Hypo, Hyper, or Combo: new paradigm for treatment of acute myeloid leukemia in older people by Gunnar Juliusson, Martin Höglund, Sören Lehmann

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Ultra-sensitive monitoring of leukemia patients using superRCA mutation detection assays by Lei Chen, Anna Eriksson, Simone Weström, Tatjana Pandzic, Sören Lehmann, Lucia Cavelier, Ulf Landegren

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A critical appraisal of tools available for monitoring epigenetic changes in clinical samples from patients with myeloid malignancies by Kirsten Grønbæk, Carsten Müller-Tidow, Giovanni Perini, Sören Lehmann, Marianne Bach Treppendahl, Ken Mills, Christoph Plass, Brigitte Schlegelberger

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High-throughput mutational screening adds clinically important information in myelodysplastic syndromes and secondary or therapy-related acute myeloid leukemia by Mohsen Karimi, Christer Nilsson, Marios Dimitriou, Monika Jansson, Hans Matsson, Per Unneberg, Sören Lehmann, Juha Kere, Eva Hellström-Lindberg

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Selective lysis of acute myeloid leukemia cells by CD34/CD3 bispecific antibody through the activation of γδ T-cells by Faisal Al Agrafi, Ahmed Gaballa, Paula Hahn, Lucas C. M. Arruda, Adrian C. Jaramillo, Maartje Witsen, Sören Lehmann, Björn Önfelt, Michael Uhlin, Arwen Stikvoort

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Combinatorial molecule screening identified a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells by Simon Hultmark, Aurélie Baudet, Ludwig Schmiderer, Pavan Prabhala, Sara Palma-Tortosa, Carl Sandén, Thoas Fioretos, Rajkumar Sasidharan, Christer Larsson, Sören Lehmann, Gunnar Juliusson, Fredrik Ek, Mattias Magnusson

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S136: ANALYSIS OF FACTORS ASSOCIATED WITH LONG-TERM SURVIVAL IN A LARGE ACUTE PROMYELOCYTIC LEUKEMIA (APL) PATIENT COHORT: A HARMONY ALLIANCE STUDY by Luca Guarnera, Soren Lehmann, Konstanze Döhner, Hartmut Döhner, Gert Ossenkoppele, Nigel Russell, Richard Dillon, Uwe Platzbecker, Marco Vignetti, Edoardo la Sala, Angela Villaverde, Laura Tur, Jesus Hernández Rivas, Maria Teresa Voso

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Characterization of therapy-related acute myeloid leukemia: increasing incidence and prognostic implications by Christer Nilsson, Fredrika Linde, Erik Hulegårdh, Hege Garelius, Vladimir Lazarevic, Petar Antunovic, Jörg Cammenga, Stefan Deneberg, Anna Eriksson, Martin Jädersten, Cecilia Kämpe Björkvall, Lars Möllgård, Lovisa Wennström, Emma Ölander, Martin Höglund, Gunnar Juliusson, Sören Lehmann

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A risk score based on real-world data to predict early death in acute promyelocytic leukemia by Albin Österroos, Tânia Maia, Anna Eriksson, Martin Jädersten, Vladimir Lazarevic, Lovisa Wennström, Petar Antunovic, Jörg Cammenga, Stefan Deneberg, Fryderyk Lorenz, Lars Möllgård, Bertil Uggla, Emma Ölander, Eliana Aguiar, Fernanda Trigo, Martin Höglund, Gunnar Juliusson, Sören Lehmann

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Proteome-wide CETSA reveals diverse apoptosis-inducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery by Anderson Daniel Ramos, Ying Yu Liang, Olga Surova, Smaranda Bacanu, Marc-Antoine Gerault, Tamoghna Mandal, Sophia Ceder, Anette Langebäck, Albin Österroos, George A. Ward, Jonas Bergh, Klas G. Wiman, Sören Lehmann, Nayana Prabhu, Sara Lööf, Pär Nordlund

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A novel CD34-specific T-cell engager efficiently depletes acute myeloid leukemia and leukemic stem cells <i>in vitro</i> and <i>in vivo</i> by Lucas C. M. Arruda, Arwen Stikvoort, Melanie Lambert, Liqing Jin, Laura Sanchez Rivera, Renato M. P. Alves, Tales Rocha de Moura, Carsten Mim, Sören Lehmann, Rebecca Axelsson-Robertson, John E. Dick, Jonas Mattsson, Björn Önfelt, Mattias Carlsten, Michael Uhlin

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Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells by Tadayuki Akagi, Lee-Yung Shih, Seishi Ogawa, Joachim Gerss, Stephen R. Moore, Rhona Schreck, Norihiko Kawamata, Der-Cherng Liang, Masashi Sanada, Yasuhito Nannya, Stefan Deneberg, Vasilios Zachariadis, Ann Nordgren, Jee Hoon Song, Martin Dugas, Sören Lehmann, H. Phillip Koeffler

