Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus by Søren R. Paludan, Jesper Melchjorsen, Sampsa Matikainen

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Induction of interferon-stimulated genes by Chlamydia pneumoniae in fibroblasts is mediated by intracellular nucleotide-sensing receptors. by Srikanth Chiliveru, Svend Birkelund, Søren R Paludan

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The STING inhibitor (ISD-017) reduces glomerulonephritis in 129.B6.Fcgr2b-deficient mice by Isara Alee, Papasara Chantawichitwong, Asada Leelahavanichkul, Søren R. Paludan, Trairak Pisitkun, Prapaporn Pisitkun

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TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults by Rasmus Offersen, Jesper Melchjorsen, Søren R. Paludan, Lars Østergaard, Martin Tolstrup, Ole S. Søgaard

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Early host defense against virus infections by Søren R. Paludan, Thomas Pradeu, Andreas Pichlmair, K. Brad Wray, Jacob Giehm Mikkelsen, David Olagnier, Trine H. Mogensen

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STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice. by Morten K Skouboe, Alice Knudsen, Line S Reinert, Cedric Boularan, Thierry Lioux, Eric Perouzel, Martin K Thomsen, Søren R Paludan

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STING Mediates Lupus via the Activation of Conventional Dendritic Cell Maturation and Plasmacytoid Dendritic Cell Differentiation by Arthid Thim-uam, Thaneas Prabakaran, Mookmanee Tansakul, Jiradej Makjaroen, Piriya Wongkongkathep, Naphat Chantaravisoot, Thammakorn Saethang, Asada Leelahavanichkul, Thitima Benjachat, Søren R. Paludan, Trairak Pisitkun, Prapaporn Pisitkun

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Interleukin-21 receptor signalling is important for innate immune protection against HSV-2 infections. by Sine K Kratholm, Marie B Iversen, Line Reinert, Simon K Jensen, Marianne Hokland, Thomas Andersen, Andrew Rankin, Deborah Young, Sebastian Frische, Søren R Paludan, Christian K Holm

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The alternative cap-binding complex is required for antiviral defense in vivo. by Anna Gebhardt, Valter Bergant, Daniel Schnepf, Markus Moser, Arno Meiler, Dieudonnée Togbe, Claire Mackowiak, Line S Reinert, Søren R Paludan, Bernhard Ryffel, Alexey Stukalov, Peter Staeheli, Andreas Pichlmair

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Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS by Line S. Reinert, Katarína Lopušná, Henriette Winther, Chenglong Sun, Martin K. Thomsen, Ramya Nandakumar, Trine H. Mogensen, Morten Meyer, Christian Vægter, Jens R. Nyengaard, Katherine A. Fitzgerald, Søren R. Paludan

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Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA. by Randi K Berg, Jesper Melchjorsen, Johanna Rintahaka, Elisabeth Diget, Stine Søby, Kristy A Horan, Robert J Gorelick, Sampsa Matikainen, Carsten S Larsen, Lars Ostergaard, Søren R Paludan, Trine H Mogensen

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An IKBKE variant conferring functional cGAS/STING pathway deficiency and susceptibility to recurrent HSV-2 meningitis by Azadeh Reyahi, Marie Studahl, Morten K. Skouboe, Stefanie Fruhwürth, Ryo Narita, Fanghui Ren, Moa Bjerhem Viklund, Marie B. Iversen, Mette Christiansen, Alexandra Svensson, Trine H. Mogensen, Kristina Eriksson, Søren R. Paludan

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The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice by Rafael Bayarri-Olmos, Laust Bruun Johnsen, Manja Idorn, Line S Reinert, Anne Rosbjerg, Søren Vang, Cecilie Bo Hansen, Charlotte Helgstrand, Jais Rose Bjelke, Theresa Bak-Thomsen, Søren R Paludan, Peter Garred, Mikkel-Ole Skjoedt

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T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication. by Randi K Berg, Stine H Rahbek, Emil Kofod-Olsen, Christian K Holm, Jesper Melchjorsen, David G Jensen, Anne Louise Hansen, Louise B Jørgensen, Lars Ostergaard, Martin Tolstrup, Carsten S Larsen, Søren R Paludan, Martin R Jakobsen, Trine H Mogensen

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The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation by Ensieh Farahani, Line S. Reinert, Ryo Narita, Manutea C. Serrero, Morten Kelder Skouboe, Demi van der Horst, Sonia Assil, Baocun Zhang, Marie B. Iversen, Eugenio Gutierrez, Hossein Hazrati, Mogens Johannsen, David Olagnier, Reiner Kunze, Mark Denham, Trine H. Mogensen, Michael Lappe, Søren R. Paludan

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A Capsid Virus-Like Particle-Based SARS-CoV-2 Vaccine Induces High Levels of Antibodies and Protects Rhesus Macaques by Ariane Volkmann, Gerrit Koopman, Petra Mooij, Ernst J. Verschoor, Babs E. Verstrepen, Willy M. J. M. Bogers, Manja Idorn, Søren R. Paludan, Søren Vang, Morten A. Nielsen, Morten A. Nielsen, Adam F. Sander, Adam F. Sander, Adam F. Sander, Carolin Schmittwolf, Hubertus Hochrein, Paul Chaplin

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Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds by Bao-cun Zhang, Marlene F. Laursen, Lili Hu, Hossein Hazrati, Ryo Narita, Lea S. Jensen, Aida S. Hansen, Jinrong Huang, Yan Zhang, Xiangning Ding, Maimaitili Muyesier, Emil Nilsson, Agnieszka Banasik, Christina Zeiler, Trine H. Mogensen, Anders Etzerodt, Ralf Agger, Mogens Johannsen, Emil Kofod-Olsen, Søren R. Paludan, Martin R. Jakobsen

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A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology by Thaneas Prabakaran, Anne Troldborg, Sarinya Kumpunya, Isara Alee, Emilija Marinković, Samuel J. Windross, Ramya Nandakumar, Ryo Narita, Bao-cun Zhang, Mikkel Carstensen, Pichpisith Vejvisithsakul, Mikkel H.S. Marqvorsen, Marie B. Iversen, Christian K. Holm, Lars J. Østergaard, Finn Skou Pedersen, Trairak Pisitkun, Rayk Behrendt, Prapaporn Pisitkun, Søren R. Paludan

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Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses by Christian K. Holm, Stine H. Rahbek, Hans Henrik Gad, Rasmus O. Bak, Martin R. Jakobsen, Zhaozaho Jiang, Anne Louise Hansen, Simon K. Jensen, Chenglong Sun, Martin K. Thomsen, Anders Laustsen, Camilla G. Nielsen, Kasper Severinsen, Yingluo Xiong, Dara L. Burdette, Veit Hornung, Robert Jan Lebbink, Mogens Duch, Katherine A. Fitzgerald, Shervin Bahrami, Jakob Giehm Mikkelsen, Rune Hartmann, Søren R. Paludan

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SAM68 directs STING signaling to apoptosis in macrophages by Demi van der Horst, Naziia Kurmasheva, Mikkel H. S. Marqvorsen, Sonia Assil, Anna H. F. Rahimic, Christoph F. Kollmann, Leandro Silva da Costa, Qi Wu, Jian Zhao, Eleonora Cesari, Marie B. Iversen, Fanghui Ren, Trine I. Jensen, Ryo Narita, Vivien R. Schack, Bao-cun Zhang, Rasmus O. Bak, Claudio Sette, Robert A. Fenton, Jacob G. Mikkelsen, Søren R. Paludan, David Olagnier

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