Mutation accumulation in mtDNA of cancers resembles mutagenesis in normal stem cells by Freek Manders, Jip van Dinter, Ruben van Boxtel

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Protocol to create isogenic disease models from adult stem cell-derived organoids using next-generation CRISPR tools by Martina Celotti, Lucca L.M. Derks, Johan van Es, Ruben van Boxtel, Hans Clevers, Maarten H. Geurts

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Transcriptomic and Epigenomic Profiling of Histone Deacetylase Inhibitor Treatment Reveals Distinct Gene Regulation Profiles Leading to Impaired Neutrophil Development by Anita M.A.P. Govers, Caroline R.M. Wiggers, Ruben van Boxtel, Michal Mokry, Edward E.S. Nieuwenhuis, Menno P. Creyghton, Marije Bartels, Paul J. Coffer

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Evaluating offspring Genomic and Epigenomic alterations after prenatal exposure to Cancer treatment In Pregnancy (GE-CIP): a multicentric observational study by Lode Godderis, Bernard Thienpont, Koenraad Devriendt, Frédéric Amant, Vera Wolters, Liesbeth Lenaerts, Kristel Van Calsteren, Thierry Voet, Ilana Struys, Carolina Velázquez, Heidi Segers, Ruben van Boxtel

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Genome‐wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling by Astrid Eijkelenboom, Michal Mokry, Elzo de Wit, Lydia M Smits, Paulien E Polderman, Miranda H van Triest, Ruben van Boxtel, Almut Schulze, Wouter de Laat, Edwin Cuppen, Boudewijn M T Burgering

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Protocol for genome-wide analysis of somatic variants at single-cell resolution using primary template-directed DNA amplification by Lucca L.M. Derks, Anaïs J.C.N. van Leeuwen, Alexander S. Steemers, Laurianne Trabut, Markus J. van Roosmalen, Vera M. Poort, Rico Hagelaar, Mark Verheul, Sjors Middelkamp, Ruben van Boxtel

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Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA by Daan M. K. van Soest, Paulien E. Polderman, Wytze T. F. den Toom, Janneke P. Keijer, Markus J. van Roosmalen, Tim M. F. Leyten, Johannes Lehmann, Susan Zwakenberg, Sasha De Henau, Ruben van Boxtel, Boudewijn M. T. Burgering, Tobias B. Dansen

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Single‐cell RNA sequencing of pediatric Hodgkin lymphoma to study the inhibition of T cell subtypes by Jurrian K. deKanter, Alexander S. Steemers, Diego Montiel González, Ravian L. vanIneveld, Catharina Blijleven, Niels Groenen, Laurianne Trabut, Marijn A. Scheijde‐Vermeulen, Liset Westera, Auke Beishuizen, Anne C. Rios, Frank C. P. Holstege, Arianne M. Brandsma, Thanasis Margaritis, Ruben vanBoxtel, Friederike Meyer‐Wentrup

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Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms by Eline J. M. Bertrums, Jurrian K. de Kanter, Lucca L. M. Derks, Mark Verheul, Laurianne Trabut, Markus J. van Roosmalen, Henrik Hasle, Evangelia Antoniou, Dirk Reinhardt, Michael N. Dworzak, Nora Mühlegger, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan, Bianca F. Goemans, Ruben van Boxtel

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One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids by Maarten H. Geurts, Shashank Gandhi, Matteo G. Boretto, Ninouk Akkerman, Lucca L. M. Derks, Gijs van Son, Martina Celotti, Sarina Harshuk-Shabso, Flavia Peci, Harry Begthel, Delilah Hendriks, Paul Schürmann, Amanda Andersson-Rolf, Susana M. Chuva de Sousa Lopes, Johan H. van Es, Ruben van Boxtel, Hans Clevers

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Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51 by Anne Margriet Heijink, Colin Stok, David Porubsky, Eleni Maria Manolika, Jurrian K. de Kanter, Yannick P. Kok, Marieke Everts, H. Rudolf de Boer, Anastasia Audrey, Femke J. Bakker, Elles Wierenga, Marcel Tijsterman, Victor Guryev, Diana C. J. Spierings, Puck Knipscheer, Ruben van Boxtel, Arnab Ray Chaudhuri, Peter M. Lansdorp, Marcel A. T. M. van Vugt

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Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes by Michael T Meister, Marian J A Groot Koerkamp, Terezinha de Souza, Willemijn B Breunis, Ewa Frazer‐Mendelewska, Mariël Brok, Jeff DeMartino, Freek Manders, Camilla Calandrini, Hinri H D Kerstens, Alex Janse, M Emmy M Dolman, Selma Eising, Karin P S Langenberg, Marc van Tuil, Rutger R G Knops, Sheila Terwisscha van Scheltinga, Laura S Hiemcke‐Jiwa, Uta Flucke, Johannes H M Merks, Max M van Noesel, Bastiaan B J Tops, Jayne Y Hehir‐Kwa, Patrick Kemmeren, Jan J Molenaar, Marc van de Wetering, Ruben van Boxtel, Jarno Drost, Frank C P Holstege

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