, Matt E. Kalaycio, Hetty E. Carraway, Betty K. Hamilton, Ronald Sobecks, Aaron Gerds, Sudipto Mukherjee, Aziz Nazha, Jaroslaw P. Maciejewski, Anjali S. Advani

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Loss of plasmacytoid dendritic cell differentiation is highly predictive for post-induction measurable residual disease and inferior outcomes in acute myeloid leukemia by Wenbin Xiao, Aaron D. Goldberg, Christopher A. Famulare, Sean M. Devlin, Nghia T. Nguyen, Sinnifer Sim, Charlene C. Kabel, Minal A. Patel, Erin M. McGovern, Akshar Patel, Jessica Schulman, Andrew J. Dunbar, Zachary D. Epstein-Peterson, Kamal N. Menghrajani, Bartlomiej M. Getta, Sheng F. Cai, Mark B. Geyer, Jacob L. Glass, Justin Taylor, Aaron D. Viny, Ross L. Levine, Yanming Zhang, Sergio A. Giralt, Virginia Klimek, Martin S. Tallman, Mikhail Roshal

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