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Prediction model for drug response of acute myeloid leukemia patients by Quang Thinh Trac, Yudi Pawitan, Tian Mou, Tom Erkers, Päivi Östling, Anna Bohlin, Albin Österroos, Mattias Vesterlund, Rozbeh Jafari, Ioannis Siavelis, Helena Bäckvall, Santeri Kiviluoto, Lukas M. Orre, Mattias Rantalainen, Janne Lehtiö, Sören Lehmann, Olli Kallioniemi, Trung Nghia Vu

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Delineating functional and molecular impact of ex vivo sample handling in precision medicine by Nona Struyf, Albin Österroos, Mattias Vesterlund, Cornelia Arnroth, Tojo James, Stephanie Sunandar, Georgios Mermelekas, Anna Bohlin, Kerstin Hamberg Levedahl, Sofia Bengtzén, Rozbeh Jafari, Lukas M. Orre, Janne Lehtiö, Sören Lehmann, Päivi Östling, Olli Kallioniemi, Brinton Seashore-Ludlow, Tom Erkers

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P513: MOLECULAR PATTERN BY AGE AND OVERALL SURVIVAL IN ACUTE MYELOID LEUKEMIA: A POPULATION-BASED STUDY FROM THE SWEDISH AML REGISTRY. by Gunnar Juliusson, Christer Nilsson, Sören Lehmann, Martin Jädersten, Lovisa Wennström, Linda Fogelstrand, Panagiotis Baliakas, Tatjana Pandzic, Lucia Cavelier, Anna Eriksson, Albin Österroos, Anna Thunström, Benedicte Piauger, Bertil Uggla, Emma Ölander, Gustav Orrsjö, Jörg Cammenga, Kristina Myhr-Eriksson, Petter Willner Hjelm, Stefan Deneberg, Thoas Fioretos, Martin Höglund, Vladimir Lazarevic

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Biological and therapeutic implications of a unique subtype of NPM1 mutated AML by Arvind Singh Mer, Emily M. Heath, Seyed Ali Madani Tonekaboni, Nergiz Dogan-Artun, Sisira Kadambat Nair, Alex Murison, Laura Garcia-Prat, Liran Shlush, Rose Hurren, Veronique Voisin, Gary D. Bader, Corey Nislow, Mattias Rantalainen, Soren Lehmann, Mark Gower, Cynthia J. Guidos, Mathieu Lupien, John E. Dick, Mark D. Minden, Aaron D. Schimmer, Benjamin Haibe-Kains

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P506: CLINICAL VALIDATION OF THE NORDIC GUIDELINES FOR GERMLINE TESTING IN MYELOID NEOPLASMS: RESULTS FROM A MULTI-CENTER PROSPECTIVE COHORT STUDY by Bianca Tesi, Anna Eriksson, Berivan Baskin, Vladimir Lazarevic, Stefan Deneberg, Martin Höglund, Linda Fogelstrand, Johanna Ungerstedt, Tatjana Pandzic, Magnus Tobiasson, Hege Gravdahl Garelius, Ekaterina Kuchinskaya, Fredrik Persson, Helena Ågerstam, Bertil Uggla, Helene Hallböök, Thoas Fioretos, Ann-Charlotte Thuresson, Sören Lehmann, Claes Ladenvall, Gisela Barbany, Lovisa Vennström, Elisabeth Ejerblad, Lucia Cavelier, Jörg Cammenga, Martin Jädersten, Eva Hellström Lindberg, Panagiotis Baliakas

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Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy by Sean G Rudd, Nikolaos Tsesmetzis, Kumar Sanjiv, Cynthia BJ Paulin, Lakshmi Sandhow, Juliane Kutzner, Ida Hed Myrberg, Sarah S Bunten, Hanna Axelsson, Si Min Zhang, Azita Rasti, Petri Mäkelä, Si'Ana A Coggins, Sijia Tao, Sharda Suman, Rui M Branca, Georgios Mermelekas, Elisée Wiita, Sun Lee, Julian Walfridsson, Raymond F Schinazi, Baek Kim, Janne Lehtiö, Georgios Z Rassidakis, Katja Pokrovskaja Tamm, Ulrika Warpman‐Berglund, Mats Heyman, Dan Grandér, Sören Lehmann, Thomas Lundbäck, Hong Qian, Jan‐Inge Henter, Torsten Schaller, Thomas Helleday, Nikolas Herold

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Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance by Marta Anna Sobas, Amin T. Turki, Angela Villaverde Ramiro, Alberto Hernández Sánchez, Javier Martinez Elicegui, Teresa González, Raúl Azibeiro Melchor, María Abáigar, Laura Tur, Daniele Dall'Olio, Eric Sträng, Jesse M. Tettero, Gastone Castellani, Axel Benner, Konstanze Döhner, Christian Thiede, Klaus H. Metzeler, Torsten Haferlach, Frederik Damm, Rosa Ayala, Joaquín Martínez-López, Ken I Mills, Jorge Sierra, Sören Lehmann, Matteo G. Della Porta, Jiri Mayer, Dirk Reinhardt, Rubén Villoria Medina, Renate Schulze-Rath, Martje Barbus, Jesús María Hernández-Rivas, Brian J.P Huntly, Gert Ossenkoppele, Hartmut Döhner, Lars Bullinger

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